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Burada F, Nicoli ER, Ciurea ME, et al. Autophagy in colorectal cancer: An important switch from physiology to pathology. World J Gastrointest Oncol. 2015;7(11):271-84doi: 10.4251/wjgo.v7.i11.271.
Burada, F., Nicoli, E. R., Ciurea, M. E., Uscatu, D. C., Ioana, M., & Gheonea, D. I. (2015). Autophagy in colorectal cancer: An important switch from physiology to pathology. World journal of gastrointestinal oncology, 7(11), 271-84. https://doi.org/10.4251/wjgo.v7.i11.271
Burada, Florin, et al. "Autophagy in colorectal cancer: An important switch from physiology to pathology." World journal of gastrointestinal oncology vol. 7,11 (2015): 271-84. doi: https://doi.org/10.4251/wjgo.v7.i11.271
Burada F, Nicoli ER, Ciurea ME, Uscatu DC, Ioana M, Gheonea DI. Autophagy in colorectal cancer: An important switch from physiology to pathology. World J Gastrointest Oncol. 2015 Nov 15;7(11):271-84. doi: 10.4251/wjgo.v7.i11.271. PMID: 26600927; PMCID: PMC4644850.
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World J Gastrointest Oncol. 2015 Nov 15;7(11):271-84. doi: 10.4251/wjgo.v7.i11.271.

Autophagy in colorectal cancer: An important switch from physiology to pathology.

World journal of gastrointestinal oncology

Florin Burada, Elena Raluca Nicoli, Marius Eugen Ciurea, Daniel Constantin Uscatu, Mihai Ioana, Dan Ionut Gheonea

Affiliations

  1. Florin Burada, Marius Eugen Ciurea, Mihai Ioana, Dan Ionut Gheonea, Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, 200638 Craiova, Romania.

PMID: 26600927 PMCID: PMC4644850 DOI: 10.4251/wjgo.v7.i11.271

Abstract

Colorectal cancer (CRC) remains a leading cause of cancer death in both men and women worldwide. Among the factors and mechanisms that are involved in the multifactorial etiology of CRC, autophagy is an important transformational switch that occurs when a cell shifts from normal to malignant. In recent years, multiple hypotheses have been considered regarding the autophagy mechanisms that are involved in cancer. The currently accepted hypothesis is that autophagy has dual and contradictory roles in carcinogenesis, but the precise mechanisms leading to autophagy in cancer are not yet fully defined and seem to be context dependent. Autophagy is a surveillance mechanism used by normal cells that protects them from the transformation to malignancy by removing damaged organelles and aggregated proteins and by reducing reactive oxygen species, mitochondrial abnormalities and DNA damage. However, autophagy also supports tumor formation by promoting access to nutrients that are critical to the metabolism and growth of tumor cells and by inhibiting cellular death and increasing drug resistance. Autophagy studies in CRC have focused on several molecules, mainly microtubule-associated protein 1 light chain 3, beclin 1, and autophagy related 5, with conflicting results. Beneficial effects were observed for some agents that modulate autophagy in CRC either alone or, more often, in combination with other agents. More extensive studies are needed in the future to clarify the roles of autophagy-related genes and modulators in colorectal carcinogenesis, and to develop potential beneficial agents for the prognosis and treatment of CRC.

Keywords: Autophagy; Carcinogenesis; Colorectal cancer; Gene; Protein

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