Iran J Reprod Med. 2015 Sep;13(9):577-82.
Evaluation of CD56(dim) and CD56(bright) natural killer cells in peripheral blood of women with IVF failures.
Iranian journal of reproductive medicine
Farahnaz Mardanian, Moones Kazeroonizadeh, Bahman Rashidi
Affiliations
Affiliations
- Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
- Department of Anatomy, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
PMID: 26568763
PMCID: PMC4637126
Abstract
BACKGROUND: Infertility is an increasing medical and social problem. In vitro fertilization (IVF) has become a common and accessible treatment for a wide variety of indications that have variable outcomes. Natural killer (NK) cells have been identified as relevant immunological factors involved in reproductive success or failure.
OBJECTIVE: The aim of this study was to compare the percentage of peripheral blood CD56(+) (CD56(dim) and CD56(bright)) cells and the level of NK cell in patients with IVF failure with those of successful IVF control women.
MATERIALS AND METHODS: We assessed the level of CD56(dim) CD16(+) and CD56(bright) CD16(-) cells in 50 women under IVF treatment and compared between successful IVF and IVF failure with the flowcytometry technique.
RESULTS: Of studied women, 68% did not response to IVF therapy and 32% had successful IVF, the level of CD56(dim) CD16(+) cells in women with IVF failure was significantly higher than successful IVF (p<0.0001) but the level of CD56(bright) CD16(-) cells was not significantly different between women with IVF failure and successful IVF (p=0.28).
CONCLUSION: The results of present study demonstrated that the level of NK cells as a risk factor is associated with pregnancy loss in women with IVF failure. However, number of sample in this study is low and further studies with more sample size are needed to be done. We suggest considering treatment option for women undergoing repeated IVF failure with increased percentage of CD56(dim) cells and the level of peripheral blood NK cell.
Keywords: In vitro fertilization; Infertility; Natural killer cells
References
- Respirology. 2012 Jan;17(1):155-63 - PubMed
- N Engl J Med. 2001 Nov 8;345(19):1400-8 - PubMed
- Am J Reprod Immunol. 2012 May;67(5):434-42 - PubMed
- Am J Reprod Immunol. 2003 Oct;50(4):351-4 - PubMed
- Am J Reprod Immunol. 1996 Apr;35(4):352-9 - PubMed
- Reprod Biol Endocrinol. 2014 Jan 29;12:9 - PubMed
- J Assist Reprod Genet. 2006 Jan;23(1):1-13 - PubMed
- J Reprod Immunol. 2010 Dec;87(1-2):60-6 - PubMed
- Am J Reprod Immunol. 2001 Aug;46(2):132-6 - PubMed
- Am J Reprod Immunol. 2002 Nov;48(5):323-8 - PubMed
- Am J Reprod Immunol. 2008 Mar;59(3):259-65 - PubMed
- Lancet. 1995 May 27;345(8961):1340-2 - PubMed
- J Reprod Immunol. 2007 Dec;76(1-2):23-9 - PubMed
- Am J Reprod Immunol. 1999 Jun;41(6):413-22 - PubMed
- Am J Reprod Immunol. 2012 Sep;68(3):218-25 - PubMed
- Am J Reprod Immunol. 2007 Nov;58(5):447-59 - PubMed
- Am J Reprod Immunol. 2012 Jul;68(1):75-84 - PubMed
- Folia Histochem Cytobiol. 2007;45 Suppl 1:S73-7 - PubMed
- Lancet. 2000 Jun 3;355(9219):1928-9 - PubMed
- Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):728-32 - PubMed
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