Display options
Cite
Rajasekaran S, Rajaguru P, Sudhakar Gandhi PS. MicroRNAs as potential targets for progressive pulmonary fibrosis. Front Pharmacol. 2015;6:254doi: 10.3389/fphar.2015.00254.
Rajasekaran, S., Rajaguru, P., & Sudhakar Gandhi, P. S. (2015). MicroRNAs as potential targets for progressive pulmonary fibrosis. Frontiers in pharmacology, 6254. https://doi.org/10.3389/fphar.2015.00254
Rajasekaran, Subbiah, et al. "MicroRNAs as potential targets for progressive pulmonary fibrosis." Frontiers in pharmacology vol. 6 (2015): 254. doi: https://doi.org/10.3389/fphar.2015.00254
Rajasekaran S, Rajaguru P, Sudhakar Gandhi PS. MicroRNAs as potential targets for progressive pulmonary fibrosis. Front Pharmacol. 2015 Nov 05;6:254. doi: 10.3389/fphar.2015.00254. eCollection 2015. PMID: 26594173; PMCID: PMC4633493.
Copy Download .nbib Format: NLM
Share it on

Front Pharmacol. 2015 Nov 05;6:254. doi: 10.3389/fphar.2015.00254. eCollection 2015.

MicroRNAs as potential targets for progressive pulmonary fibrosis.

Frontiers in pharmacology

Subbiah Rajasekaran, P Rajaguru, P S Sudhakar Gandhi

Affiliations

  1. Department of Biotechnology, Bharathidasan Institute of Technology Campus, Anna University Tiruchirappalli, India.

PMID: 26594173 PMCID: PMC4633493 DOI: 10.3389/fphar.2015.00254

Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and devastating disorder. It is characterized by alveolar epithelial cell injury and activation, infiltration of inflammatory cells, initiation of epithelial mesenchymal transition (EMT), aberrant proliferation and activation of fibroblasts, exaggerated deposition of extracellular matrix (ECM) proteins, and finally leading to the destruction of lung parenchyma. MicroRNAs (miRNAs) are endogenous small non-coding RNA molecules that post-transcriptionally regulate gene expression in diverse biological and pathological processes, including cell proliferation, differentiation, apoptosis and metastasis. As a result, miRNAs have emerged as a major area of biomedical research with relevance to pulmonary fibrosis. In this context, the present review discusses specific patterns of dysregulated miRNAs in patients with IPF. Further, we discuss the current understanding of miRNAs involvement in regulating lung inflammation, TGF-β1-mediated EMT and fibroblast differentiation processes, ECM genes expression, and in the progression of lung fibrosis. The possible future directions that might lead to novel therapeutic strategies for the treatment of pulmonary fibrosis are also reviewed.

Keywords: TGF-β1; epithelial cells; fibroblasts; idiopathic pulmonary fibrosis; inflammation; miRNAs; type-1-collagen; α-SMA

References

  1. Circ Res. 2012 Feb 3;110(3):508-22 - PubMed
  2. Gene. 2015 May 10;562(1):138-44 - PubMed
  3. Am J Respir Crit Care Med. 2002 Aug 15;166(4):510-3 - PubMed
  4. Am J Respir Crit Care Med. 2006 Oct 1;174(7):810-6 - PubMed
  5. Nat Rev Mol Cell Biol. 2010 Apr;11(4):252-63 - PubMed
  6. Br J Pharmacol. 2008 Mar;153 Suppl 1:S241-6 - PubMed
  7. Front Physiol. 2012 Mar 19;3:49 - PubMed
  8. Biochim Biophys Acta. 2013 Jul;1832(7):911-21 - PubMed
  9. Development. 1994 Sep;120(9):2421-30 - PubMed
  10. Lab Invest. 1989 May;60(5):643-50 - PubMed
  11. PLoS Biol. 2007 Aug;5(8):e203 - PubMed
  12. Respir Res. 2013 Sep 24;14:95 - PubMed
  13. Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L152-60 - PubMed
  14. N Engl J Med. 2001 Aug 16;345(7):517-25 - PubMed
  15. Int J Biochem Cell Biol. 2004 Apr;36(4):598-606 - PubMed
  16. Am J Med Sci. 2011 Jun;341(6):444-9 - PubMed
  17. Lancet. 1996 Feb 3;347(8997):284-9 - PubMed
  18. J Immunol. 2001 Aug 15;167(4):1977-81 - PubMed
  19. Proc Am Thorac Soc. 2006 Jun;3(4):350-6 - PubMed
  20. Life Sci. 2014 Sep 26;114(1):20-8 - PubMed
  21. Semin Respir Crit Care Med. 2006 Dec;27(6):600-12 - PubMed
  22. Am J Respir Crit Care Med. 2010 Apr 15;181(8):771-2 - PubMed
  23. Ann Intern Med. 2001 Jan 16;134(2):136-51 - PubMed
  24. Mol Ther. 2012 Jun;20(6):1251-60 - PubMed
  25. Mutat Res. 2012 Feb 1;730(1-2):52-8 - PubMed
  26. Am J Hum Genet. 2006 Jul;79(1):149-54 - PubMed
  27. Thorax. 1967 Jul;22(4):291-304 - PubMed
  28. J Clin Invest. 2007 Mar;117(3):524-9 - PubMed
  29. Am J Respir Crit Care Med. 2010 Jul 15;182(2):220-9 - PubMed
  30. Am J Pathol. 2012 Feb;180(2):484-93 - PubMed
  31. J Biol Chem. 2008 Jun 6;283(23):15878-83 - PubMed
  32. PLoS One. 2008 May 14;3(5):e2142 - PubMed
  33. Birth Defects Res C Embryo Today. 2006 Mar;78(1):1-10 - PubMed
  34. Proc Natl Acad Sci U S A. 2009 May 12;106(19):7915-20 - PubMed
  35. PLoS Genet. 2013;9(2):e1003291 - PubMed
  36. Cell Death Dis. 2014 May 22;5:e1238 - PubMed
  37. Eur Respir J. 2001 Jun;17(6):1220-7 - PubMed
  38. Biogerontology. 2013 Dec;14(6):609-15 - PubMed
  39. J Exp Med. 2011 Jul 4;208(7):1339-50 - PubMed
  40. Genes Dev. 2008 Apr 1;22(7):894-907 - PubMed
  41. Am J Respir Cell Mol Biol. 2001 Jan;24(1):1-11 - PubMed
  42. Nature. 2000 Feb 24;403(6772):901-6 - PubMed
  43. N Engl J Med. 2005 Oct 27;353(17):1793-801 - PubMed
  44. Fibrogenesis Tissue Repair. 2012 Jul 23;5(1):11 - PubMed
  45. Lancet. 2009 May 30;373(9678):1905-17 - PubMed
  46. Bioessays. 2005 Sep;27(9):894-903 - PubMed
  47. Clin J Am Soc Nephrol. 2009 Jul;4(7):1255-66 - PubMed
  48. J Dermatol Sci. 2005 Jul;39(1):1-7 - PubMed
  49. Respir Med. 2009 Aug;103(8):1122-9 - PubMed
  50. Clin Respir J. 2016 Jan;10 (1):104-11 - PubMed
  51. Am Rev Respir Dis. 1991 Sep;144(3 Pt 1):706-13 - PubMed
  52. Am J Respir Crit Care Med. 2013 Feb 15;187(4):397-405 - PubMed
  53. J Lipid Res. 2013 May;54(5):1174-81 - PubMed
  54. Am J Physiol. 1998 Dec;275(6 Pt 1):L1192-9 - PubMed
  55. Eur Respir J. 2005 Apr;25(4):701-7 - PubMed
  56. Am J Physiol. 1999 Dec;277(6 Pt 1):L1158-64 - PubMed
  57. Cold Spring Harb Perspect Biol. 2011 Dec 01;3(12):null - PubMed
  58. Am J Physiol Lung Cell Mol Physiol. 2014 Mar 15;306(6):L534-42 - PubMed
  59. Am J Respir Crit Care Med. 2002 Jul 15;166(2):236-46 - PubMed
  60. Mucosal Immunol. 2009 Mar;2(2):103-21 - PubMed
  61. J Cell Biochem. 2014 Sep;115(9):1539-48 - PubMed
  62. EMBO Mol Med. 2014 Sep 19;6(10):1347-56 - PubMed
  63. Lab Invest. 1989 Apr;60(4):473-85 - PubMed
  64. Am J Pathol. 2011 Sep;179(3):1074-80 - PubMed
  65. Biomarkers. 2012 Aug;17(5):435-40 - PubMed
  66. Curr Opin Cell Biol. 2004 Jun;16(3):223-9 - PubMed
  67. Curr Opin Rheumatol. 2008 Nov;20(6):707-12 - PubMed
  68. Protein Cell. 2012 Oct;3(10):726-38 - PubMed
  69. Open Rheumatol J. 2012;6:72-9 - PubMed
  70. J Am Soc Nephrol. 2004 Jan;15(1):1-12 - PubMed
  71. Am J Respir Crit Care Med. 1997 Jan;155(1):242-8 - PubMed
  72. Am J Respir Crit Care Med. 2013 Oct 1;188(7):820-30 - PubMed
  73. Int J Biochem Cell Biol. 2014 Aug;53:432-41 - PubMed
  74. Am J Respir Crit Care Med. 2011 Mar 15;183(6):788-824 - PubMed
  75. J Cell Biochem. 2013 Jun;114(6):1336-42 - PubMed
  76. Am J Physiol Lung Cell Mol Physiol. 2014 Aug 15;307(4):L283-94 - PubMed
  77. Am J Respir Cell Mol Biol. 2014 May;50(5):882-92 - PubMed
  78. Am J Physiol Lung Cell Mol Physiol. 2014 Oct 15;307(8):L632-42 - PubMed
  79. EMBO J. 2008 Dec 17;27(24):3300-10 - PubMed
  80. Curr Stem Cell Res Ther. 2007 Dec;2(4):264-71 - PubMed
  81. Nature. 2008 Dec 18;456(7224):980-4 - PubMed
  82. Transl Res. 2011 Apr;157(4):191-9 - PubMed
  83. Clin Respir J. 2014 Jan;8(1):55-62 - PubMed
  84. Oncol Lett. 2011 Nov;2(6):1019-1023 - PubMed
  85. Science. 2007 Dec 21;318(5858):1931-4 - PubMed
  86. Genes Dev. 2004 Dec 15;18(24):3016-27 - PubMed
  87. Nat Cell Biol. 2008 May;10 (5):593-601 - PubMed
  88. Cell Signal. 2013 Jan;25(1):264-8 - PubMed
  89. Cell Cycle. 2008 Oct;7(20):3143-8 - PubMed
  90. Cell Tissue Res. 2010 Jan;339(1):221-35 - PubMed
  91. J Biol Chem. 2009 Apr 24;284(17):11326-35 - PubMed
  92. Mod Pathol. 1998 Nov;11(11):1064-70 - PubMed
  93. J Exp Med. 2010 Aug 2;207(8):1589-97 - PubMed
  94. Cancer Biol Ther. 2010 Dec 15;10(12):1224-32 - PubMed
  95. Am J Physiol. 1995 Dec;269(6 Pt 1):L819-28 - PubMed
  96. Biochem Biophys Res Commun. 1996 Aug 5;225(1):161-6 - PubMed
  97. Am J Respir Cell Mol Biol. 2012 Dec;47(6):879-87 - PubMed
  98. Thorax. 2001 Dec;56(12):907-15 - PubMed
  99. Nucleic Acids Res. 2013 Apr 1;41(6):3833-44 - PubMed
  100. Cell Res. 2007 Aug;17(8):661-3 - PubMed
  101. J Clin Invest. 1995 Jul;96(1):250-9 - PubMed
  102. J Asthma. 2013 Nov;50(9):960-4 - PubMed
  103. Arch Pathol Lab Med. 2011 Jun;135(6):780-8 - PubMed
  104. Am J Respir Cell Mol Biol. 2011 Aug;45(2):287-94 - PubMed
  105. Cell. 2009 Jan 23;136(2):215-33 - PubMed
  106. Clin Epidemiol. 2013 Nov 25;5:483-92 - PubMed
  107. Chest. 2005 Jan;127(1):266-74 - PubMed
  108. Am J Pathol. 1991 May;138(5):1257-65 - PubMed
  109. Hepatology. 2011 Jan;53(1):209-18 - PubMed
  110. FASEB J. 2013 Jun;27(6):2382-91 - PubMed
  111. Nature. 2005 Aug 4;436(7051):740-4 - PubMed
  112. Nature. 2004 Nov 11;432(7014):231-5 - PubMed
  113. J Pathol. 2008 Jan;214(2):199-210 - PubMed
  114. N Engl J Med. 2011 Apr 21;364(16):1503-12 - PubMed
  115. Cell. 2008 Mar 7;132(5):875-86 - PubMed
  116. Thorax. 1996 Jul;51(7):717-20 - PubMed
  117. Arch Biochem Biophys. 2015 Jan 15;566:49-57 - PubMed
  118. Biochem Biophys Res Commun. 2010 Apr 9;394(3):623-7 - PubMed
  119. Annu Rev Pathol. 2009;4:199-227 - PubMed
  120. Ann Intern Med. 1976 Dec;85(6):769-88 - PubMed
  121. Biochem Biophys Res Commun. 2014 Nov 28;454(4):512-7 - PubMed
  122. J Leukoc Biol. 2008 Feb;83(2):237-44 - PubMed
  123. J Clin Invest. 2011 Apr;121(4):1373-85 - PubMed
  124. Multidiscip Respir Med. 2013 Aug 09;8(1):53 - PubMed
  125. Mol Ther. 2014 Jun;22(6):1122-33 - PubMed

Publication Types