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Nerli R, Jali M, Guntaka AK, et al. Type 2 diabetes mellitus and renal stones. Adv Biomed Res. 2015;4:180doi: 10.4103/2277-9175.164012.
Nerli, R., Jali, M., Guntaka, A. K., Patne, P., Patil, S., & Hiremath, M. B. (2015). Type 2 diabetes mellitus and renal stones. Advanced biomedical research, 4180. https://doi.org/10.4103/2277-9175.164012
Nerli, Rajendra, et al. "Type 2 diabetes mellitus and renal stones." Advanced biomedical research vol. 4 (2015): 180. doi: https://doi.org/10.4103/2277-9175.164012
Nerli R, Jali M, Guntaka AK, Patne P, Patil S, Hiremath MB. Type 2 diabetes mellitus and renal stones. Adv Biomed Res. 2015 Aug 31;4:180. doi: 10.4103/2277-9175.164012. eCollection 2015. PMID: 26605219; PMCID: PMC4617153.
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Adv Biomed Res. 2015 Aug 31;4:180. doi: 10.4103/2277-9175.164012. eCollection 2015.

Type 2 diabetes mellitus and renal stones.

Advanced biomedical research

Rajendra Nerli, Mallikarjuna Jali, Ajay Kumar Guntaka, Pravin Patne, Shivagouda Patil, Murigendra Basayya Hiremath

Affiliations

  1. Department of Urology, KLES Kidney Foundation, Karnatak University, Karnataka, India.
  2. KLES Diabetes Centre, Jawaharlal Nehru Medical College, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, KLE University, Karnataka, India.
  3. Department of Biotechnology and Microbiology, Karnatak University, Karnataka, India.

PMID: 26605219 PMCID: PMC4617153 DOI: 10.4103/2277-9175.164012

Abstract

BACKGROUND: The incidence of urinary stone disease has shown a steep rise in recent decades along with marked modifications in dietary habits and life- style. There has been an increased prevalence of urinary stone disease in patients with diabetes. We took up this study to determine the association of diabetes mellitus with kidney stones in patients undergoing surgical treatment.

MATERIALS AND METHODS: Patients presenting with renal stones for surgical management formed the study group. Body mass index (BMI) was calculated by noting the weight and height of the patient. The extracted stone/stone fragments were analyzed to determine the chemical composition. Urinary pH was similarly noted in all.

RESULTS: The mean BMI among the diabetics was 26.35 ± 5.20 (range 17.75-35.60), whereas the mean BMI among the non-diabetics was 23.41 ± 2.85 (range 17.71-31.62) (P < 0.0004). The incidence of uric acid calculi in the diabetics was significantly high (P < 0.03). The mean urinary pH among the diabetics was 5.61 ± 0.36 and among the non-diabetics was 6.87 ± 0.32, which was significantly lower (P < 0.000044).

CONCLUSIONS: There is a strong association between type 2 diabetes and uric acid stone formation. There is also a strong association between diabetes mellitus, BMI, and also with lower urinary pH.

Keywords: Diabetes mellitus; renal stones; uric acid stones; urolithiasis

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