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Yoshioka Y, Katsuda T, Ochiya T. Circulating microRNAs as Hormones: Intercellular and Inter-organ Conveyors of Epigenetic Information?. Exp Suppl. 2015;106:255-267doi: 10.1007/978-3-0348-0955-9_12.
Yoshioka, Y., Katsuda, T., & Ochiya, T. (2015). Circulating microRNAs as Hormones: Intercellular and Inter-organ Conveyors of Epigenetic Information?. Experientia supplementum (2012), 106255-267. https://doi.org/10.1007/978-3-0348-0955-9_12
Yoshioka, Yusuke, et al. "Circulating microRNAs as Hormones: Intercellular and Inter-organ Conveyors of Epigenetic Information?." Experientia supplementum (2012) vol. 106 (2015): 255-267. doi: https://doi.org/10.1007/978-3-0348-0955-9_12
Yoshioka Y, Katsuda T, Ochiya T. Circulating microRNAs as Hormones: Intercellular and Inter-organ Conveyors of Epigenetic Information?. Exp Suppl. 2015;106:255-267. doi: 10.1007/978-3-0348-0955-9_12. PMID: 26608208.
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Exp Suppl. 2015;106:255-267. doi: 10.1007/978-3-0348-0955-9_12.

Circulating microRNAs as Hormones: Intercellular and Inter-organ Conveyors of Epigenetic Information?.

Experientia supplementum (2012)

Yusuke Yoshioka, Takeshi Katsuda, Takahiro Ochiya

Affiliations

  1. Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  2. Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. [email protected].

PMID: 26608208 DOI: 10.1007/978-3-0348-0955-9_12

Abstract

The discovery of microRNAs (miRNAs) has created a paradigm shift not only in the traditional central dogma of molecular biology but also in the research of a variety of human diseases. Fourteen years after the discovery of miRNAs, there was another revolutionary finding: cells can shuttle miRNAs between each other via small lipid bilayer vesicles called exosomes. This exosome-mediated horizontal transfer of genetically encoded messages is now recognized as a means of intercellular communication. This chapter reviews the concept that miRNAs can function as hormones conveying epigenetic information.

Keywords: Cell-to-cell communication; Circulating miRNAs; Exosome; Extracellular vesicles; miRNA

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