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Stine JG, Shah PM, Cornella SL, et al. Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis. World J Hepatol. 2015;7(27):2774-80doi: 10.4254/wjh.v7.i27.2774.
Stine, J. G., Shah, P. M., Cornella, S. L., Rudnick, S. R., Ghabril, M. S., Stukenborg, G. J., & Northup, P. G. (2015). Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis. World journal of hepatology, 7(27), 2774-80. https://doi.org/10.4254/wjh.v7.i27.2774
Stine, Jonathan G, et al. "Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis." World journal of hepatology vol. 7,27 (2015): 2774-80. doi: https://doi.org/10.4254/wjh.v7.i27.2774
Stine JG, Shah PM, Cornella SL, Rudnick SR, Ghabril MS, Stukenborg GJ, Northup PG. Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis. World J Hepatol. 2015 Nov 28;7(27):2774-80. doi: 10.4254/wjh.v7.i27.2774. PMID: 26644821; PMCID: PMC4663397.
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World J Hepatol. 2015 Nov 28;7(27):2774-80. doi: 10.4254/wjh.v7.i27.2774.

Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis.

World journal of hepatology

Jonathan G Stine, Puja M Shah, Scott L Cornella, Sean R Rudnick, Marwan S Ghabril, George J Stukenborg, Patrick G Northup

Affiliations

  1. Jonathan G Stine, Sean R Rudnick, Patrick G Northup, Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA 22908, United States.

PMID: 26644821 PMCID: PMC4663397 DOI: 10.4254/wjh.v7.i27.2774

Abstract

AIM: To determine the clinical impact of portal vein thrombosis in terms of both mortality and hepatic decompensations (variceal hemorrhage, ascites, portosystemic encephalopathy) in adult patients with cirrhosis.

METHODS: We identified original articles reported through February 2015 in MEDLINE, Scopus, Science Citation Index, AMED, the Cochrane Library, and relevant examples available in the grey literature. Two independent reviewers screened all citations for inclusion criteria and extracted summary data. Random effects odds ratios were calculated to obtain aggregate estimates of effect size across included studies, with 95%CI.

RESULTS: A total of 226 citations were identified and reviewed, and 3 studies with 2436 participants were included in the meta-analysis of summary effect. Patients with portal vein thrombosis had an increased risk of mortality (OR = 1.62, 95%CI: 1.11-2.36, P = 0.01). Portal vein thrombosis was associated with an increased risk of ascites (OR = 2.52, 95%CI: 1.63-3.89, P < 0.001). There was insufficient data available to determine the pooled effect on other markers of decompensation including gastroesophageal variceal bleeding or hepatic encephalopathy.

CONCLUSION: Portal vein thrombosis appears to increase mortality and ascites, however, the relatively small number of included studies limits more generalizable conclusions. More trials with a direct comparison group are needed.

Keywords: Ascites; Coagulopathy; Hepatic encephalopathy; Hepatology; Liver; Portal hypertension

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