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Leone JP, Leone BA. Breast cancer brain metastases: the last frontier. Exp Hematol Oncol. 2015;4:33doi: 10.1186/s40164-015-0028-8.
Leone, J. P., & Leone, B. A. (2015). Breast cancer brain metastases: the last frontier. Experimental hematology & oncology, 433. https://doi.org/10.1186/s40164-015-0028-8
Leone, José Pablo, and Leone, Bernardo Amadeo. "Breast cancer brain metastases: the last frontier." Experimental hematology & oncology vol. 4 (2015): 33. doi: https://doi.org/10.1186/s40164-015-0028-8
Leone JP, Leone BA. Breast cancer brain metastases: the last frontier. Exp Hematol Oncol. 2015 Nov 24;4:33. doi: 10.1186/s40164-015-0028-8. eCollection 2015. PMID: 26605131; PMCID: PMC4657380.
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Exp Hematol Oncol. 2015 Nov 24;4:33. doi: 10.1186/s40164-015-0028-8. eCollection 2015.

Breast cancer brain metastases: the last frontier.

Experimental hematology & oncology

José Pablo Leone, Bernardo Amadeo Leone

Affiliations

  1. University of Iowa Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, C32 GH, 200 Hawkins Drive, Iowa City, IA 52242 USA.
  2. Grupo Oncológico Cooperativo del Sur (GOCS), Rivadavia 360, 8300 Neuquén, Argentina.

PMID: 26605131 PMCID: PMC4657380 DOI: 10.1186/s40164-015-0028-8

Abstract

Breast cancer is a common cause of brain metastases, with metastases occurring in at least 10-16 % of patients. Longer survival of patients with metastatic breast cancer and the use of better imaging techniques are associated with an increased incidence of brain metastases. Unfortunately, patients who develop brain metastases tend to have poor prognosis with short overall survival. In addition, brain metastases are a major cause of morbidity, associated with progressive neurologic deficits that result in a reduced quality of life. Tumor subtypes play a key role in prognosis and treatment selection. Current therapies include surgery, whole-brain radiation therapy, stereotactic radiosurgery, chemotherapy and targeted therapies. However, the timing and appropriate use of these therapies is controversial and careful patient selection by using available prognostic tools is extremely important. This review will focus on current treatment options, novel therapies, future approaches and ongoing clinical trials for patients with breast cancer brain metastases.

Keywords: Brain metastasis; Breast cancer; Metastatic breast cancer

References

  1. J Neurosurg. 2010 Dec;113 Suppl:73-8 - PubMed
  2. Ann Oncol. 2006 Jun;17(6):935-44 - PubMed
  3. Ann Oncol. 2006 Jun;17 (6):952-6 - PubMed
  4. N Engl J Med. 2012 Nov 8;367(19):1783-91 - PubMed
  5. Lancet Oncol. 2014 Apr;15(4):387-95 - PubMed
  6. Int J Radiat Oncol Biol Phys. 2007 Aug 1;68(5):1388-95 - PubMed
  7. Br J Cancer. 2012 Sep 25;107(7):1075-82 - PubMed
  8. Clin Cancer Res. 2009 Feb 15;15(4):1452-9 - PubMed
  9. Cancer. 2006 Aug 15;107(4):696-704 - PubMed
  10. J Neurooncol. 2008 Jul;88(3):359-65 - PubMed
  11. JAMA. 2006 Jun 7;295(21):2483-91 - PubMed
  12. Lancet Oncol. 2009 Nov;10(11):1037-44 - PubMed
  13. Lancet Neurol. 2005 May;4(5):289-98 - PubMed
  14. J Clin Oncol. 2000 Jun;18(11):2349-51 - PubMed
  15. Br J Cancer. 2009 Mar 24;100(6):894-900 - PubMed
  16. BMC Cancer. 2012 Jul 28;12:322 - PubMed
  17. J Neurooncol. 1995;24(3):299-301 - PubMed
  18. Int J Radiat Oncol Biol Phys. 2008 Feb 1;70(2):510-4 - PubMed
  19. Cancer. 1986 Aug 15;58(4):832-9 - PubMed
  20. Breast Cancer Res Treat. 2008 Dec;112(3):533-43 - PubMed
  21. Cancer Med. 2014 Jun;3(3):565-71 - PubMed
  22. Ann Oncol. 2011 Mar;22(3):625-30 - PubMed
  23. J Neurooncol. 2010 Jan;96(1):45-68 - PubMed
  24. Cancer. 2012 May 1;118(9):2486-93 - PubMed
  25. Lancet. 2004 May 22;363(9422):1665-72 - PubMed
  26. Breast Cancer Res Treat. 2014 Aug;147(1):103-12 - PubMed
  27. Anticancer Res. 2006 May-Jun;26(3B):2259-63 - PubMed
  28. J Clin Oncol. 2008 Apr 20;26(12):1993-9 - PubMed
  29. Breast Cancer Res. 2011;13(6):R125 - PubMed
  30. Ann Oncol. 2010 May;21(5):942-8 - PubMed
  31. J Neurooncol. 2013 May;112(3):467-72 - PubMed
  32. Int J Radiat Oncol Biol Phys. 2002 Jul 1;53(3):519-26 - PubMed
  33. Clin Transl Oncol. 2014 May;16(5):436-46 - PubMed
  34. Am J Clin Oncol. 1990 Oct;13(5):427-32 - PubMed
  35. J Clin Oncol. 2015 Jul 10;33(20):2239-45 - PubMed
  36. J Clin Oncol. 2006 Dec 20;24(36):5658-63 - PubMed
  37. BMC Cancer. 2009 Apr 07;9:105 - PubMed
  38. J Neurosurg. 2008 Dec;109 Suppl:87-9 - PubMed
  39. Breast Cancer Res. 2008;10(1):R20 - PubMed
  40. Clin Cancer Res. 2011 Jul 15;17(14):4834-43 - PubMed
  41. Breast Cancer Res Treat. 1988 Sep;12(1):83-6 - PubMed
  42. Cancer. 2008 Nov 15;113(10):2638-45 - PubMed
  43. J Nucl Med. 2013 Nov;54(11):1869-75 - PubMed
  44. Int J Radiat Oncol Biol Phys. 2012 Apr 1;82(5):2111-7 - PubMed
  45. Br J Cancer. 2010 Mar 16;102(6):995-1002 - PubMed
  46. Eur J Cancer. 1999 Apr;35(4):580-5 - PubMed
  47. Clin Pharmacol Ther. 2010 May;87(5):586-92 - PubMed
  48. Oncology. 2012;83(3):141-50 - PubMed
  49. Breast Cancer Res Treat. 2008 Oct;111(3):523-30 - PubMed
  50. J Neurosurg. 2013 Jun;118(6):1258-68 - PubMed
  51. Breast. 2014 Oct;23(5):623-8 - PubMed
  52. J Clin Oncol. 2011 Jan 10;29(2):134-41 - PubMed
  53. Breast J. 2009 Jul-Aug;15(4):435-7 - PubMed
  54. Acta Neurochir (Wien). 2008 Jun;150(6):613-4; discussion 614-5 - PubMed
  55. J Neurooncol. 1991 Apr;10(2):173-7 - PubMed
  56. Eur J Surg Oncol. 2011 Jul;37(7):635-42 - PubMed
  57. J Clin Oncol. 2015 May 10;33(14):1564-73 - PubMed
  58. Ann Oncol. 2008 Jul;19(7):1242-8 - PubMed
  59. Cancer. 2011 Apr 15;117(8):1602-11 - PubMed
  60. PLoS One. 2014 Feb 24;9(2):e89389 - PubMed
  61. J Neurooncol. 2009 Oct;95(1):95-9 - PubMed
  62. Am J Pathol. 2005 Oct;167(4):913-20 - PubMed
  63. Nat Rev Cancer. 2009 Apr;9(4):274-84 - PubMed
  64. Breast. 2006 Jun;15(3):440-2 - PubMed
  65. Neurologist. 2004 Jan;10 (1):31-46 - PubMed
  66. Cancer. 1999 Apr 1;85(7):1599-605 - PubMed
  67. Ann Oncol. 2015 Jan;26(1):113-9 - PubMed
  68. Expert Opin Pharmacother. 2010 May;11(7):1089-100 - PubMed
  69. Int J Clin Oncol. 2013 Aug;18(4):621-8 - PubMed
  70. Am J Clin Oncol. 1996 Oct;19(5):509-11 - PubMed
  71. J Neurooncol. 2007 Nov;85(2):223-7 - PubMed
  72. J Neurooncol. 2008 Jan;86(2):231-8 - PubMed
  73. JAMA. 1998 Nov 4;280(17):1485-9 - PubMed
  74. J Neurooncol. 2007 Dec;85(3):311-7 - PubMed
  75. Ann Oncol. 2014 Jun;25(6):1116-21 - PubMed
  76. J Clin Oncol. 2004 Sep 1;22(17):3608-17 - PubMed
  77. Int J Radiat Oncol Biol Phys. 1999 Sep 1;45(2):427-34 - PubMed
  78. Cancer. 1992 Feb 15;69(4):972-80 - PubMed
  79. Cancer. 1996 Oct 1;78(7):1470-6 - PubMed
  80. J Clin Oncol. 2007 Apr 1;25(10):1260-6 - PubMed
  81. J Neurooncol. 2005 Jan;71(1):61-5 - PubMed
  82. Ann Neurol. 1993 Jun;33(6):583-90 - PubMed
  83. Lancet Oncol. 2013 Jan;14(1):64-71 - PubMed
  84. Oncotarget. 2015 Oct 6;6(30):30327-33 - PubMed
  85. J Clin Oncol. 2014 Jul 1;32(19):2078-99 - PubMed
  86. J Clin Oncol. 2014 Jul 1;32(19):2100-8 - PubMed
  87. Br J Cancer. 1991 Apr;63(4):641-5 - PubMed
  88. J Clin Oncol. 2013 Jan 1;31(1):65-72 - PubMed
  89. Oncologist. 2008 Jul;13(7):739-50 - PubMed
  90. N Engl J Med. 1990 Feb 22;322(8):494-500 - PubMed
  91. Cancer Med. 2015 Jul;4(7):989-94 - PubMed
  92. Cancer. 2006 Sep 15;107(6):1348-54 - PubMed
  93. N Engl J Med. 2015 Feb 19;372(8):724-34 - PubMed
  94. Int J Radiat Oncol Biol Phys. 2008 Apr 1;70(5):1319-24 - PubMed

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