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Michaelsen KE, Krishnaswamy V, Shi L, et al. Calibration and optimization of 3D digital breast tomosynthesis guided near infrared spectral tomography. Biomed Opt Express. 2015;6(12):4981-91doi: 10.1364/BOE.6.004981.
Michaelsen, K. E., Krishnaswamy, V., Shi, L., Vedantham, S., Poplack, S. P., Karellas, A., Pogue, B. W., & Paulsen, K. D. (2015). Calibration and optimization of 3D digital breast tomosynthesis guided near infrared spectral tomography. Biomedical optics express, 6(12), 4981-91. https://doi.org/10.1364/BOE.6.004981
Michaelsen, Kelly E, et al. "Calibration and optimization of 3D digital breast tomosynthesis guided near infrared spectral tomography." Biomedical optics express vol. 6,12 (2015): 4981-91. doi: https://doi.org/10.1364/BOE.6.004981
Michaelsen KE, Krishnaswamy V, Shi L, Vedantham S, Poplack SP, Karellas A, Pogue BW, Paulsen KD. Calibration and optimization of 3D digital breast tomosynthesis guided near infrared spectral tomography. Biomed Opt Express. 2015 Nov 19;6(12):4981-91. doi: 10.1364/BOE.6.004981. eCollection 2015 Dec 01. PMID: 26713210; PMCID: PMC4679270.
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Biomed Opt Express. 2015 Nov 19;6(12):4981-91. doi: 10.1364/BOE.6.004981. eCollection 2015 Dec 01.

Calibration and optimization of 3D digital breast tomosynthesis guided near infrared spectral tomography.

Biomedical optics express

Kelly E Michaelsen, Venkataramanan Krishnaswamy, Linxi Shi, Srinivasan Vedantham, Steven P Poplack, Andrew Karellas, Brian W Pogue, Keith D Paulsen

Affiliations

  1. Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
  2. Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA ; Currently at School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
  3. Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
  4. Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA ; Currently at Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

PMID: 26713210 PMCID: PMC4679270 DOI: 10.1364/BOE.6.004981

Abstract

Calibration of a three-dimensional multimodal digital breast tomosynthesis (DBT) x-ray and non-fiber based near infrared spectral tomography (NIRST) system is challenging but essential for clinical studies. Phantom imaging results yielded linear contrast recovery of total hemoglobin (HbT) concentration for cylindrical inclusions of 15 mm, 10 mm and 7 mm with a 3.5% decrease in the HbT estimate for each 1 cm increase in inclusion depth. A clinical exam of a patient's breast containing both benign and malignant lesions was successfully imaged, with greater HbT was found in the malignancy relative to the benign abnormality and fibroglandular regions (11 μM vs. 9.5 μM). Tools developed improved imaging system characterization and optimization of signal quality, which will ultimately improve patient selection and subsequent clinical trial results.

Keywords: (120.3890) Medical optics instrumentation; (170.0110) Imaging systems; (170.3830) Mammography

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