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Subramaniam A, Agarwal SM, Kalmady S, et al. Effect of Transcranial Direct Current Stimulation on Prefrontal Inhibition in Schizophrenia Patients with Persistent Auditory Hallucinations: A Study on Antisaccade Task Performance. Indian J Psychol Med. 2015;37(4):419-22doi: 10.4103/0253-7176.168584.
Subramaniam, A., Agarwal, S. M., Kalmady, S., Shivakumar, V., Chhabra, H., Bose, A., Damodharan, D., Narayanaswamy, J. C., Hutton, S. B., & Venkatasubramanian, G. (2015). Effect of Transcranial Direct Current Stimulation on Prefrontal Inhibition in Schizophrenia Patients with Persistent Auditory Hallucinations: A Study on Antisaccade Task Performance. Indian journal of psychological medicine, 37(4), 419-22. https://doi.org/10.4103/0253-7176.168584
Subramaniam, Aditi, et al. "Effect of Transcranial Direct Current Stimulation on Prefrontal Inhibition in Schizophrenia Patients with Persistent Auditory Hallucinations: A Study on Antisaccade Task Performance." Indian journal of psychological medicine vol. 37,4 (2015): 419-22. doi: https://doi.org/10.4103/0253-7176.168584
Subramaniam A, Agarwal SM, Kalmady S, Shivakumar V, Chhabra H, Bose A, Damodharan D, Narayanaswamy JC, Hutton SB, Venkatasubramanian G. Effect of Transcranial Direct Current Stimulation on Prefrontal Inhibition in Schizophrenia Patients with Persistent Auditory Hallucinations: A Study on Antisaccade Task Performance. Indian J Psychol Med. 2015 Oct-Dec;37(4):419-22. doi: 10.4103/0253-7176.168584. PMID: 26702174; PMCID: PMC4676208.
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Indian J Psychol Med. 2015 Oct-Dec;37(4):419-22. doi: 10.4103/0253-7176.168584.

Effect of Transcranial Direct Current Stimulation on Prefrontal Inhibition in Schizophrenia Patients with Persistent Auditory Hallucinations: A Study on Antisaccade Task Performance.

Indian journal of psychological medicine

Aditi Subramaniam, Sri Mahavir Agarwal, Sunil Kalmady, Venkataram Shivakumar, Harleen Chhabra, Anushree Bose, Dinakaran Damodharan, Janardhanan C Narayanaswamy, Sam B Hutton, Ganesan Venkatasubramanian

Affiliations

  1. Department of Psychiatry, The Schizophrenia Clinic, Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
  2. University of Sussex, Brighton, United Kingdom.

PMID: 26702174 PMCID: PMC4676208 DOI: 10.4103/0253-7176.168584

Abstract

BACKGROUND: Deficient prefrontal cortex inhibitory control is of particular interest with regard to the pathogenesis of auditory hallucinations (AHs) in schizophrenia. Antisaccade task performance is a sensitive index of prefrontal inhibitory function and has been consistently found to be abnormal in schizophrenia.

METHODS: This study investigated the effect of transcranial direct current stimulation (tDCS) on antisaccade performance in 13 schizophrenia patients.

RESULTS: The tDCS resulted in significant reduction in antisaccade error percentage (t = 3.4; P = 0.005), final eye position gain (t = 2.3; P = 0.042), and AHs severity (t = 4.1; P = 0.003).

CONCLUSION: Our results raise the possibility that improvement in antisaccade performance and severity of AH may be mechanistically related.

Keywords: Antisaccade; hallucinations; schizophrenia; transcranial direct current stimulation

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