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Sim EH, Lee HW, Choi HJ, et al. The Association of Serum Cystatin C with Glycosylated Hemoglobin in Korean Adults. Diabetes Metab J. 2016;40(1):62-9doi: 10.4093/dmj.2016.40.1.62.
Sim, E. H., Lee, H. W., Choi, H. J., Jeong, D. W., Son, S. M., & Kang, Y. H. (2016). The Association of Serum Cystatin C with Glycosylated Hemoglobin in Korean Adults. Diabetes & metabolism journal, 40(1), 62-9. https://doi.org/10.4093/dmj.2016.40.1.62
Sim, Eun Hee, et al. "The Association of Serum Cystatin C with Glycosylated Hemoglobin in Korean Adults." Diabetes & metabolism journal vol. 40,1 (2016): 62-9. doi: https://doi.org/10.4093/dmj.2016.40.1.62
Sim EH, Lee HW, Choi HJ, Jeong DW, Son SM, Kang YH. The Association of Serum Cystatin C with Glycosylated Hemoglobin in Korean Adults. Diabetes Metab J. 2016 Feb;40(1):62-9. doi: 10.4093/dmj.2016.40.1.62. PMID: 26616596; PMCID: PMC4768052.
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Diabetes Metab J. 2016 Feb;40(1):62-9. doi: 10.4093/dmj.2016.40.1.62.

The Association of Serum Cystatin C with Glycosylated Hemoglobin in Korean Adults.

Diabetes & metabolism journal

Eun Hee Sim, Hye Won Lee, Hyun Ju Choi, Dong Wook Jeong, Seok Man Son, Yang Ho Kang

Affiliations

  1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
  2. Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
  3. Department of Family Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
  4. Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea. [email protected].

PMID: 26616596 PMCID: PMC4768052 DOI: 10.4093/dmj.2016.40.1.62

Abstract

BACKGROUND: Cystatin C has been known to be associated not only with early renal impairment but also with the incidence of diabetic conditions (prediabetes plus diabetes). However, it is not clear whether cystatin C levels are associated with the prevalence of diabetic conditions in Asian populations. We evaluated this association using glycosylated hemoglobin (HbA1c) levels as the definition of diabetes in Korean adults.

METHODS: We analyzed data from 1,559 Korean adults (937 men and 622 women) with available serum cystatin C and HbA1c values.

RESULTS: The serum cystatin C levels in subjects with prediabetes and diabetes were significantly increased (0.91±0.14 mg/L in prediabetes and 0.91±0.17 mg/L in diabetes vs. 0.88±0.13 mg/L in patients with normal glucose levels, P=0.001). At increasing cystatin C levels, the prevalence of subjects with prediabetes (30.2% vs. 14.6%, P<0.001) and those with diabetes (10.6% vs. 8.0%, P<0.001) significantly increased in the group with the highest cystatin C levels. The group with the highest cystatin C levels had a significantly increased odds ratio (OR) for the presence of diabetic conditions compared to the group with the lowest values in total subjects (OR, 2.35; 95% confidence interval [CI], 1.54 to 3.58; P<0.001) and in women (OR, 4.13; 95% CI, 1.97 to 8.65; P<0.001), though there was no significant increase after adjusting for multiple variables.

CONCLUSIONS: Higher levels of serum cystatin C are associated with an increased prevalence of diabetic conditions in Korean adults. Our findings may extend the positive association of cystatin C with diabetes incidence to an Asian population.

Keywords: Cystatin C; Diabetes mellitus; Hemoglobin A, glycosylated; Prediabetic state

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