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Biomed Opt Express. 2015 Oct 14;6(11):4365-77. doi: 10.1364/BOE.6.004365. eCollection 2015 Nov 01.

Reproducibility of optical coherence tomography airway imaging.

Biomedical optics express

Miranda Kirby, Keishi Ohtani, Taylor Nickens, Rosa Maria Lopez Lisbona, Anthony M D Lee, Tawimas Shaipanich, Pierre Lane, Calum MacAulay, Stephen Lam, Harvey O Coxson

Affiliations

  1. Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada ; Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada.
  2. Department of Surgery, Tokyo Medical University, Tokyo, Japan.
  3. Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.
  4. Department of Respirology, Bellvitge University Hospital, l'Hospitalet de Llobregat, Barcelona, Spain.
  5. Imaging Unit, Integrative Oncology Department, British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada.
  6. Imaging Unit, Integrative Oncology Department, British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada ; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

PMID: 26601002 PMCID: PMC4646546 DOI: 10.1364/BOE.6.004365

Abstract

Optical coherence tomography (OCT) is a promising imaging technique to evaluate small airway remodeling. However, the short-term insertion-reinsertion reproducibility of OCT for evaluating the same bronchial pathway has yet to be established. We evaluated 74 OCT data sets from 38 current or former smokers twice within a single imaging session. Although the overall insertion-reinsertion airway wall thickness (WT) measurement coefficient of variation (CV) was moderate at 12%, much of the variability between repeat imaging was attributed to the observer; CV for repeated measurements of the same airway (intra-observer CV) was 9%. Therefore, reproducibility may be improved by introduction of automated analysis approaches suggesting that OCT has potential to be an in-vivo method for evaluating airway remodeling in future longitudinal and intervention studies.

Keywords: (170.0170) Medical optics and biotechnology; (170.4500) Optical coherence tomography

References

  1. Sports Med. 1998 Oct;26(4):217-38 - PubMed
  2. Laryngoscope. 2007 Dec;117(12):2206-12 - PubMed
  3. Chest. 2010 Oct;138(4):984-8 - PubMed
  4. Am J Respir Crit Care Med. 2011 Mar 1;183(5):612-9 - PubMed
  5. Am J Respir Crit Care Med. 1999 Nov;160(5 Pt 1):1468-72 - PubMed
  6. Am J Respir Crit Care Med. 2008 Jun 1;177(11):1201-6 - PubMed
  7. J Biomed Opt. 2009 Nov-Dec;14(6):060503 - PubMed
  8. Eur Respir J. 2004 Jun;23(6):932-46 - PubMed
  9. Biomed Opt Express. 2014 Feb 19;5(3):788-99 - PubMed
  10. Chest. 2013 Jan;143(1):64-74 - PubMed
  11. Eur Respir J. 2005 Nov;26(5):948-68 - PubMed
  12. Am J Respir Crit Care Med. 2006 Jan 15;173(2):226-33 - PubMed
  13. Eur Respir J. 2008 Feb;31(2):416-69 - PubMed
  14. N Engl J Med. 1968 Jun 20;278(25):1355-60 - PubMed
  15. Int J Pediatr Otorhinolaryngol. 2015 Jan;79(1):63-70 - PubMed
  16. J Magn Reson Imaging. 1997 May-Jun;7(3):538-43 - PubMed
  17. PLoS One. 2014 Jun 20;9(6):e100145 - PubMed
  18. Lung Cancer. 2005 Sep;49(3):387-94 - PubMed
  19. Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):813-8 - PubMed
  20. Am J Respir Crit Care Med. 2005 Jan 15;171(2):142-6 - PubMed

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