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Zhang YB, Guo ZD, Li MY, et al. Cerebrospinal fluid from rats given hypoxic preconditioning protects neurons from oxygen-glucose deprivation-induced injury. Neural Regen Res. 2015;10(9):1471-6doi: 10.4103/1673-5374.165519.
Zhang, Y. B., Guo, Z. D., Li, M. Y., Li, S. J., Niu, J. Z., Yang, M. F., Ji, X. M., & Lv, G. W. (2015). Cerebrospinal fluid from rats given hypoxic preconditioning protects neurons from oxygen-glucose deprivation-induced injury. Neural regeneration research, 10(9), 1471-6. https://doi.org/10.4103/1673-5374.165519
Zhang, Yan-Bo, et al. "Cerebrospinal fluid from rats given hypoxic preconditioning protects neurons from oxygen-glucose deprivation-induced injury." Neural regeneration research vol. 10,9 (2015): 1471-6. doi: https://doi.org/10.4103/1673-5374.165519
Zhang YB, Guo ZD, Li MY, Li SJ, Niu JZ, Yang MF, Ji XM, Lv GW. Cerebrospinal fluid from rats given hypoxic preconditioning protects neurons from oxygen-glucose deprivation-induced injury. Neural Regen Res. 2015 Sep;10(9):1471-6. doi: 10.4103/1673-5374.165519. PMID: 26604909; PMCID: PMC4625514.
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Neural Regen Res. 2015 Sep;10(9):1471-6. doi: 10.4103/1673-5374.165519.

Cerebrospinal fluid from rats given hypoxic preconditioning protects neurons from oxygen-glucose deprivation-induced injury.

Neural regeneration research

Yan-Bo Zhang, Zheng-Dong Guo, Mei-Yi Li, Si-Jie Li, Jing-Zhong Niu, Ming-Feng Yang, Xun-Ming Ji, Guo-Wei Lv

Affiliations

  1. Department of Neurology, Affiliated Hospital of Taishan Medical University, Taian, Shandong Province, China.
  2. Department of Endocrinology, Affiliated Hospital of Taishan Medical University, Taian, Shandong Province, China.
  3. Department of Neurology, Shandong Taishan Chronic Disease Hospital, Taian, Shandong Province, China.
  4. Hypoxia Medical Institute, Xuanwu Hospital, Capital Medical University, Beijing, China.

PMID: 26604909 PMCID: PMC4625514 DOI: 10.4103/1673-5374.165519

Abstract

Hypoxic preconditioning activates endogenous mechanisms that protect against cerebral ischemic and hypoxic injury. To better understand these protective mechanisms, adult rats were housed in a hypoxic environment (8% O2/92% N2) for 3 hours, and then in a normal oxygen environment for 12 hours. Their cerebrospinal fluid was obtained to culture cortical neurons from newborn rats for 1 day, and then the neurons were exposed to oxygen-glucose deprivation for 1.5 hours. The cerebrospinal fluid from rats subjected to hypoxic preconditioning reduced oxygen-glucose deprivation-induced injury, increased survival rate, upregulated Bcl-2 expression and downregulated Bax expression in the cultured cortical neurons, compared with control. These results indicate that cerebrospinal fluid from rats given hypoxic preconditioning protects against oxygen-glucose deprivation-induced injury by affecting apoptosis-related protein expression in neurons from newborn rats.

Keywords: Bcl-2/Bax; apoptosis; cerebral cortex; cerebrospinal fluid; hypoxic preconditioning; nerve regeneration; neural regeneration; neurons; oxygen-glucose deprivation

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