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Vale A. Organophosphorus insecticide poisoning. BMJ Clin Evid. 2015;2015
Vale, A. (2015). Organophosphorus insecticide poisoning. BMJ clinical evidence, 2015.
Vale, Allister. "Organophosphorus insecticide poisoning." BMJ clinical evidence vol. 2015 (2015).
Vale A. Organophosphorus insecticide poisoning. BMJ Clin Evid. 2015 Nov 30;2015. PMID: 26618560; PMCID: PMC4664131.
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BMJ Clin Evid. 2015 Nov 30;2015.

Organophosphorus insecticide poisoning.

BMJ clinical evidence

Allister Vale

Affiliations

  1. National Poisons Information Service (Birmingham Unit) and West Midlands Poisons Unit, City Hospital Birmingham and University of Birmingham, Birmingham, UK.

PMID: 26618560 PMCID: PMC4664131

Abstract

INTRODUCTION: Acetylcholinesterase inhibition by organophosphorus insecticides can cause acute parasympathetic system dysfunction, muscle weakness, seizures, coma, and respiratory failure. Prognosis depends on the dose and relative toxicity of the specific compound, as well as pharmacokinetic factors.

METHODS AND OUTCOMES: We conducted a systematic overview, aiming to answer the following clinical question: What are the effects of oxime treatment for acute organophosphorus insecticide poisoning? We searched: Medline, Embase, The Cochrane Library, and other important databases up to October 2014 (Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview).

RESULTS: At this update, searching of electronic databases retrieved 25 studies. After deduplication and removal of conference abstracts, 14 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of eight studies and the further review of six full publications. Of the six full articles evaluated, one update of a systematic review previously included in this review was added. We performed a GRADE evaluation for six PICO combinations.

CONCLUSIONS: In this systematic overview, we categorised the efficacy for two comparisons based on information about the effectiveness and safety of oximes versus placebo or no oximes and oximes versus each other.

References

  1. Bull World Health Organ. 2003;81(11):789-98 - PubMed
  2. Scand J Work Environ Health. 2004 Oct;30(5):362-70 - PubMed
  3. Hum Exp Toxicol. 1991 Mar;10(2):113-8 - PubMed
  4. Lancet. 2005 Oct 22-28;366(9495):1452-9 - PubMed
  5. QJM. 2006 Aug;99(8):513-22 - PubMed
  6. QJM. 2000 Nov;93(11):715-31 - PubMed
  7. QJM. 2002 May;95(5):275-83 - PubMed
  8. Toxicol Rev. 2006;25(1):1-14 - PubMed
  9. J Physiol Paris. 1998 Oct-Dec;92(5-6):375-8 - PubMed
  10. J Assoc Physicians India. 1996 Aug;44(8):529-31 - PubMed
  11. Toxicol Lett. 1998 Dec 28;102-103:649-52 - PubMed
  12. J Assoc Physicians India. 2005 May;53:427-31 - PubMed
  13. Toxicology. 2012 Apr 11;294(2-3):94-103 - PubMed
  14. Int J Health Serv. 1997;27(2):273-308 - PubMed
  15. Lancet. 2006 Dec 16;368(9553):2136-41 - PubMed
  16. J Assoc Physicians India. 1995 May;43(5):321-3 - PubMed
  17. Hum Exp Toxicol. 1995 Nov;14(11):857-64 - PubMed
  18. Hum Exp Toxicol. 1997 Aug;16(8):466-72 - PubMed
  19. PLoS Med. 2009 Jun 30;6(6):e1000104 - PubMed
  20. Indian J Med Res. 1977 Sep;66(3):460-8 - PubMed
  21. Toxicol Rev. 2003;22(3):165-90 - PubMed
  22. Arch Toxicol. 2000 Mar;74(1):21-6 - PubMed

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