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Baghdadi J, Hemarajata P, Humphries R, et al. First Report of Ventriculoperitoneal Shunt Infection due to Cyberlindnera fabianii. Case Rep Infect Dis. 2015;2015:630816doi: 10.1155/2015/630816.
Baghdadi, J., Hemarajata, P., Humphries, R., & Kelesidis, T. (2015). First Report of Ventriculoperitoneal Shunt Infection due to Cyberlindnera fabianii. Case reports in infectious diseases, 2015630816. https://doi.org/10.1155/2015/630816
Baghdadi, Jonathan, et al. "First Report of Ventriculoperitoneal Shunt Infection due to Cyberlindnera fabianii." Case reports in infectious diseases vol. 2015 (2015): 630816. doi: https://doi.org/10.1155/2015/630816
Baghdadi J, Hemarajata P, Humphries R, Kelesidis T. First Report of Ventriculoperitoneal Shunt Infection due to Cyberlindnera fabianii. Case Rep Infect Dis. 2015;2015:630816. doi: 10.1155/2015/630816. Epub 2015 Nov 04. PMID: 26618013; PMCID: PMC4649088.
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Case Rep Infect Dis. 2015;2015:630816. doi: 10.1155/2015/630816. Epub 2015 Nov 04.

First Report of Ventriculoperitoneal Shunt Infection due to Cyberlindnera fabianii.

Case reports in infectious diseases

Jonathan Baghdadi, Peera Hemarajata, Romney Humphries, Theodoros Kelesidis

Affiliations

  1. Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
  2. Department of Pathology & Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

PMID: 26618013 PMCID: PMC4649088 DOI: 10.1155/2015/630816

Abstract

Fungal infections in the central nervous system (CNS) are associated with significant morbidity and death. Transient fungemia in immunocompetent patients without any other risk factors for fungemia has been suggested as a possible mechanism that may lead to serious fungal ventriculoperitoneal (VP) shunt infections, but evidence is lacking. The clinical spectrum, diagnosis, and optimal therapy of Cyberlindnera fabianii infections remain to be determined. We describe the first case of CNS infection due to C. fabianii that occurred in an immunocompetent adult with a VP shunt. Spontaneous translocation with yeast that is not part of the normal gastrointestinal flora in the setting of ingestion of multiple servings of a fermentation product was the likely source from which Cyberlindnera fabianii gained entrance into the VP shunt system, causing meningitis in this patient. The authors conclude that, in view of the high morbidity associated with yeast infection of the CNS, long-term antifungal therapy should be strongly considered in cases where the VP shunt cannot be completely removed. Transient fungemia may lead to invasive disease in an immunocompetent host with VP shunt, even in the absence of any other risk factors for fungemia and even after remote placement of the VP shunt.

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