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Abutorabi R, Baradaran A, Sadat Mostafavi F, et al. Evaluation of Tumor Necrosis Factor Alpha Polymorphism Frequencies in Endometriosis. Int J Fertil Steril. 2015;9(3):329-37doi: 10.22074/ijfs.2015.4548.
Abutorabi, R., Baradaran, A., Sadat Mostafavi, F., Zarrin, Y., & Mardanian, F. (2015). Evaluation of Tumor Necrosis Factor Alpha Polymorphism Frequencies in Endometriosis. International journal of fertility & sterility, 9(3), 329-37. https://doi.org/10.22074/ijfs.2015.4548
Abutorabi, Roshanak, et al. "Evaluation of Tumor Necrosis Factor Alpha Polymorphism Frequencies in Endometriosis." International journal of fertility & sterility vol. 9,3 (2015): 329-37. doi: https://doi.org/10.22074/ijfs.2015.4548
Abutorabi R, Baradaran A, Sadat Mostafavi F, Zarrin Y, Mardanian F. Evaluation of Tumor Necrosis Factor Alpha Polymorphism Frequencies in Endometriosis. Int J Fertil Steril. 2015 Oct-Dec;9(3):329-37. doi: 10.22074/ijfs.2015.4548. Epub 2015 Oct 31. PMID: 26644856; PMCID: PMC4671386.
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Int J Fertil Steril. 2015 Oct-Dec;9(3):329-37. doi: 10.22074/ijfs.2015.4548. Epub 2015 Oct 31.

Evaluation of Tumor Necrosis Factor Alpha Polymorphism Frequencies in Endometriosis.

International journal of fertility & sterility

Roshanak Abutorabi, Azar Baradaran, Fatemeh Sadat Mostafavi, Yasaman Zarrin, Farahnaz Mardanian

Affiliations

  1. Infertility Laboratory, Beheshti Hospital, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  2. Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  3. Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  4. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  5. Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

PMID: 26644856 PMCID: PMC4671386 DOI: 10.22074/ijfs.2015.4548

Abstract

BACKGROUND: The pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-α), is a pathogenic element for a number of disorders. Previous studies have reported that the -1031 T/C and -238 G/A polymorphisms in the promoter region of the TNF-α gene are important factors in reproductive-related disorders. One of the most common gynecological diseases of women during the reproductive years is endometriosis. This study aims to assess an association between the -1031 T/C, -238 G/A and -308 G/A polymorphisms of the TNF-α gene promoter region to endometriosis.

MATERIALS AND METHODS: In this case-control study, we enrolled 65 endometriosis patients and 65 matched healthy control women by simple sampling. Polymerase chain reaction (PCR) analysis was used to analyze -1031 T/C, -238 G/A and -308 G/A polymorphisms in the TNF-α gene promoter region. Statistical analysis was performed using the chi-square test. P values less than 0.05 were considered statistically significant.

RESULTS: We found a strong association between the -1031 T/C polymorphism in the promoter region of the TNF-α gene with endometriosis (P=0.001). There were no significant associations between the -238 G/A (P=0.243) and -308 G/A (P=1) polymorphisms with endometriosis and again endometriosis stages have no association with these polymorphisms.

CONCLUSION: The -1031 T/C polymorphism and CC genotype can be used as a relevant marker to identify women at risk of developing endometriosis.

Keywords: Endometriosis; Polymorphism; Tumor Necrosis Factor

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