Display options
Cite
Alkoç OA, Songur A, Eser O, et al. Stereological and Morphometric Analysis of MRI Chiari Malformation Type-1. J Korean Neurosurg Soc. 2015;58(5):454-61doi: 10.3340/jkns.2015.58.5.454.
Alkoç, O. A., Songur, A., Eser, O., Toktas, M., Gönül, Y., Esi, E., & Haktanir, A. (2015). Stereological and Morphometric Analysis of MRI Chiari Malformation Type-1. Journal of Korean Neurosurgical Society, 58(5), 454-61. https://doi.org/10.3340/jkns.2015.58.5.454
Alkoç, Ozan Alper, et al. "Stereological and Morphometric Analysis of MRI Chiari Malformation Type-1." Journal of Korean Neurosurgical Society vol. 58,5 (2015): 454-61. doi: https://doi.org/10.3340/jkns.2015.58.5.454
Alkoç OA, Songur A, Eser O, Toktas M, Gönül Y, Esi E, Haktanir A. Stereological and Morphometric Analysis of MRI Chiari Malformation Type-1. J Korean Neurosurg Soc. 2015 Nov;58(5):454-61. doi: 10.3340/jkns.2015.58.5.454. Epub 2015 Nov 30. PMID: 26713146; PMCID: PMC4688315.
Copy Download .nbib Format: NLM
Share it on

J Korean Neurosurg Soc. 2015 Nov;58(5):454-61. doi: 10.3340/jkns.2015.58.5.454. Epub 2015 Nov 30.

Stereological and Morphometric Analysis of MRI Chiari Malformation Type-1.

Journal of Korean Neurosurgical Society

Ozan Alper Alkoç, Ahmet Songur, Olcay Eser, Muhsin Toktas, Yücel Gönül, Ertap Esi, Alpay Haktanir

Affiliations

  1. Department of Anatomy, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.
  2. Department of Anatomy, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey.
  3. Department of Neurological Surgery, Faculty of Medicine, Bal?kesir University, Bal?kesir, Turkey.
  4. Department of Anatomy, Faculty of Medicine, Turgut Özal University, Ankara, Turkey.
  5. Department of Radiology, Afyonkarahisar State Hospital, Afyon, Turkey.
  6. Department of Radiology, Faculty of Medicine, Ordu University, Ordu, Turkey.

PMID: 26713146 PMCID: PMC4688315 DOI: 10.3340/jkns.2015.58.5.454

Abstract

OBJECTIVE: In this study, we aimed to investigate the underlying ethiological factors in chiari malformation (CM) type-I (CMI) via performing volumetric and morphometric length-angle measurements.

METHODS: A total of 66 individuals [33 patients (20-65 years) with CMI and 33 control subjects] were included in this study. In sagittal MR images, tonsillar herniation length and concurrent anomalies were evaluated. Supratentorial, infratentorial, and total intracranial volumes were measured using Cavalieri method. Various cranial distances and angles were used to evaluate the platybasia and posterior cranial fossa (PCF) development.

RESULTS: Tonsillar herniation length was measured 9.09±3.39 mm below foramen magnum in CM group. Tonsillar herniation/concurrent syringomyelia, concavity/defect of clivus, herniation of bulbus and fourth ventricle, basilar invagination and craniovertebral junction abnormality rates were 30.3, 27, 18, 2, 3, and 3 percent, respectively. Absence of cisterna magna was encountered in 87.9% of the patients. Total, IT and ST volumes and distance between Chamberlain line and tip of dens axis, Klaus index, clivus length, distance between internal occipital protuberance and opisthion were significantly decreased in patient group. Also in patient group, it was found that Welcher basal angle/Boogard angle increased and tentorial slope angle decreased.

CONCLUSION: Mean cranial volume and length-angle measurement values significantly decreased and there was a congenital abnormality association in nearly 81.5 percent of the CM cases. As a result, it was concluded that CM ethiology can be attributed to multifactorial causes. Moreover, congenital defects can also give rise to this condition.

Keywords: Cavalieri method; Chiari malformation; MRI; Morphometry

References

  1. Neuroradiol J. 2013 Jun;26(3):304-9 - PubMed
  2. Neurosurgery. 1998 Feb;42(2):401-3; discussion 404 - PubMed
  3. Fetal Diagn Ther. 2010;28(1):28-33 - PubMed
  4. Radiology. 1992 May;183(2):347-53 - PubMed
  5. J Neurosurg. 2003 May;98(5):1113-5 - PubMed
  6. J Neurol Sci. 1987 Dec;82(1-3):193-203 - PubMed
  7. Neurosurgery. 1995 Aug;37(2):206-13 - PubMed
  8. Clin Anat. 2007 Oct;20(7):766-73 - PubMed
  9. Br J Radiol. 2000 Jul;73(871):679-97 - PubMed
  10. J Neurosurg. 1989 Aug;71(2):159-68 - PubMed
  11. Neurosurgery. 1999 May;44(5):1005-17 - PubMed
  12. Acta Neurochir (Wien). 1978;40(3-4):233-42 - PubMed
  13. Neurosurgery. 1993 Feb;32(2):306-9; discussion 309 - PubMed
  14. Neurosurg Rev. 2010 Jul;33(3):271-84; discussion 284-5 - PubMed
  15. J Neurol Sci. 1981 Apr;50(1):29-55 - PubMed
  16. Neuroradiology. 1993;35(2):113-8 - PubMed
  17. Childs Nerv Syst. 2008 Mar;24(3):329-36 - PubMed
  18. Eur J Radiol. 2006 Jan;57(1):96-101 - PubMed
  19. J Neurosurg Pediatr. 2008 Jan;1(1):21-4 - PubMed
  20. J Neurosurg. 2009 Nov;111(5):1046-52 - PubMed
  21. Neuroradiology. 1990;32(5):399-406 - PubMed
  22. Neurosurgery. 1994 Nov;35(5):874-84; discussion 884-5 - PubMed
  23. J Neurosurg. 1995 May;82(5):802-12 - PubMed
  24. Neurosurgery. 1992 Nov;31(5):913-7; discussion 917 - PubMed
  25. Neurosurgery. 1995 Aug;37(2):214-8 - PubMed
  26. J Neurosurg. 1994 Jun;80(6):1099-102 - PubMed
  27. J Neurosurg. 1992 Jul;77(1):69-77 - PubMed
  28. Clin Neurol Neurosurg. 2011 Jun;113(5):399-403 - PubMed
  29. J Neurosurg Spine. 2007 Dec;7(6):601-9 - PubMed
  30. Neurosurgery. 1995 Dec;37(6):1069-74 - PubMed
  31. Neurosurgery. 1993 Nov;33(5):845-9; discussion 849-50 - PubMed
  32. Acta Neurochir (Wien). 2002 Feb;144(2):165-71; discussion 171 - PubMed
  33. J Neurosurg. 1983 Feb;58(2):183-7 - PubMed
  34. J Neurosurg. 1972 Nov;37(5):543-7 - PubMed
  35. J Neurosurg. 2003 Mar;98(3):453-8 - PubMed
  36. Acta Neurochir (Wien). 2010 Jul;152(7):1117-27 - PubMed
  37. Can J Neurol Sci. 1991 May;18(2):153-69 - PubMed
  38. J Neurosurg. 1997 Jan;86(1):40-7 - PubMed

Publication Types