Hosp Chron. 2015;10(2):91-98.
Electrophysiological Neuroimaging using sLORETA Comparing 22 Age Matched Male and Female Schizophrenia Patients.
Hospital chronicles = Nosokomeiaka chronika
Andy R Eugene, Jolanta Masiak, Jacek Kapica, Marek Masiak, Richard M Weinshilboum
Affiliations
Affiliations
- Department of Molecular Pharmacology and Experimental Therapeutics, Division of Clinical Pharmacology, Gonda 19, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.
- Department of Psychiatry, Medical University of Lublin, ul. Gluska 1 (SPSK Nr 1), Lublin 20-439, Poland.
- Department of Electrical Engineering and Measurement Systems, University of Life Sciences in Lublin, 13 Akademicka Street, Lublin 20-950, Poland.
PMID: 26617679
PMCID: PMC4662405
Abstract
INTRODUCTION: The purpose of this electrophysiological neuroimaging study was to provide a deeper mechanistic understanding of both olanzapine and risperidone pharmacodynamics relative to gender. In doing so, we age-matched 22 men and women and evaluated their resting-state EEG recordings and later used standard low resolution brain Electrotomography to visualize the differences in brain activity amongst the two patient groups.
METHODS: In this investigation, electroencephalogram (EEG) data were analyzed from male and female schizophrenia patients treated with either olanzapine or risperidone, both atypical antipsychotics, during their in-patient stay at the Department of Psychiatry. Twenty-two males and females were age-matched and EEG recordings were analyzed from 19 Ag/AgCl electrodes. Thirty-seconds of resting EEG were spectrally transformed in standardized low resolution electromagnetic tomography (sLORETA). 3D statistical non-paramentric maps for the sLORETA Global Field Power within each band were finally computed.
RESULTS: The results indicated that, relative to males patients, females schizophrenia patients had increased neuronal synchronization in delta frequency, slow-wave, EEG band located in the dorsolateral prefrontal cortex, within the middle frontal gyrus (t= -2.881, p < 0.03580). These findings suggest that females experience greater dopamine (D2) receptor and serotonin (5-HT2) receptor neuronal blockade relative to age-matched males. Further, our finding provided insight to the pharmacodynamics of second-generation antipsychotics olanzapine and risperidone.
CONCLUSION: When compared to male patients, female patients, suffering from schizophrenia, have D2 and 5-HT2 receptors that are blocked more readily than age-matched male schizophrenia patients. Clinically, this may translate into a quicker time to treatment-response in females as compared to male patients.
Keywords: EEG; dopamine; pharmacodynamics; sLORETA; schizophrenia; serotonin
References
- Br J Clin Pharmacol. 2001 Apr;51(4):317-24 - PubMed
- Biol Psychiatry. 1997 May 15;41(10):1020-7 - PubMed
- Clin Pharmacol Ther. 2001 Mar;69(3):89-95 - PubMed
- Am J Psychiatry. 2004 Aug;161(8):1324-33 - PubMed
- Int J Clin Pharmacol Ther Toxicol. 1980;18(8):362-6 - PubMed
- J Cereb Blood Flow Metab. 1996 Jan;16(1):7-22 - PubMed
- J Psychiatr Res. 2009 Feb;43(5):497-502 - PubMed
- Neuroimage. 2007 Feb 15;34(4):1600-11 - PubMed
- Lancet Neurol. 2011 Sep;10(9):829-43 - PubMed
- Nat Rev Neurosci. 2002 Mar;3(3):243-9 - PubMed
- Neuropsychobiology. 2007;55(3-4):132-42 - PubMed
- Clin Neurophysiol. 2002 May;113(5):702-12 - PubMed
- Int J Psychophysiol. 1994 Oct;18(1):49-65 - PubMed
- Am J Psychiatry. 1999 Feb;156(2):286-93 - PubMed
- Psychophysiology. 1994 Jan;31(1):37-43 - PubMed
- Pharmakopsychiatr Neuropsychopharmakol. 1979 Mar;12(2):237-45 - PubMed
- Harv Rev Psychiatry. 1994 Nov-Dec;2(4):204-13 - PubMed
- Clin Neurophysiol. 2001 Apr;112(4):713-9 - PubMed
- Biol Psychiatry. 1987 Aug;22(8):1021-4 - PubMed
- Electroencephalogr Clin Neurophysiol. 1993 Jan;86(1):1-6 - PubMed
- Biol Psychiatry. 2006 Jul 1;60(1):11-21 - PubMed
- JAMA Psychiatry. 2015 Jan;72(1):5-13 - PubMed
- Schizophr Res. 2001 Mar 30;48(2-3):207-17 - PubMed
- Am J Psychiatry. 1998 Jul;155(7):921-8 - PubMed
- Ann Neurol. 1990 Dec;28(6):811-7 - PubMed
- Biol Psychiatry. 1994 Dec 15;36(12):801-26 - PubMed
- Psychiatry Res. 1999 Jun 30;90(3):169-79 - PubMed
- Philos Trans R Soc Lond B Biol Sci. 2001 Aug 29;356(1412):1293-322 - PubMed
- Methods Find Exp Clin Pharmacol. 2002;24 Suppl D:5-12 - PubMed
- Arq Neuropsiquiatr. 2003 Sep;61(3B):712-7 - PubMed
- Neurosci Res. 2011 Aug;70(4):442-8 - PubMed
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