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Khetani A, Momenpour A, Alarcon EI, et al. Hollow core photonic crystal fiber for monitoring leukemia cells using surface enhanced Raman scattering (SERS). Biomed Opt Express. 2015;6(11):4599-609doi: 10.1364/BOE.6.004599.
Khetani, A., Momenpour, A., Alarcon, E. I., & Anis, H. (2015). Hollow core photonic crystal fiber for monitoring leukemia cells using surface enhanced Raman scattering (SERS). Biomedical optics express, 6(11), 4599-609. https://doi.org/10.1364/BOE.6.004599
Khetani, Altaf, et al. "Hollow core photonic crystal fiber for monitoring leukemia cells using surface enhanced Raman scattering (SERS)." Biomedical optics express vol. 6,11 (2015): 4599-609. doi: https://doi.org/10.1364/BOE.6.004599
Khetani A, Momenpour A, Alarcon EI, Anis H. Hollow core photonic crystal fiber for monitoring leukemia cells using surface enhanced Raman scattering (SERS). Biomed Opt Express. 2015 Oct 28;6(11):4599-609. doi: 10.1364/BOE.6.004599. eCollection 2015 Nov 01. PMID: 26601021; PMCID: PMC4646565.
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Biomed Opt Express. 2015 Oct 28;6(11):4599-609. doi: 10.1364/BOE.6.004599. eCollection 2015 Nov 01.

Hollow core photonic crystal fiber for monitoring leukemia cells using surface enhanced Raman scattering (SERS).

Biomedical optics express

Altaf Khetani, Ali Momenpour, Emilio I Alarcon, Hanan Anis

Affiliations

  1. School of Electrical Engineering and Computer Science (EECS), University of Ottawa, Ottawa, ON K1N 6N5, Canada.
  2. University of Ottawa Heart Institute, Division of Cardiac Surgery Research, 40 Ruskin Street, Ottawa, ON K1Y 4W7 Canada.

PMID: 26601021 PMCID: PMC4646565 DOI: 10.1364/BOE.6.004599

Abstract

The present paper demonstrates an antibody-free, robust, fast, and portable platform for detection of leukemia cells using Raman spectroscopy with a 785-nm laser diode coupled to a hollow core photonic crystal (HC-PCF) containing silver nanoparticles. Acute myeloid leukemia is one of the most common bone marrow cancers in children and youths. Clinical studies suggest that early diagnosis and remission evaluation of myoblasts in the bone marrow are pivotal for improving patient survival. However, the current protocols for leukemic cells detection involve the use of expensive antibodies and flow cytometers. Thus, we have developed a new technology for detection of leukemia cells up to 300 cells/ml using a compact fiber HC-PCF, which offers a novel alternative to existing clinical standards. Furthermore, we were also able to accurately distinguish live, apoptotic and necrotic leukemic cells.

Keywords: (060.5295) Photonic crystal fibers; (170.1530) Cell analysis; (170.5660) Raman spectroscopy; (240.6695) Surface-enhanced Raman scattering; (280.4788) Optical sensing and sensors

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