Display options
Cite
Cupisti A, Vigo V, Baronti ME, et al. Vitamin D status and cholecalciferol supplementation in chronic kidney disease patients: an Italian cohort report. Int J Nephrol Renovasc Dis. 2015;8:151-7doi: 10.2147/IJNRD.S90968.
Cupisti, A., Vigo, V., Baronti, M. E., D'Alessandro, C., Ghiadoni, L., & Egidi, M. F. (2015). Vitamin D status and cholecalciferol supplementation in chronic kidney disease patients: an Italian cohort report. International journal of nephrology and renovascular disease, 8151-7. https://doi.org/10.2147/IJNRD.S90968
Cupisti, Adamasco, et al. "Vitamin D status and cholecalciferol supplementation in chronic kidney disease patients: an Italian cohort report." International journal of nephrology and renovascular disease vol. 8 (2015): 151-7. doi: https://doi.org/10.2147/IJNRD.S90968
Cupisti A, Vigo V, Baronti ME, D'Alessandro C, Ghiadoni L, Egidi MF. Vitamin D status and cholecalciferol supplementation in chronic kidney disease patients: an Italian cohort report. Int J Nephrol Renovasc Dis. 2015 Nov 19;8:151-7. doi: 10.2147/IJNRD.S90968. eCollection 2015. PMID: 26640388; PMCID: PMC4657801.
Copy Download .nbib Format: NLM
Share it on

Int J Nephrol Renovasc Dis. 2015 Nov 19;8:151-7. doi: 10.2147/IJNRD.S90968. eCollection 2015.

Vitamin D status and cholecalciferol supplementation in chronic kidney disease patients: an Italian cohort report.

International journal of nephrology and renovascular disease

Adamasco Cupisti, Valentina Vigo, Maria Enrica Baronti, Claudia D'Alessandro, Lorenzo Ghiadoni, Maria Francesca Egidi

Affiliations

  1. Nephrology, Transplant and Dialysis Division, AOUP, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

PMID: 26640388 PMCID: PMC4657801 DOI: 10.2147/IJNRD.S90968

Abstract

This study investigated the factors associated with hypovitaminosis D, in a cohort of 405 prevalent patients with chronic kidney disease (CKD) stages 2-4, living in Italy and followed-up in tertiary care. The effect of cholecalciferol 10,000 IU once-a-week for 12 months was evaluated in a subgroup of 100 consecutive patients with hypovitaminosis D. Vitamin D deficiency was observed in 269 patients (66.4%) whereas vitamin D insufficiency was found in 67 patients (16.5%). In diabetic patients, 25-hydroxyvitamin D deficiency was detected in 80% of cases. In patients older than 65 years, the prevalence of hypovitaminosis D was 89%. In the univariate analysis, 25-hydroxyvitamin D was negatively related to age, parathyroid hormone (PTH), proteinuria, and Charlson index, while a positive relationship has emerged with hemoglobin level. On multiple regression analysis, only age and PTH levels were independently associated with 25-hydroxyvitamin D levels. No relationship emerged between vitamin D deficiency and renal function. Serum levels of 25-hydroxyvitamin D or prevalence of hypovitaminosis D did not differ between patients on a free-choice diet and on a renal diet, including low-protein, low-phosphorus regimens. Twelve-month oral cholecalciferol administration increased 25-hydroxyvitamin D and reduced PTH serum levels. In summary, hypovitaminosis D is very prevalent in CKD patients (83%) in Italy, and it is similar to other locations. PTH serum levels and age, but not renal function, are the major correlates of hypovitaminosis D. Implementation of renal diets is not associated with higher risk of vitamin D depletion. Oral cholecalciferol administration increased 25-hydroxyvitamin D and mildly reduced PTH serum levels. Oral cholecalciferol supplementation should be recommended as a regular practice in CKD patients, also when serum 25-hydroxyvitamin D determination is not available or feasible.

Keywords: CKD; CKD-MBD; PTH; calcifediol; cholecalciferol; hypovitaminosis; renal disease; vitamin D

References

  1. N Engl J Med. 2007 Jul 19;357(3):266-81 - PubMed
  2. Am J Kidney Dis. 2007 Jul;50(1):59-68 - PubMed
  3. Am J Nephrol. 2007;27(1):36-43 - PubMed
  4. Endocr Pract. 2008 Jan-Feb;14 (1):10-7 - PubMed
  5. Semin Dial. 2013 Nov-Dec;26(6):714-9 - PubMed
  6. J Ren Nutr. 2014 Sep;24(5):303-12 - PubMed
  7. Clin J Am Soc Nephrol. 2013 Nov;8(11):1870-6 - PubMed
  8. J Nephrol Ther. 2014 May 15;4(3):null - PubMed
  9. Kidney Blood Press Res. 2013;37(6):667-78 - PubMed
  10. Nephrology (Carlton). 2006 Dec;11(6):555-9 - PubMed
  11. Clin J Am Soc Nephrol. 2008 Jul;3(4):1144-51 - PubMed
  12. Ren Fail. 2011;33(2):184-91 - PubMed
  13. Kidney Int. 2010 Apr;77(8):715-20 - PubMed
  14. J Ren Nutr. 2012 Jan;22(1):4-11 - PubMed
  15. J Ren Nutr. 2009 Jan;19(1):38-43 - PubMed
  16. J Ren Nutr. 2014 May;24(3):186-93 - PubMed
  17. J Ren Nutr. 2014 Jan;24(1):20-5 - PubMed
  18. BMC Nephrol. 2013 Sep 25;14:199 - PubMed
  19. Kidney Int. 2007 Jan;71(1):31-8 - PubMed
  20. Nutrition. 2014 Sep;30(9):992-9 - PubMed
  21. Curr Vasc Pharmacol. 2014 Mar;12(2):339-49 - PubMed
  22. J Ren Nutr. 2014 Jan;24(1):61-2 - PubMed

Publication Types