Display options
Cite
Giridharan VV, Thandavarayan RA, Konishi T. Antioxidant Formulae, Shengmai San, and LingGuiZhuGanTang, Prevent MPTP Induced Brain Dysfunction and Oxidative Damage in Mice. Evid Based Complement Alternat Med. 2015;2015:584018doi: 10.1155/2015/584018.
Giridharan, V. V., Thandavarayan, R. A., & Konishi, T. (2015). Antioxidant Formulae, Shengmai San, and LingGuiZhuGanTang, Prevent MPTP Induced Brain Dysfunction and Oxidative Damage in Mice. Evidence-based complementary and alternative medicine : eCAM, 2015584018. https://doi.org/10.1155/2015/584018
Giridharan, Vijayasree Vayalanellore, et al. "Antioxidant Formulae, Shengmai San, and LingGuiZhuGanTang, Prevent MPTP Induced Brain Dysfunction and Oxidative Damage in Mice." Evidence-based complementary and alternative medicine : eCAM vol. 2015 (2015): 584018. doi: https://doi.org/10.1155/2015/584018
Giridharan VV, Thandavarayan RA, Konishi T. Antioxidant Formulae, Shengmai San, and LingGuiZhuGanTang, Prevent MPTP Induced Brain Dysfunction and Oxidative Damage in Mice. Evid Based Complement Alternat Med. 2015;2015:584018. doi: 10.1155/2015/584018. Epub 2015 Nov 05. PMID: 26612995; PMCID: PMC4647033.
Copy Download .nbib Format: NLM
Share it on

Evid Based Complement Alternat Med. 2015;2015:584018. doi: 10.1155/2015/584018. Epub 2015 Nov 05.

Antioxidant Formulae, Shengmai San, and LingGuiZhuGanTang, Prevent MPTP Induced Brain Dysfunction and Oxidative Damage in Mice.

Evidence-based complementary and alternative medicine : eCAM

Vijayasree Vayalanellore Giridharan, Rajarajan Amirthalingam Thandavarayan, Tetsuya Konishi

Affiliations

  1. J.K.K. Nattraja College of Pharmacy, Komarapalayam, Tamil Nadu 638 183, India ; Niigata University of Pharmacy & Applied Life Sciences, Niigata 956 8603, Japan.
  2. Niigata University of Pharmacy & Applied Life Sciences, Niigata 956 8603, Japan ; Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX 77030, USA.
  3. Niigata University of Pharmacy & Applied Life Sciences, Niigata 956 8603, Japan ; Changchun University of Chinese Medicine, Bosuo Road No. 1035, Jingyue Economic Development District, Changchun 130117, China.

PMID: 26612995 PMCID: PMC4647033 DOI: 10.1155/2015/584018

Abstract

The present study was designed to evaluate the preventive effect of antioxidative traditional oriental medicine formulae, Shengmai San (SMS) and LingGuiZhuGanTang (LGZGT), against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (i.p 30 mg·kg(-1) for 5 consecutive days) induced neurotoxicity. In in vitro antioxidant assays measured with Trolox and butyl hydroxyl toluene as reference antioxidant revealed that SMS has higher scavenging potential against hydroxyl radical than superoxide anion radical, but LGZGT was the reverse. The neuroprotective effect of SMS and LGZGT against MPTP was evaluated in mice by behavioral, biochemical, and immunohistochemical studies. In the behavioral study, both SMS and LGZGT significantly reversed the locomotive impairment induced by MPTP. Simultaneously, both formulae significantly prevented the MPTP induced dopaminergic neuron loss assessed by tyrosine hydroxylase in the midbrain. Both SMS and LGZGT significantly attenuated the elevated lipid peroxidation and protein carbonyls levels by MPTP. The DNA damage induced by MPTP was also prevented by both formulae. Although a little difference in the protective functions was observed between the two formulae, such as in DNA damage and behavioral studies, the results indicate that both SMS and LGZGT with antioxidant property act as a good candidate applicable for the antioxidant based complementary therapies of neurodegenerative diseases.

References

  1. Int J Hyg Environ Health. 2001 Oct;204(1):61-6 - PubMed
  2. Mutat Res. 2001 Feb 20;490(2):187-97 - PubMed
  3. Afr J Tradit Complement Altern Med. 2014 Apr 03;11(3):38-45 - PubMed
  4. J Med Food. 2011 Jun;14(6):601-9 - PubMed
  5. Proc Natl Acad Sci U S A. 1990 Jan;87(2):682-5 - PubMed
  6. Brain Pathol. 1999 Jan;9(1):165-86 - PubMed
  7. Biol Pharm Bull. 2014;37(8):1301-7 - PubMed
  8. Int J Neuropsychopharmacol. 2001 Dec;4(4):361-70 - PubMed
  9. Free Radic Res. 2011 Aug;45(8):950-8 - PubMed
  10. Biochem Mol Biol Int. 1998 Sep;46(1):137-45 - PubMed
  11. Science. 1984 Jun 29;224(4656):1451-3 - PubMed
  12. J Pharmacol Sci. 2005 May;98(1):1-7 - PubMed
  13. Zhongguo Zhong Yao Za Zhi. 2002 Oct;27(10 ):760-2 - PubMed
  14. Neurochem Res. 2009 Apr;34(4):711-6 - PubMed
  15. Neurol Sci. 2001 Feb;22(1):83-4 - PubMed
  16. Pharm Biol. 2015;53(11):1591-601 - PubMed
  17. Biochim Biophys Acta. 1997 Nov 28;1362(1):77-86 - PubMed
  18. Behav Brain Res. 2001 Nov 1;125(1-2):109-25 - PubMed
  19. Free Radic Biol Med. 1997;23(3):361-6 - PubMed
  20. Trends Pharmacol Sci. 2003 Aug;24(8):395-401 - PubMed
  21. Biol Pharm Bull. 2002 Jul;25(7):898-903 - PubMed
  22. J Tradit Chin Med. 2011 Sep;31(3):209-19 - PubMed
  23. J Agric Food Chem. 2008 Aug 27;56(16):6910-3 - PubMed
  24. Neurochem Res. 2009 Apr;34(4):630-8 - PubMed
  25. Prog Neurobiol. 1996 Jan;48(1):1-19 - PubMed
  26. Free Radic Biol Med. 2003 Dec 15;35(12):1632-44 - PubMed
  27. Free Radic Biol Med. 1998 Jan 1;24(1):76-84 - PubMed
  28. J Neurochem. 1997 Sep;69(3):1326-9 - PubMed
  29. Neurodegeneration. 1996 Dec;5(4):299-312 - PubMed
  30. J Neurochem. 1998 Jan;70(1):268-75 - PubMed
  31. Arch Biochem Biophys. 1980 Mar;200(1):1-16 - PubMed
  32. J Agric Food Chem. 2010 Nov 10;58(21):11510-6 - PubMed
  33. Mov Disord. 2005;20 Suppl 11:S11-6 - PubMed
  34. Neuropsychiatr Dis Treat. 2008 Aug;4(4):743-57 - PubMed
  35. J Clin Pharmacol. 2000 May;40(5):445-50 - PubMed
  36. Biol Pharm Bull. 2006 Jul;29(7):1401-3 - PubMed
  37. Prog Neuropsychopharmacol Biol Psychiatry. 2004 Aug;28(5):771-99 - PubMed
  38. Free Radic Res. 2012 Jan;46(1):50-60 - PubMed
  39. Nat Protoc. 2007;2(1):141-51 - PubMed
  40. Evid Based Complement Alternat Med. 2007 Jun;4(2):195-202 - PubMed
  41. Free Radic Biol Med. 2010 Nov 15;49(9):1422-31 - PubMed
  42. Free Radic Biol Med. 2008 Mar 1;44(5):907-17 - PubMed
  43. Res Commun Chem Pathol Pharmacol. 1985 Dec;50(3):435-41 - PubMed
  44. Curr Med Chem. 2001 Jun;8(7):809-14 - PubMed
  45. Neuron. 2003 Sep 11;39(6):889-909 - PubMed

Publication Types