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Katner SN, McBRIDE WJ, Lumeng L, et al. Involvement of CNS cholinergic systems in alcohol drinking of P rats. Addict Biol. 1997;2(2):215-23doi: 10.1080/13556219772769.
Katner, S. N., McBRIDE, W. J., Lumeng, L., Li, T. K., & Murphy, J. M. (1997). Involvement of CNS cholinergic systems in alcohol drinking of P rats. Addiction biology, 2(2), 215-23. https://doi.org/10.1080/13556219772769
Katner, S N, et al. "Involvement of CNS cholinergic systems in alcohol drinking of P rats." Addiction biology vol. 2,2 (1997): 215-23. doi: https://doi.org/10.1080/13556219772769
Katner SN, McBRIDE WJ, Lumeng L, Li TK, Murphy JM. Involvement of CNS cholinergic systems in alcohol drinking of P rats. Addict Biol. 1997 Apr;2(2):215-23. doi: 10.1080/13556219772769. PMID: 26735639.
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Addict Biol. 1997 Apr;2(2):215-23. doi: 10.1080/13556219772769.

Involvement of CNS cholinergic systems in alcohol drinking of P rats.

Addiction biology

S N Katner, W J McBRIDE, L Lumeng, T K Li, J M Murphy

Affiliations

  1. Program in Medical Neurobiology, Institute of Psychiatric Research, Departments of Psychiatry, Medicine and Biochemistry, Indiana University School of Medicine and VA Medical Center & Department of Psychology, Purdue School of Science, Indiana University-Purdue University, Indianapolis, USA.

PMID: 26735639 DOI: 10.1080/13556219772769

Abstract

Experiments were undertaken to determine if CNS muscarinic- and nicotinic-cholinergic receptors are involved in regulating alcohol drinking of rats from the selectively-bred alcohol-preferring P line. Intracerebroventricular (i.c.v.) drug infusions were administered into the lateral ventricle of female P rats 15 minutes before ethanol access. The muscarinic antagonists pirenzepine and scopolamine were tested on limited access (4 hours/day) to a 10% (v/v) ethanol solution. Food and water were available ad libitum. Nicotine and the nicotinic antagonist mecamylamine were tested on limited access (4 hours/day) to 10% (v/v) ethanol and 0.0125% saccharin solutions. Food was available ad libitum and water was available during the remaining 20 hours. The baseline ethanol intakes ranged between an average of 3.0 ± 0.3 g/kg/4 hours and 3.4 ± 0.3 g/kg/4 hours. Administration of 40-100 m g pirenzepine (M1-selective antagonist) had no effect on ethanol, food or water consumption. However, 20-80 m g scopolamine, a non-selective muscarinic antagonist, dosedependently decreased ethanol intake as much as 60% (p < 0.05) without altering food or water consumption. The nicotinic antagonist mecamylamine (20-120 m g) did not alter ethanol intake, but nicotine (40-80 m g) dose-dependently decreased ethanol drinking as much as 60% within the first 30 minutes (p < 0.05) without an effect on saccharin intake. The results suggest that: (a), muscarinic receptors, with the possible exception of the M1 subtype, are involved in regulating alcohol drinking and (b), activation of nicotinic receptors can reduce alcohol drinking of the P line of rats.

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