Display options
Cite
Sibai M, Veilleux I, Elliott JT, et al. Quantitative spatial frequency fluorescence imaging in the sub-diffusive domain for image-guided glioma resection. Biomed Opt Express. 2015;6(12):4923-33doi: 10.1364/BOE.6.004923.
Sibai, M., Veilleux, I., Elliott, J. T., Leblond, F., & Wilson, B. C. (2015). Quantitative spatial frequency fluorescence imaging in the sub-diffusive domain for image-guided glioma resection. Biomedical optics express, 6(12), 4923-33. https://doi.org/10.1364/BOE.6.004923
Sibai, Mira, et al. "Quantitative spatial frequency fluorescence imaging in the sub-diffusive domain for image-guided glioma resection." Biomedical optics express vol. 6,12 (2015): 4923-33. doi: https://doi.org/10.1364/BOE.6.004923
Sibai M, Veilleux I, Elliott JT, Leblond F, Wilson BC. Quantitative spatial frequency fluorescence imaging in the sub-diffusive domain for image-guided glioma resection. Biomed Opt Express. 2015 Nov 19;6(12):4923-33. doi: 10.1364/BOE.6.004923. eCollection 2015 Dec 01. PMID: 26713206; PMCID: PMC4679266.
Copy Download .nbib Format: NLM
Share it on

Biomed Opt Express. 2015 Nov 19;6(12):4923-33. doi: 10.1364/BOE.6.004923. eCollection 2015 Dec 01.

Quantitative spatial frequency fluorescence imaging in the sub-diffusive domain for image-guided glioma resection.

Biomedical optics express

Mira Sibai, Israel Veilleux, Jonathan T Elliott, Frederic Leblond, Brian C Wilson

Affiliations

  1. Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, ON M5G 1L7 Canada ; Princess Margaret Cancer Center/University Health Network, 610 University Avenue, Toronto, ON M5G 2M3 Canada.
  2. Princess Margaret Cancer Center/University Health Network, 610 University Avenue, Toronto, ON M5G 2M3 Canada.
  3. Thayer School of Engineering at Dartmouth, Thayer School of Engineering at Dartmouth 14 Engineering Drive Hanover, NH USA 03755 USA.
  4. École Polytechnique De Montreal, 2900, boul. Édouard-Montpetit Montréal, Québec H3T 1J4 Canada.

PMID: 26713206 PMCID: PMC4679266 DOI: 10.1364/BOE.6.004923

Abstract

Intraoperative 5- aminolevulinic acid induced-Protoporphyrin IX (PpIX) fluorescence guidance enables maximum safe resection of glioblastomas by providing surgeons with real-time tumor optical contrast. However, visual assessment of PpIX fluorescence is subjective and limited by the distorting effects of light attenuation and tissue autofluorescence. We have previously shown that non-invasive point measurements of absolute PpIX concentration identifies residual tumor that is otherwise non-detectable. Here, we extend this approach to wide-field quantitative fluorescence imaging by implementing spatial frequency domain imaging to recover tissue optical properties across the field-of-view in phantoms and ex vivo tissue.

Keywords: (110.0110) Imaging systems; (110.0113) Imaging through turbid media; (170.6510) Spectroscopy, tissue diagnostics

References

  1. J Biomed Opt. 2013 Nov;18(11):117010 - PubMed
  2. Opt Express. 2008 Apr 14;16(8):5907-25 - PubMed
  3. Photochem Photobiol. 2004 Jul-Aug;80:98-103 - PubMed
  4. J Biomed Opt. 2011 Dec;16(12 ):126013 - PubMed
  5. J Clin Neurosci. 2012 Dec;19(12 ):1611-6 - PubMed
  6. J Clin Neurosci. 2012 Nov;19(11):1471-4 - PubMed
  7. Lancet Oncol. 2006 May;7(5):392-401 - PubMed
  8. Opt Lett. 2013 Aug 1;38(15):2786-8 - PubMed
  9. J Biomed Opt. 2013 Aug;18(8):80503 - PubMed
  10. J Neurosurg. 2011 Jul;115(1):11-7 - PubMed
  11. J Biomed Opt. 2013 Sep;18(9):096007 - PubMed
  12. J Biomed Opt. 2010 Nov-Dec;15(6):067006 - PubMed
  13. J Biomed Opt. 2013 Mar;18(3):036012 - PubMed
  14. J Biomed Opt. 2011 Nov;16(11):116007 - PubMed
  15. Biomed Opt Express. 2014 Jun 04;5(7):2037-53 - PubMed
  16. J Biomed Opt. 2009 May-Jun;14 (3):030501 - PubMed
  17. J Biomed Opt. 2010 May-Jun;15(3):036013 - PubMed
  18. J Biomed Opt. 2009 Mar-Apr;14(2):024012 - PubMed

Publication Types

Grant support