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Adler AL, Martin ET, Cohen G, et al. A Comprehensive Intervention Associated With Reduced Surgical Site Infections Among Pediatric Cardiovascular Surgery Patients, Including Those With Delayed Closure. J Pediatric Infect Dis Soc. 2012;1(1):35-43doi: 10.1093/jpids/pis008.
Adler, A. L., Martin, E. T., Cohen, G., Jeffries, H., Gilbert, M., Smith, J., & Zerr, D. M. (2012). A Comprehensive Intervention Associated With Reduced Surgical Site Infections Among Pediatric Cardiovascular Surgery Patients, Including Those With Delayed Closure. Journal of the Pediatric Infectious Diseases Society, 1(1), 35-43. https://doi.org/10.1093/jpids/pis008
Adler, Amanda L, et al. "A Comprehensive Intervention Associated With Reduced Surgical Site Infections Among Pediatric Cardiovascular Surgery Patients, Including Those With Delayed Closure." Journal of the Pediatric Infectious Diseases Society vol. 1,1 (2012): 35-43. doi: https://doi.org/10.1093/jpids/pis008
Adler AL, Martin ET, Cohen G, Jeffries H, Gilbert M, Smith J, Zerr DM. A Comprehensive Intervention Associated With Reduced Surgical Site Infections Among Pediatric Cardiovascular Surgery Patients, Including Those With Delayed Closure. J Pediatric Infect Dis Soc. 2012 Mar;1(1):35-43. doi: 10.1093/jpids/pis008. Epub 2012 Mar 01. PMID: 26618691.
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J Pediatric Infect Dis Soc. 2012 Mar;1(1):35-43. doi: 10.1093/jpids/pis008. Epub 2012 Mar 01.

A Comprehensive Intervention Associated With Reduced Surgical Site Infections Among Pediatric Cardiovascular Surgery Patients, Including Those With Delayed Closure.

Journal of the Pediatric Infectious Diseases Society

Amanda L Adler, Emily T Martin, Gordon Cohen, Howard Jeffries, Michael Gilbert, Julie Smith, Danielle M Zerr

Affiliations

  1. Seattle Children's Hospital, and.
  2. Seattle Children's Hospital, and Surgery, University of Washington, Seattle.
  3. Seattle Children's Hospital, and Departments of Pediatrics, and.
  4. Seattle Children's Hospital, and Departments of Pediatrics, and [email protected].

PMID: 26618691 DOI: 10.1093/jpids/pis008

Abstract

BACKGROUND: Surgical site infections (SSIs) cause significant morbidity and mortality in patients undergoing cardiovascular (CV) surgery. Following an increase in SSIs in this population, driven by a high rate in those with delayed closure, we implemented an intervention to reduce these infections and assessed the intervention using both population- and patient-level analyses.

METHODS: An intervention drawing from existing guidelines and targeting preoperative preparation of the patient, prophylactic antibiotics, and postoperative incision care was implemented. Special attention was paid to standardizing the care of the incision of patients with delayed closure. National Healthcare Safety Network criteria were used to prospectively identify SSIs. Population-level intervention effect was assessed using interrupted time series. To assess intervention adherence and effect in our patient population, retrospective chart review was performed on a cohort of patients undergoing cardiac procedures pre- and postintervention. Multivariate analysis was used to assess risk of SSI at the patient level.

RESULTS: Timely preoperative prophylactic antibiotic dosing increased from 60% preintervention to 92% postintervention, and redosing during prolonged surgeries increased from 5% to 79% (both, P < .001). At the population-level, a decrease of 6.7 infections per 100 surgeries per 6 months was observed directly following the intervention (P = .002). The SSI rate decreased from 40% to 0.8% (P < .001) in patients with delayed closure and from 4.3% to 1.8% (P = .02) in patients with immediate closure. In multivariate analyses, surgery prior to the intervention was the strongest predictor for SSI (incidence rate ratio, 3.98; 95% confidence interval, 1.59 to 9.97).

CONCLUSIONS: Our intervention decreased SSIs in pediatric CV surgery patients, particularly those with delayed closures.

© The Author 2012. Published by Oxford University Press on behalf of the Pediatric Infectious Diseases Society. All rights reserved. For Permissions, please e-mail: [email protected].

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