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Langston JW, Schüle B, Rees L, et al. Multisystem Lewy body disease and the other parkinsonian disorders. Nat Genet. 2015;47(12):1378-84doi: 10.1038/ng.3454.
Langston, J. W., Schüle, B., Rees, L., Nichols, R. J., & Barlow, C. (2015). Multisystem Lewy body disease and the other parkinsonian disorders. Nature genetics, 47(12), 1378-84. https://doi.org/10.1038/ng.3454
Langston, J William, et al. "Multisystem Lewy body disease and the other parkinsonian disorders." Nature genetics vol. 47,12 (2015): 1378-84. doi: https://doi.org/10.1038/ng.3454
Langston JW, Schüle B, Rees L, Nichols RJ, Barlow C. Multisystem Lewy body disease and the other parkinsonian disorders. Nat Genet. 2015 Dec;47(12):1378-84. doi: 10.1038/ng.3454. PMID: 26620112.
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Nat Genet. 2015 Dec;47(12):1378-84. doi: 10.1038/ng.3454.

Multisystem Lewy body disease and the other parkinsonian disorders.

Nature genetics

J William Langston, Birgitt Schüle, Linda Rees, R Jeremy Nichols, Carrolee Barlow

Affiliations

  1. Parkinson's Institute and Clinical Center, Sunnyvale, California, USA.

PMID: 26620112 DOI: 10.1038/ng.3454

Abstract

Here we prioritize as multisystem Lewy body disease (MLBD) those genetic forms of Parkinson's disease that point the way toward a mechanistic understanding of the majority of sporadic disease. Pathological diagnosis of genetic subtypes offers the prospect of distinguishing different mechanistic trajectories with a common mutational etiology, differing outcomes from varying allelic bases, and those disease-associated variants that can be used in gene-environment analysis. Clearly delineating parkinsonian disorders into subclasses on the basis of molecular mechanisms with well-characterized outcome expectations is the basis for refining these forms of neurodegeneration as research substrate through the use of cell models derived from affected individuals while ensuring that clinically collected data can be used for therapeutic decisions and research without increasing the noise and confusion engendered by the collection of data against a range of historically defined criteria.

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