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Pichon A, Bézier A, Urbach S, et al. Recurrent DNA virus domestication leading to different parasite virulence strategies. Sci Adv. 2015;1(10):e1501150doi: 10.1126/sciadv.1501150.
Pichon, A., Bézier, A., Urbach, S., Aury, J. M., Jouan, V., Ravallec, M., Guy, J., Cousserans, F., Thézé, J., Gauthier, J., Demettre, E., Schmieder, S., Wurmser, F., Sibut, V., Poirié, M., Colinet, D., da Silva, C., Couloux, A., Barbe, V., Drezen, J. M., & Volkoff, A. N. (2015). Recurrent DNA virus domestication leading to different parasite virulence strategies. Science advances, 1(10), e1501150. https://doi.org/10.1126/sciadv.1501150
Pichon, Apolline, et al. "Recurrent DNA virus domestication leading to different parasite virulence strategies." Science advances vol. 1,10 (2015): e1501150. doi: https://doi.org/10.1126/sciadv.1501150
Pichon A, Bézier A, Urbach S, Aury JM, Jouan V, Ravallec M, Guy J, Cousserans F, Thézé J, Gauthier J, Demettre E, Schmieder S, Wurmser F, Sibut V, Poirié M, Colinet D, da Silva C, Couloux A, Barbe V, Drezen JM, Volkoff AN. Recurrent DNA virus domestication leading to different parasite virulence strategies. Sci Adv. 2015 Nov 27;1(10):e1501150. doi: 10.1126/sciadv.1501150. eCollection 2015 Nov. PMID: 26702449; PMCID: PMC4681339.
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Sci Adv. 2015 Nov 27;1(10):e1501150. doi: 10.1126/sciadv.1501150. eCollection 2015 Nov.

Recurrent DNA virus domestication leading to different parasite virulence strategies.

Science advances

Apolline Pichon, Annie Bézier, Serge Urbach, Jean-Marc Aury, Véronique Jouan, Marc Ravallec, Julie Guy, François Cousserans, Julien Thézé, Jérémy Gauthier, Edith Demettre, Sandra Schmieder, François Wurmser, Vonick Sibut, Marylène Poirié, Dominique Colinet, Corinne da Silva, Arnaud Couloux, Valérie Barbe, Jean-Michel Drezen, Anne-Nathalie Volkoff

Affiliations

  1. Microorganism and Insect Diversity, Genomes, and Interactions (DGIMI) Laboratory, UMR 1333 INRA, Université de Montpellier, Place Eugène Bataillon, CC101, Montpellier Cedex 34095, France.
  2. Institut de Recherche sur la Biologie de l'Insecte (IRBI), UMR 7261, CNRS-Université François Rabelais de Tours, Parc de Grandmont, Tours 37200, France.
  3. Functional Proteomics Platform, BioCampus Montpellier, UMS CNRS 3426, INSERM US009, Institut de Génomique Fonctionnelle, UMR CNRS 5203, INSERM U661, Université de Montpellier, Montpellier 34094, France.
  4. Commissariat à l'Energie Atomique (CEA), Institut de Génomique (IG), Genoscope, 2 rue Gaston Crémieux, BP5706, Evry 91057, France.
  5. Institut Sophia Agrobiotech (ISA), UMR INRA 1355, CNRS 7254, Université Nice Sophia Antipolis, 400 route des Chappes, Sophia Antipolis 06903, France.
  6. PPF Analyse des systèmes biologiques, Université François Rabelais de Tours, 3 Boulevard Tonnellé, Tours 37000, France.

PMID: 26702449 PMCID: PMC4681339 DOI: 10.1126/sciadv.1501150

Abstract

Relics of ancient infections are abundant in eukaryote genomes, but little is known about how they evolve when they confer a functional benefit on their host. We show here, for the first time, that the virus-like particles shown to protect Venturia canescens eggs against host immunity are derived from a nudivirus genome incorporated by the parasitic wasp into its own genetic material. Nudivirus hijacking was also at the origin of protective particles from braconid wasps. However, we show here that the viral genes produce "liposomes" that wrap and deliver V. canescens virulence proteins, whereas the particles are used as gene transfer agents in braconid wasps. Our findings indicate that virus domestication has occurred repeatedly during parasitic wasp evolution but with different evolutionary trajectories after endogenization, resulting in different virulence molecule delivery strategies.

Keywords: Microbiology; genomes; virus domestication; wasps

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