J Pharm Bioallied Sci. 2015 Oct-Dec;7(4):289-92. doi: 10.4103/0975-7406.168028.
Antidiabetic activity of ethanolic extract of Cyperus rotundus rhizomes in streptozotocin-induced diabetic mice.
Journal of pharmacy & bioallied sciences
Pradeep Singh, Ratan L Khosa, Garima Mishra, Keshri K Jha
Affiliations
Affiliations
- Department of Pharmacognosy, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.
- Department of Pharmaceutical Sciences, Bharat Institute of Technology, Meerut, Uttar Pradesh, India.
PMID: 26681885
PMCID: PMC4678986 DOI: 10.4103/0975-7406.168028
Abstract
OBJECTIVE: In the present investigation, ethanolic extract of Cyperus rotundus (EECR) rhizomes was evaluated for antidiabetic activity in streptozotocin (STZ)-induced diabetic swiss mice.
MATERIALS AND METHODS: After administration of EECR extract for 3 weeks, the body weight, blood glucose, biomarker enzymes (serum glutamic pyruvic transaminase [SGPT] and serum glutamic oxaloacetic transaminase [SGOT]), and plasma lipid levels were measured in STZ-induced diabetic mice.
RESULTS: The ethanolic extract at dose levels of 250 and 500 mg/kg body weight revealed significant antidiabetic activity, improvement in body weight, and reduction in elevated biochemical parameters such as SGPT, SGOT, cholesterol, and triglyceride levels.
CONCLUSION: These experimental findings seemed to indicate the use of this plant in traditional Indian medicine for the treatment of diabetes.
Keywords: Antidiabetic activity; Cyperus rotundus; phytochemical analysis; rhizome; streptozotocin
References
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