Display options
Cite
Carlier A, Lammens J, Van Oosterwyck H, et al. Computational modeling of bone fracture non-unions: four clinically relevant case studies. In Silico Cell Tissue Sci. 2015;2:1doi: 10.1186/s40482-015-0004-x.
Carlier, A., Lammens, J., Van Oosterwyck, H., & Geris, L. (2015). Computational modeling of bone fracture non-unions: four clinically relevant case studies. In silico cell and tissue science, 21. https://doi.org/10.1186/s40482-015-0004-x
Carlier, Aurélie, et al. "Computational modeling of bone fracture non-unions: four clinically relevant case studies." In silico cell and tissue science vol. 2 (2015): 1. doi: https://doi.org/10.1186/s40482-015-0004-x
Carlier A, Lammens J, Van Oosterwyck H, Geris L. Computational modeling of bone fracture non-unions: four clinically relevant case studies. In Silico Cell Tissue Sci. 2015 Dec 18;2:1. doi: 10.1186/s40482-015-0004-x. eCollection 2015. PMID: 26709368; PMCID: PMC4684906.
Copy Download .nbib Format: NLM
Share it on

In Silico Cell Tissue Sci. 2015 Dec 18;2:1. doi: 10.1186/s40482-015-0004-x. eCollection 2015.

Computational modeling of bone fracture non-unions: four clinically relevant case studies.

In silico cell and tissue science

Aurélie Carlier, Johan Lammens, Hans Van Oosterwyck, Liesbet Geris

Affiliations

  1. Biomechanics Section, KU Leuven, Celestijnenlaan 300 C, PB 2419, 3000 Leuven, Belgium ; Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, O&N 1, Herestraat 49, PB 813, 3000 Leuven, Belgium.
  2. Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, O&N 1, Herestraat 49, PB 813, 3000 Leuven, Belgium ; Department of Orthopaedics, University Hospitals of KU Leuven, KU Leuven, Weligerveld 1-blok 1, 3212 Pellenberg, Belgium.
  3. Biomechanics Section, KU Leuven, Celestijnenlaan 300 C, PB 2419, 3000 Leuven, Belgium ; Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, O&N 1, Herestraat 49, PB 813, 3000 Leuven, Belgium ; Biomechanics Research Unit, Department of Aerospace and Mechanical Engineering, University of Liege, Chemin des Chevreuils 1-BAT 52/3, 4000 Liege 1, Belgium.

PMID: 26709368 PMCID: PMC4684906 DOI: 10.1186/s40482-015-0004-x

Abstract

The human skeleton has a remarkable regeneration capacity. Nevertheless, 5-10 % of the bone fractures fails to heal and develops into a non-union which is a challenging orthopedic complication requiring complex and expensive treatment. This review paper will discuss four different computational models, each capturing a particular clinical case of non-union: non-union induced by reaming of the marrow canal and periosteal stripping, non-union due to a large interfragmentary gap, non-union due to a genetic disorder [i.e. NF1 related congenital pseudoarthrosis of the tibia (CPT)] and non-union due to mechanical overload. Together, the four computational models are able to capture the etiology of a wide range of fracture non-union types and design novel treatment strategies thereof. Further research is required to corroborate the computational models in both animal and human settings and translate them from bench to bed side.

Keywords: Computational model; Fracture healing; Non-union

References

  1. Contemp Orthop. 1995 Jun;30(6):489-93 - PubMed
  2. Clin Orthop Relat Res. 2000 Feb;(371):10-27 - PubMed
  3. J Bone Joint Surg Br. 2000 Sep;82(7):977-83 - PubMed
  4. J Orthop Trauma. 2001 Jan;15(1):47-53 - PubMed
  5. J Bone Joint Surg Br. 2003 May;85(4):604-10 - PubMed
  6. J Bone Joint Surg Am. 1956 Apr;38-A(2):270-82 - PubMed
  7. J Trauma. 2004 Feb;56(2):368-78 - PubMed
  8. Clin Orthop Relat Res. 2004 Feb;(419):4-12 - PubMed
  9. J Theor Biol. 2005 Jul 7;235(1):105-19 - PubMed
  10. Clin Orthop Relat Res. 1992 Jul;(280):136-42 - PubMed
  11. J Biomech. 2005 Dec;38(12):2440-50 - PubMed
  12. Injury. 2006 Aug;37(8):681-90 - PubMed
  13. J Bone Joint Surg Br. 2006 Jan;88(1):116-8 - PubMed
  14. J Bone Joint Surg Am. 2006 Mar;88(3):627-33 - PubMed
  15. J Pediatr Orthop B. 2006 May;15(3):220-1 - PubMed
  16. Clin Biomech (Bristol, Avon). 2007 Dec;22(10):1049-62 - PubMed
  17. Injury. 2007 May;38 Suppl 2:S1-2 - PubMed
  18. Acta Orthop Belg. 2007 Oct;73(5):630-4 - PubMed
  19. Bone. 2008 Apr;42(4):616-22 - PubMed
  20. J Bone Miner Res. 2009 May;24(5):860-70 - PubMed
  21. Injury. 2009 Jun;40(6):663-8 - PubMed
  22. J Orthop Trauma. 2009 May-Jun;23(5 Suppl):S31-8 - PubMed
  23. J Bone Joint Surg Br. 2009 Aug;91(8):987-96 - PubMed
  24. J Biomech. 2009 Nov 13;42(15):2575-83 - PubMed
  25. Injury. 2009 Oct;40(10):1021-2 - PubMed
  26. Indian J Orthop. 2008 Oct;42(4):377-86 - PubMed
  27. Indian J Orthop. 2009 Apr;43(2):109-10 - PubMed
  28. Orthop Clin North Am. 2010 Jan;41(1):27-37; table of contents - PubMed
  29. J Orthop Trauma. 2010 Mar;24 Suppl 1:S36-40 - PubMed
  30. Biomech Model Mechanobiol. 2010 Dec;9(6):713-24 - PubMed
  31. Philos Trans A Math Phys Eng Sci. 2010 Jun 13;368(1920):2683-706 - PubMed
  32. Clin Biomech (Bristol, Avon). 2010 Jul;25(6):606-12 - PubMed
  33. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13614-9 - PubMed
  34. Acta Biotheor. 2010 Dec;58(4):355-67 - PubMed
  35. PLoS Comput Biol. 2010 Sep 02;6(9):e1000915 - PubMed
  36. Injury. 2010 Nov;41(11):1191-5 - PubMed
  37. Comput Methods Biomech Biomed Engin. 2011;14(1):79-93 - PubMed
  38. Bone. 2011 Apr 1;48(4):918-26 - PubMed
  39. Tissue Eng Part C Methods. 2011 May;17(5):597-606 - PubMed
  40. J Orthop Res. 2011 Oct;29(10):1496-503 - PubMed
  41. Injury. 2011 Jun;42(6):591-8 - PubMed
  42. BMC Med. 2011 May 31;9:66 - PubMed
  43. Int Orthop. 2011 Sep;35(9):1271-80 - PubMed
  44. Bone. 2011 Oct;49(4):591-9 - PubMed
  45. Orthop Traumatol Surg Res. 2011 Nov;97(7):750-61 - PubMed
  46. Bone. 2012 Jan;50(1):378-89 - PubMed
  47. Nat Rev Rheumatol. 2012 Jan 31;8(3):133-43 - PubMed
  48. Injury. 2012 Jul;43(7):1090-5 - PubMed
  49. J Am Acad Orthop Surg. 2012 May;20(5):273-82 - PubMed
  50. J Theor Biol. 2012 Aug 21;307:42-52 - PubMed
  51. J Surg Res. 2013 May 1;181(1):e7-e14 - PubMed
  52. Acta Biomater. 2012 Nov;8(11):3876-87 - PubMed
  53. PLoS One. 2012;7(7):e40737 - PubMed
  54. Tissue Eng Part C Methods. 2013 Apr;19(4):271-80 - PubMed
  55. Acta Orthop Belg. 2012 Oct;78(5):569-73 - PubMed
  56. Curr Top Microbiol Immunol. 2013;367:113-32 - PubMed
  57. Lancet. 2012 Dec 15;380(9859):2197-223 - PubMed
  58. Organogenesis. 2012 Oct-Dec;8(4):114-24 - PubMed
  59. Injury. 2013 Jan;44 Suppl 1:S43-5 - PubMed
  60. Bone. 2013 Jul;55(1):241-7 - PubMed
  61. BMC Musculoskelet Disord. 2013 Mar 22;14:103 - PubMed
  62. Bonekey Rep. 2012 Nov 14;1:221 - PubMed
  63. J Child Orthop. 2013 Mar;7(2):157-66 - PubMed
  64. J Bone Joint Surg Am. 2014 Apr 16;96(8):674-81 - PubMed
  65. PLoS Comput Biol. 2014 Jun 26;10(6):e1003604 - PubMed
  66. Int Orthop. 2014 Sep;38(9):1771-8 - PubMed
  67. Calcif Tissue Int. 1989 Nov;45(5):292-7 - PubMed
  68. PLoS Comput Biol. 2014 Nov 06;10(11):e1003888 - PubMed
  69. Wiley Interdiscip Rev Syst Biol Med. 2015 Jul-Aug;7(4):183-94 - PubMed
  70. J Bone Joint Surg Am. 1989 Aug;71(7):1004-19 - PubMed
  71. Sci Rep. 2017 Jun 30;7:46384 - PubMed
  72. Clin Orthop Relat Res. 1995 Jun;(315):34-47 - PubMed
  73. J Orthop Trauma. 1995;9(5):392-400 - PubMed
  74. J Bone Joint Surg Am. 1997 Aug;79(8):1243-58 - PubMed
  75. Clin Orthop Relat Res. 1998 Oct;(355 Suppl):S7-21 - PubMed
  76. Clin Orthop Relat Res. 1998 Oct;(355 Suppl):S22-30 - PubMed

Publication Types