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Farhan M, Hoda MQ, Ullah H. Prevention of hypotension associated with the induction dose of propofol: A randomized controlled trial comparing equipotent doses of phenylephrine and ephedrine. J Anaesthesiol Clin Pharmacol. 2015;31(4):526-30doi: 10.4103/0970-9185.169083.
Farhan, M., Hoda, M. Q., & Ullah, H. (2015). Prevention of hypotension associated with the induction dose of propofol: A randomized controlled trial comparing equipotent doses of phenylephrine and ephedrine. Journal of anaesthesiology, clinical pharmacology, 31(4), 526-30. https://doi.org/10.4103/0970-9185.169083
Farhan, Muhammad, et al. "Prevention of hypotension associated with the induction dose of propofol: A randomized controlled trial comparing equipotent doses of phenylephrine and ephedrine." Journal of anaesthesiology, clinical pharmacology vol. 31,4 (2015): 526-30. doi: https://doi.org/10.4103/0970-9185.169083
Farhan M, Hoda MQ, Ullah H. Prevention of hypotension associated with the induction dose of propofol: A randomized controlled trial comparing equipotent doses of phenylephrine and ephedrine. J Anaesthesiol Clin Pharmacol. 2015 Oct-Dec;31(4):526-30. doi: 10.4103/0970-9185.169083. PMID: 26702213; PMCID: PMC4676245.
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J Anaesthesiol Clin Pharmacol. 2015 Oct-Dec;31(4):526-30. doi: 10.4103/0970-9185.169083.

Prevention of hypotension associated with the induction dose of propofol: A randomized controlled trial comparing equipotent doses of phenylephrine and ephedrine.

Journal of anaesthesiology, clinical pharmacology

Muhammad Farhan, Muhammad Qamarul Hoda, Hameed Ullah

Affiliations

  1. Department of Anesthesiology, The Aga Khan University Hospital, Karachi, Pakistan.

PMID: 26702213 PMCID: PMC4676245 DOI: 10.4103/0970-9185.169083

Abstract

BACKGROUND AND AIMS: Propofol, the most commonly used intravenous (IV) anesthetic agent is associated with hypotension on induction of anesthesia. Different methods have been used to prevent hypotension but with variable results. The objective of this study was to evaluate efficacy of equipotent doses of phenylpehrine and ephedrine in preventing the hypotensive response to the induction dose of propofol.

MATERIAL AND METHODS: One hundred thirty five adult patients were randomised to one of the study groups: propofol-saline (PS), propofol-phenylephrine (PP) or propofol-ephedrine (PE) by adding study drugs to propofol. Anesthesia was induced with a mixture of propofol and the study drug. Patients were manually mask-ventilated for 5 min using 40% oxygen in nitrous oxide and isoflurane at 1%. A baseline mean arterial pressure (MAP) was recorded prior to induction of anesthesia. Systolic, diastolic and mean blood pressure and heart rate were recorded every minute for up to 5 min after induction. Hypotension was defined as a 20% decrease from the baseline MAP.

RESULTS: There were no significant demographic differences between the groups. Overall incidence of hypotension in this study was 38.5% (52/135). Rate of hypotension was significantly higher in group PS than group PP (60% vs. 24.4% P = 0.001) and group PE (60% vs. 31.1% P = 0.005). In contrast, a significant difference in rate of hypotension was not observed between groups PP and group PE.

CONCLUSION: In equipotent doses, phenylephrine is as good as ephedrine in preventing the hypotensive response to an induction dose of propofol.

Keywords: Ephedrine; hypotension; induction; phenylephrine; propofol

References

  1. Anaesthesia. 1988 Mar;43 Suppl:25-31 - PubMed
  2. J Pak Med Assoc. 2007 Nov;57(11):543-7 - PubMed
  3. Anaesth Intensive Care. 1999 Oct;27(5):477-80 - PubMed
  4. Int Anesthesiol Clin. 1988 Summer;26(2):98-104 - PubMed
  5. Br J Anaesth. 2006 Jan;96(1):95-9 - PubMed
  6. Br J Anaesth. 1988 Jan;60(1):3-9 - PubMed
  7. Can J Anaesth. 1999 Apr;46(4):342-7 - PubMed
  8. Nepal Med Coll J. 2008 Mar;10(1):16-9 - PubMed
  9. Anesthesiology. 1994 Mar;80(3):534-44 - PubMed
  10. Br J Anaesth. 1991 Nov;67(5):618-20 - PubMed
  11. Am J Health Syst Pharm. 1997 Jun 1;54(11):1287-92 - PubMed
  12. Anesthesiology. 1992 May;76(5):725-33 - PubMed
  13. J Coll Physicians Surg Pak. 2007 Jul;17(7):390-3 - PubMed
  14. Anesth Analg. 1998 Mar;86(3):477-81 - PubMed
  15. Br J Anaesth. 1998 Jun;80(6):737-41 - PubMed
  16. Anesthesiology. 1997 Jan;86(1):64-72 - PubMed

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