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Ohwatashi A, Ikeda S, Harada K, et al. Exercise enhanced functional recovery and expression of GDNF after photochemically induced cerebral infarction in the rat. EXCLI J. 2013;12:693-700
Ohwatashi, A., Ikeda, S., Harada, K., Kamikawa, Y., & Yoshida, A. (2013). Exercise enhanced functional recovery and expression of GDNF after photochemically induced cerebral infarction in the rat. EXCLI journal, 12693-700.
Ohwatashi, Akihiko, et al. "Exercise enhanced functional recovery and expression of GDNF after photochemically induced cerebral infarction in the rat." EXCLI journal vol. 12 (2013): 693-700.
Ohwatashi A, Ikeda S, Harada K, Kamikawa Y, Yoshida A. Exercise enhanced functional recovery and expression of GDNF after photochemically induced cerebral infarction in the rat. EXCLI J. 2013 Aug 14;12:693-700. eCollection 2013. PMID: 26600736; PMCID: PMC4653718.
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EXCLI J. 2013 Aug 14;12:693-700. eCollection 2013.

Exercise enhanced functional recovery and expression of GDNF after photochemically induced cerebral infarction in the rat.

EXCLI journal

Akihiko Ohwatashi, Satoshi Ikeda, Katsuhiro Harada, Yurie Kamikawa, Akira Yoshida

Affiliations

  1. Department of Rehabilitation and Physical Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan ; School of Medical Sciences, Faculty of Medicine, Kagoshima University, Kagoshima, Japan.
  2. Department of Rehabilitation and Physical Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

PMID: 26600736 PMCID: PMC4653718

Abstract

Exercise has been considered to affect the functional recovery from central nervous damage. Neurotrophic factors have various effects on brain damage. However, the effects of exercise for expression of GDNF on functional recovery with brain damage are not well known. We investigated the difference in functional recovery between non-exercise and beam-walking exercise groups, and the expression of GDNF in both groups after photochemical infarction. Adult male Wistar rats (N = 64) were used. Animals were divided into two groups: non-exercise (N = 35), and beam-walking exercise (N = 29). All rats underwent surgical photochemical infarction. The rats of the beam-walking group were trained every day to walk on a narrow beam after a one-day recovery period and those of the non-exercise group were left to follow a natural course. Animals were evaluated for hind limb function every day using a beam-walking task with an elevated narrow beam. The number of GDNF-like immunoreactive cells in the temporal cortex surrounding the lesion was counted 1, 3, 5, and 7 days after the infarction. Functional recovery of the beam-walking exercise group was significantly earlier than that of the non-exercise group. At 3 days after infarction, the number of GDNF-positive cells in the temporal cortex surrounding the infarction was significantly increased in the beam-walking exercise group compared with that in the non-exercise group. In the exercise group, motor function was remarkably recovered with the increased expression of GDNF-like immunoreactive cells. Our results suggested that a rehabilitative approach increased the expression of GDNF and facilitated functional recovery from cerebral infarction.

Keywords: beam-walking exercise; cerebral infarction; cortical plasticity; functional recovery; glial cell line-derived neurotrophic factor; photochemical infarction

References

  1. Neuroscience. 2004;123(3):667-74 - PubMed
  2. J Neurosci. 1999 Nov 15;19(22):10153-63 - PubMed
  3. J Neurochem. 2003 Nov;87(3):586-97 - PubMed
  4. Exp Neurol. 1996 Jun;139(2):322-7 - PubMed
  5. J Neurosci. 1997 Jun 1;17(11):4341-8 - PubMed
  6. Brain Res. 2005 Aug 2;1052(1):16-21 - PubMed
  7. Nat Neurosci. 2007 Mar;10(3):293-300 - PubMed
  8. Trends Neurosci. 1999 Sep;22(9):391-7 - PubMed
  9. Physiol Behav. 2003 Nov;80(2-3):167-75 - PubMed
  10. Trends Neurosci. 2003 May;26(5):248-54 - PubMed
  11. Stroke. 2004 Apr;35(4):992-7 - PubMed
  12. Neuroreport. 2001 May 25;12(7):1543-7 - PubMed
  13. Ann Neurol. 1985 May;17(5):497-504 - PubMed
  14. Int J Neurosci. 2007 Mar;117(3):315-26 - PubMed
  15. Neurosci Lett. 2003 Mar 20;339(2):91-4 - PubMed
  16. Neurosignals. 2006-2007;15(2):102-10 - PubMed
  17. Science. 1982 Aug 27;217(4562):855-7 - PubMed
  18. Acta Neuropathol. 1987;72(4):315-25 - PubMed
  19. Neurol Res. 2002 Dec;24(8):829-36 - PubMed
  20. Brain Res. 2002 Apr 26;934(1):1-6 - PubMed
  21. Stroke. 1996 Feb;27(2):324-6 - PubMed
  22. Brain Res Bull. 2002 Jul;58(3):315-21 - PubMed
  23. Neuroscience. 2001;106(1):27-41 - PubMed
  24. Neuroscience. 1999;89(4):1367-77 - PubMed
  25. Neurosci Lett. 2003 Nov 27;352(1):33-6 - PubMed
  26. Gerontology. 2005 May-Jun;51(3):161-5 - PubMed
  27. Can J Neurol Sci. 2003 Aug;30(3):252-8 - PubMed
  28. J Neurosci. 2001 Jul 15;21(14):5272-80 - PubMed

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