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Prasad C, Imrhan V, Juma S, et al. Bioactive Plant Metabolites in the Management of Non-Communicable Metabolic Diseases: Looking at Opportunities beyond the Horizon. Metabolites. 2015;5(4):733-65doi: 10.3390/metabo5040733.
Prasad, C., Imrhan, V., Juma, S., Maziarz, M., Prasad, A., Tiernan, C., & Vijayagopal, P. (2015). Bioactive Plant Metabolites in the Management of Non-Communicable Metabolic Diseases: Looking at Opportunities beyond the Horizon. Metabolites, 5(4), 733-65. https://doi.org/10.3390/metabo5040733
Prasad, Chandan, et al. "Bioactive Plant Metabolites in the Management of Non-Communicable Metabolic Diseases: Looking at Opportunities beyond the Horizon." Metabolites vol. 5,4 (2015): 733-65. doi: https://doi.org/10.3390/metabo5040733
Prasad C, Imrhan V, Juma S, Maziarz M, Prasad A, Tiernan C, Vijayagopal P. Bioactive Plant Metabolites in the Management of Non-Communicable Metabolic Diseases: Looking at Opportunities beyond the Horizon. Metabolites. 2015 Dec 12;5(4):733-65. doi: 10.3390/metabo5040733. PMID: 26703752; PMCID: PMC4693193.
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Metabolites. 2015 Dec 12;5(4):733-65. doi: 10.3390/metabo5040733.

Bioactive Plant Metabolites in the Management of Non-Communicable Metabolic Diseases: Looking at Opportunities beyond the Horizon.

Metabolites

Chandan Prasad, Victorine Imrhan, Shanil Juma, Mindy Maziarz, Anand Prasad, Casey Tiernan, Parakat Vijayagopal

Affiliations

  1. Department of Nutrition and Food Sciences, Texas Woman's University, Denton, TX 76204, USA. [email protected].
  2. Department of Medicine, LSU Health Sciences Center, New Orleans, LA 70112, USA. [email protected].
  3. Department of Nutrition and Food Sciences, Texas Woman's University, Denton, TX 76204, USA. [email protected].
  4. Department of Nutrition and Food Sciences, Texas Woman's University, Denton, TX 76204, USA. [email protected].
  5. Department of Nutrition and Food Sciences, Texas Woman's University, Houston, TX 77030, USA. [email protected].
  6. Department of Medicine, Division of Cardiology, UT Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA. [email protected].
  7. Department of Nutrition and Food Sciences, Texas Woman's University, Denton, TX 76204, USA. [email protected].
  8. Department of Nutrition and Food Sciences, Texas Woman's University, Denton, TX 76204, USA. [email protected].

PMID: 26703752 PMCID: PMC4693193 DOI: 10.3390/metabo5040733

Abstract

There has been an unprecedented worldwide rise in non-communicable metabolic diseases (NCDs), particularly cardiovascular diseases (CVD) and diabetes. While modern pharmacotherapy has decreased the mortality in the existing population, it has failed to stem the rise. Furthermore, a large segment of the world population cannot afford expensive pharmacotherapy. Therefore, there is an urgent need for inexpensive preventive measures to control the rise in CVD and diabetes and associated co-morbidities. The purpose of this review is to explore the role of food bioactives in prevention of NCDs. To this end, we have critically analyzed the possible utility of three classes of food bioactives: (a) resistant starch, a metabolically resistant carbohydrate known to favorably modulate insulin secretion and glucose metabolism; (b) cyclo (His-Pro), a food-derived cyclic dipeptides; and (c) polyphenol-rich berries. Finally, we have also briefly outlined the strategies needed to prepare these food-bioactives for human use.

Keywords: cardiovascular disease; cyclo (His-Pro); diabetes; food bioactives; functional food; polyphenols; resistant starch

References

  1. Analyst. 1982 Mar;107(1272):307-18 - PubMed
  2. Atherosclerosis. 2015 Jan;238(1):77-82 - PubMed
  3. Nutr Res. 2011 Nov;31(11):842-7 - PubMed
  4. Nutr Res. 2012 Jul;32(7):537-41 - PubMed
  5. Lancet. 1993 Feb 20;341(8843):454-7 - PubMed
  6. Br J Nutr. 2003 Jun;89 Suppl 1:S45-58 - PubMed
  7. Curr Atheroscler Rep. 2010 Jan;12(1):48-57 - PubMed
  8. Am J Clin Nutr. 2008 Feb;87(2):323-31 - PubMed
  9. J Am Coll Cardiol. 2014 Jun 17;63(23 ):2541-8 - PubMed
  10. Arch Intern Med. 1995 Feb 27;155(4):381-6 - PubMed
  11. Nutr Metab Cardiovasc Dis. 2011 Nov;21(11):851-6 - PubMed
  12. Brain Res. 1981 Apr 6;210(1-2):475-8 - PubMed
  13. Circulation. 2008 Nov 4;118(19):1913-4 - PubMed
  14. Nutrients. 2015 Sep 17;7(9):7965-77 - PubMed
  15. PLoS One. 2012;7(4):e35240 - PubMed
  16. N Engl J Med. 1995 Nov 16;333(20):1308-12 - PubMed
  17. Eur J Endocrinol. 2002 Jun;146(6):863-9 - PubMed
  18. Ann Intern Med. 2001 Jun 19;134(12):1106-14 - PubMed
  19. Am J Physiol Gastrointest Liver Physiol. 2002 Jun;282(6):G1009-15 - PubMed
  20. Cardiovasc Res. 2000 Aug 18;47(3):549-55 - PubMed
  21. Nutr Res. 2013 Mar;33(3):220-7 - PubMed
  22. Circulation. 2001 Jun 12;103(23):2792-8 - PubMed
  23. Health Aff (Millwood). 2005 May-Jun;24(3):611-21 - PubMed
  24. J Food Sci. 2011 Mar;76(2):C272-8 - PubMed
  25. J Agric Food Chem. 2004 Jul 14;52(14):4360-7 - PubMed
  26. Biochim Biophys Acta. 2015 Jun;1852(6):1145-54 - PubMed
  27. Ann N Y Acad Sci. 2003 Jun;994:162-8 - PubMed
  28. Nutr Res. 2014 Jul;34(7):577-84 - PubMed
  29. Phytomedicine. 2006 Nov;13(9-10):612-23 - PubMed
  30. Br J Nutr. 2015 Jul;114(2):220-30 - PubMed
  31. Food Nutr Res. 2012;56:null - PubMed
  32. Am J Epidemiol. 1999 May 15;149(10):943-9 - PubMed
  33. Peptides. 1995;16(1):151-64 - PubMed
  34. Eur J Clin Nutr. 1992 Oct;46 Suppl 2:S33-50 - PubMed
  35. N Am J Med Sci. 2015 Mar;7(3):86-93 - PubMed
  36. Mol Nutr Food Res. 2012 May;56(5):810-21 - PubMed
  37. Metabolism. 2005 Nov;54(11):1480-9 - PubMed
  38. Br J Nutr. 2012 Sep;108(5):900-9 - PubMed
  39. Circulation. 2014 Jun 24;129(25 Suppl 2):S76-99 - PubMed
  40. J Agric Food Chem. 2000 Feb;48(2):220-30 - PubMed
  41. Int J Epidemiol. 2002 Feb;31(1):218-26 - PubMed
  42. Br J Nutr. 2005 Apr;93 Suppl 1:S147-56 - PubMed
  43. World Rev Nutr Diet. 2000;87:90-113 - PubMed
  44. ISME J. 2010 Feb;4(2):232-41 - PubMed
  45. Biomed Environ Sci. 2015 Apr;28(4):291-7 - PubMed
  46. Cardiovasc Drugs Ther. 2005 Dec;19(6):403-14 - PubMed
  47. Crit Rev Food Sci Nutr. 2014;54(9):1158-66 - PubMed
  48. Am J Clin Nutr. 2013 Nov;98 (5):1179-91 - PubMed
  49. J Am Diet Assoc. 2008 Nov;108(11):1888-95 - PubMed
  50. N Engl J Med. 1996 May 2;334(18):1145-9 - PubMed
  51. PLoS One. 2014 Jun 04;9(6):e98611 - PubMed
  52. Am J Clin Nutr. 2011 Feb;93(2):338-47 - PubMed
  53. Endocr Connect. 2014 Apr 15;3(2):75-84 - PubMed
  54. J Nutr. 2010 Oct;140(10 ):1764-8 - PubMed
  55. Planta Med. 2005 Apr;71(4):287-94 - PubMed
  56. World J Diabetes. 2014 Dec 15;5(6):962-8 - PubMed
  57. J Am Coll Nutr. 2000 Jun;19(3 Suppl):326S-330S - PubMed
  58. J Hypertens. 2013 Sep;31(9):1819-27 - PubMed
  59. Br J Nutr. 2001 Aug;86(2):233-9 - PubMed
  60. Eur J Clin Nutr. 1998 Oct;52(10):733-6 - PubMed
  61. J Nutr. 2010 Sep;140(9):1582-7 - PubMed
  62. Diabetologia. 1994 Aug;37(8):773-80 - PubMed
  63. Am Health Drug Benefits. 2014 Nov;7(8):430-43 - PubMed
  64. Mol Nutr Food Res. 2014 Jun;58(6):1365-9 - PubMed
  65. J Natl Cancer Inst. 2004 Nov 3;96(21):1577-84 - PubMed
  66. Eur J Clin Nutr. 1999 Apr;53(4):319-27 - PubMed
  67. Nutrients. 2015 May 27;7(6):4107-23 - PubMed
  68. Lancet. 1990 Dec 8;336(8728):1455 - PubMed
  69. Lancet. 2013 Feb 16;381(9866):585-97 - PubMed
  70. Diabetes Care. 1998 Sep;21(9):1414-31 - PubMed
  71. Cell Metab. 2008 Feb;7(2):125-34 - PubMed
  72. Int J Sport Nutr Exerc Metab. 2014 Feb;24(1):2-13 - PubMed
  73. Free Radic Biol Med. 1996;20(7):933-56 - PubMed
  74. Arterioscler Thromb Vasc Biol. 2003 Apr 1;23(4):622-9 - PubMed
  75. Diabetes Care. 2013 Nov;36(11):3779-85 - PubMed
  76. Int J Epidemiol. 2001 Feb;30(1):130-5 - PubMed
  77. J Agric Food Chem. 2005 Jan 12;53(1):28-31 - PubMed
  78. Biosci Biotechnol Biochem. 2013;77(2):389-91 - PubMed
  79. J Nutr. 2012 Apr;142(4):717-23 - PubMed
  80. Int J Mol Sci. 2013 Nov 21;14(11):23063-85 - PubMed
  81. Nutr Metab Cardiovasc Dis. 2010 Jan;20(1):64-71 - PubMed
  82. J Lipid Res. 1995 Aug;36(8):1807-12 - PubMed
  83. Atherosclerosis. 1997 Nov;135(1):93-102 - PubMed
  84. Trans Assoc Am Physicians. 1983;96:131-6 - PubMed
  85. Endocrinology. 1981 May;108(5):1995-7 - PubMed
  86. J AOAC Int. 2004 May-Jun;87(3):733-9 - PubMed
  87. J Am Coll Cardiol. 2014 Jul 1;63(25 Pt B):2889-934 - PubMed
  88. J Nutr. 2001 May;131(5):1401-4 - PubMed
  89. Lancet. 2012 Dec 8;380(9858):1995-2006 - PubMed
  90. Biochem Biophys Res Commun. 2003 Oct 3;309(4):1017-26 - PubMed
  91. Fed Regist. 2000 Sep 8;65(175):54686-739 - PubMed
  92. Brain Res. 1995 Nov 13;699(1):149-53 - PubMed
  93. Lancet. 1981 Jul 4;2(8236):4-7 - PubMed
  94. Lancet. 2004 Jul 17-23;364(9430):257-62 - PubMed
  95. Br J Nutr. 2013 May 28;109(10):1746-54 - PubMed
  96. J Nutr. 2012 May;142(5):962-74 - PubMed
  97. Int J Cardiol. 2013 Jun 5;166(1):246-8 - PubMed
  98. Mayo Clin Proc. 2003 Aug;78(8):965-78 - PubMed
  99. Am J Med. 2002 Dec 30;113 Suppl 9B:71S-88S - PubMed
  100. J Nutr Biochem. 2012 Nov;23(11):1367-77 - PubMed
  101. Curr Opin Clin Nutr Metab Care. 2012 Jul;15(4):362-7 - PubMed
  102. Pharmacol Biochem Behav. 1991 Feb;38(2):359-64 - PubMed
  103. Lipids. 2004 Nov;39(11):1101-13 - PubMed
  104. BMJ. 2014 Jul 18;349:g4379 - PubMed
  105. Nutr Rev. 2006 Jul;64(7 Pt 1):348-54 - PubMed
  106. Eur Heart J. 2015 Sep 21;36(36):2415-24 - PubMed
  107. BMJ. 1996 Feb 24;312(7029):478-81 - PubMed
  108. Pharmacol Biochem Behav. 1991 Feb;38(2):365-9 - PubMed
  109. Diabetes Care. 2011 Jun;34(6):1249-57 - PubMed
  110. Food Chem. 2014 Aug 1;156:258-63 - PubMed
  111. Br J Nutr. 2006 Aug;96(2):357-64 - PubMed
  112. J Agric Food Chem. 2007 Feb 21;55(4):1337-46 - PubMed
  113. Pharmacol Biochem Behav. 1988 Feb;29(2):357-63 - PubMed
  114. Clin Cardiol. 2015 Jan;38(1):56-61 - PubMed
  115. Eur J Nutr. 2013 Sep;52(6):1569-78 - PubMed
  116. Biochim Biophys Acta. 2004 Aug 30;1664(2):161-71 - PubMed
  117. J Lipid Res. 2012 Dec;53(12 ):2515-24 - PubMed
  118. PLoS One. 2014 Dec 09;9(12):e114881 - PubMed
  119. J Agric Food Chem. 2005 Nov 30;53(24):9342-7 - PubMed
  120. Amino Acids. 2008 Aug;35(2):283-9 - PubMed
  121. J Am Assoc Nurse Pract. 2014 Feb;26(2):85-90 - PubMed
  122. Neuropeptides. 1990 Jan;15(1):55-9 - PubMed
  123. Lancet. 1965 Aug 28;2(7409):415-6 - PubMed
  124. J Am Coll Nutr. 1996 Jun;15(3):248-54 - PubMed
  125. Mol Nutr Food Res. 2005 May;49(5):405-30 - PubMed
  126. Nutr J. 2006 Sep 20;5:25 - PubMed
  127. Am J Clin Nutr. 2002 Jul;76(1):93-9 - PubMed
  128. J Nutr. 2009 Oct;139(10):1881-9 - PubMed
  129. J Clin Invest. 1987 Mar;79(3):875-80 - PubMed
  130. Plant Foods Hum Nutr. 2008 Dec;63(4):147-56 - PubMed
  131. Neurosci Biobehav Rev. 1988 Spring;12(1):19-22 - PubMed
  132. Am J Clin Nutr. 2005 Sep;82(3):559-67 - PubMed
  133. J Agric Food Chem. 2008 Nov 12;56(21):10099-104 - PubMed
  134. Am J Cardiol. 2005 Jul 4;96(1A):47D-50D - PubMed
  135. Trends Mol Med. 2014 Oct;20(10):551-8 - PubMed
  136. Lancet. 2004 Sep 11-17;364(9438):937-52 - PubMed
  137. Neuropeptides. 1989 Oct;14(3):185-9 - PubMed
  138. Metabolism. 2005 Jul;54(7):856-61 - PubMed
  139. J Clin Endocrinol Metab. 1992 Aug;75(2):375-8 - PubMed
  140. Br J Nutr. 2011 Aug;106(3):383-9 - PubMed
  141. Diabetologia. 1995 Mar;38(3):274-6 - PubMed
  142. Exp Biol Med (Maywood). 2003 Dec;228(11):1338-45 - PubMed
  143. Eur J Clin Nutr. 2003 May;57(5):681-92 - PubMed
  144. J Am Coll Cardiol. 2007 Jun 12;49(23):2231-7 - PubMed
  145. Biochem Biophys Res Commun. 1983 Aug 30;115(1):281-6 - PubMed
  146. Mol Nutr Food Res. 2015 May;59(5):1000-3 - PubMed
  147. N Engl J Med. 2015 Jun 18;372(25):2387-97 - PubMed
  148. J Lipid Res. 2000 May;41(5):697-705 - PubMed
  149. Am J Cardiol. 2012 Aug 1;110(3):356-63 - PubMed
  150. J Public Health (Oxf). 2011 Jun;33(2):160-9 - PubMed
  151. Clin Chim Acta. 1995 Mar 31;235(2):207-19 - PubMed
  152. Ann Nutr Metab. 1995;39(5):291-5 - PubMed
  153. Br J Pharmacol. 2009 Sep;158(2):442-50 - PubMed
  154. Food Chem. 2015 Jun 15;177:165-73 - PubMed
  155. Free Radic Res. 2005 Nov;39(11):1241-8 - PubMed
  156. J Steroid Biochem Mol Biol. 1992 Mar;41(3-8):615-9 - PubMed
  157. Adv Nutr. 2013 Nov 06;4(6):587-601 - PubMed
  158. J Clin Endocrinol Metab. 2012 Sep;97(9):3326-32 - PubMed
  159. Diabetologia. 2000 Aug;43(8):1012-9 - PubMed
  160. J Acad Nutr Diet. 2015 Mar;115(3):369-77 - PubMed
  161. J Biol Chem. 1998 Aug 21;273(34):21875-82 - PubMed
  162. Endocr Res. 1990;16(2):139-50 - PubMed
  163. Diabet Med. 2010 Apr;27(4):391-7 - PubMed
  164. Clin Biochem. 2009 Sep;42(13-14):1331-46 - PubMed
  165. Acta Pharmacol Sin. 2003 Nov;24(11):1167-71 - PubMed
  166. Am J Clin Nutr. 2000 Oct;72(4):922-8 - PubMed
  167. Brain Res. 1983 May 23;268(1):181-4 - PubMed
  168. J Nutr. 2015 Jan;145(1):159S-163S - PubMed
  169. J Nutr. 2009 Aug;139(8):1510-6 - PubMed
  170. FASEB J. 2002 Feb;16(2):258-60 - PubMed
  171. J Nutr Biochem. 2014 Mar;25(3):289-94 - PubMed
  172. Lancet. 1993 Oct 23;342(8878):1007-11 - PubMed
  173. J Nutr Metab. 2010;2010:null - PubMed
  174. Ann N Y Acad Sci. 1989;553:232-51 - PubMed
  175. J Nutr. 2014 Jun;144(6):830-7 - PubMed
  176. Maturitas. 2009 Aug 20;63(4):297-301 - PubMed
  177. Nutr Neurosci. 2001;4(6):469-74 - PubMed

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