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Leung TS, Kapur K, Guilliam A, et al. Screening neonatal jaundice based on the sclera color of the eye using digital photography. Biomed Opt Express. 2015;6(11):4529-38doi: 10.1364/BOE.6.004529.
Leung, T. S., Kapur, K., Guilliam, A., Okell, J., Lim, B., MacDonald, L. W., & Meek, J. (2015). Screening neonatal jaundice based on the sclera color of the eye using digital photography. Biomedical optics express, 6(11), 4529-38. https://doi.org/10.1364/BOE.6.004529
Leung, Terence S, et al. "Screening neonatal jaundice based on the sclera color of the eye using digital photography." Biomedical optics express vol. 6,11 (2015): 4529-38. doi: https://doi.org/10.1364/BOE.6.004529
Leung TS, Kapur K, Guilliam A, Okell J, Lim B, MacDonald LW, Meek J. Screening neonatal jaundice based on the sclera color of the eye using digital photography. Biomed Opt Express. 2015 Oct 23;6(11):4529-38. doi: 10.1364/BOE.6.004529. eCollection 2015 Nov 01. PMID: 26601015; PMCID: PMC4646559.
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Biomed Opt Express. 2015 Oct 23;6(11):4529-38. doi: 10.1364/BOE.6.004529. eCollection 2015 Nov 01.

Screening neonatal jaundice based on the sclera color of the eye using digital photography.

Biomedical optics express

Terence S Leung, Karan Kapur, Ashley Guilliam, Jade Okell, Bee Lim, Lindsay W MacDonald, Judith Meek

Affiliations

  1. Department of Medical Physics & Biomedical Engineering, University College London, UK.
  2. The Neonatal Care Unit, Elizabeth Garrett Anderson Wing, University College London Hospitals Trust, UK.
  3. Department of Civil, Environmental & Geomatic Engineering, University College London, UK.

PMID: 26601015 PMCID: PMC4646559 DOI: 10.1364/BOE.6.004529

Abstract

A new screening technique for neonatal jaundice is proposed exploiting the yellow discoloration in the sclera. It involves taking digital photographs of newborn infants' eyes (n = 110) and processing the pixel colour values of the sclera to predict the total serum bilirubin (TSB) levels. This technique has linear and rank correlation coefficients of 0.75 and 0.72 (both p<0.01) with the measured TSB. The mean difference ( ± SD) is 0.00 ± 41.60 µmol/l. The receiver operating characteristic curve shows that this technique can identify subjects with TSB above 205 µmol/l with sensitivity of 1.00 and specificity of 0.50, showing its potential as a screening device.

Keywords: (300.6550) Spectroscopy, visible; (330.1710) Color, measurement

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