Display options
Cite
Santhoshkumar R, Mannathan S, Cheng CH. Ligand-Controlled Divergent C-H Functionalization of Aldehydes with Enynes by Cobalt Catalysts. J Am Chem Soc. 2015;137(51):16116-20doi: 10.1021/jacs.5b10447.
Santhoshkumar, R., Mannathan, S., & Cheng, C. H. (2015). Ligand-Controlled Divergent C-H Functionalization of Aldehydes with Enynes by Cobalt Catalysts. Journal of the American Chemical Society, 137(51), 16116-20. https://doi.org/10.1021/jacs.5b10447
Santhoshkumar, Rajagopal, et al. "Ligand-Controlled Divergent C-H Functionalization of Aldehydes with Enynes by Cobalt Catalysts." Journal of the American Chemical Society vol. 137,51 (2015): 16116-20. doi: https://doi.org/10.1021/jacs.5b10447
Santhoshkumar R, Mannathan S, Cheng CH. Ligand-Controlled Divergent C-H Functionalization of Aldehydes with Enynes by Cobalt Catalysts. J Am Chem Soc. 2015 Dec 30;137(51):16116-20. doi: 10.1021/jacs.5b10447. Epub 2015 Dec 16. PMID: 26645104.
Copy Download .nbib Format: NLM
Share it on

J Am Chem Soc. 2015 Dec 30;137(51):16116-20. doi: 10.1021/jacs.5b10447. Epub 2015 Dec 16.

Ligand-Controlled Divergent C-H Functionalization of Aldehydes with Enynes by Cobalt Catalysts.

Journal of the American Chemical Society

Rajagopal Santhoshkumar, Subramaniyan Mannathan, Chien-Hong Cheng

Affiliations

  1. Department of Chemistry, National Tsing Hua University , Hsinchu 30013, Taiwan.

PMID: 26645104 DOI: 10.1021/jacs.5b10447

Abstract

We describe a highly step and atom economical cobalt-catalyzed cyclization of 1,6-enynes with aldehydes to synthesize functionalized pyrrolidines and dihydrofurans with high chemo- and stereoselectivity. The catalytic reaction plausibly proceeds via the cobaltacycle intermediate generated from the reaction of enyne substrate with cobalt catalyst, followed by switchable C-H functionalization of weakly coordinating aldehydes depending on the electronic nature of the ligand.

Publication Types