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Hara N, Fujimoto N, Miyamoto Y, et al. Lymphoproliferative disorder in pleural effusion in a subject with past asbestos exposure. Respir Med Case Rep. 2015;16:169-71doi: 10.1016/j.rmcr.2015.11.002.
Hara, N., Fujimoto, N., Miyamoto, Y., Yamagishi, T., Asano, M., Fuchimoto, Y., Wada, S., Ozaki, S., & Kishimoto, T. (2015). Lymphoproliferative disorder in pleural effusion in a subject with past asbestos exposure. Respiratory medicine case reports, 16169-71. https://doi.org/10.1016/j.rmcr.2015.11.002
Hara, Naofumi, et al. "Lymphoproliferative disorder in pleural effusion in a subject with past asbestos exposure." Respiratory medicine case reports vol. 16 (2015): 169-71. doi: https://doi.org/10.1016/j.rmcr.2015.11.002
Hara N, Fujimoto N, Miyamoto Y, Yamagishi T, Asano M, Fuchimoto Y, Wada S, Ozaki S, Kishimoto T. Lymphoproliferative disorder in pleural effusion in a subject with past asbestos exposure. Respir Med Case Rep. 2015 Nov 23;16:169-71. doi: 10.1016/j.rmcr.2015.11.002. eCollection 2015. PMID: 26744692; PMCID: PMC4681999.
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Respir Med Case Rep. 2015 Nov 23;16:169-71. doi: 10.1016/j.rmcr.2015.11.002. eCollection 2015.

Lymphoproliferative disorder in pleural effusion in a subject with past asbestos exposure.

Respiratory medicine case reports

Naofumi Hara, Nobukazu Fujimoto, Yosuke Miyamoto, Tomoko Yamagishi, Michiko Asano, Yasuko Fuchimoto, Sae Wada, Shinji Ozaki, Takumi Kishimoto

Affiliations

  1. Department of Respiratory Medicine, Okayama Rosai Hospital, Okayama, Japan.
  2. Department of Medical Oncology, Okayama Rosai Hospital, Okayama, Japan.
  3. Department of Internal Medicine, Okayama Rosai Hospital, Okayama, Japan.

PMID: 26744692 PMCID: PMC4681999 DOI: 10.1016/j.rmcr.2015.11.002

Abstract

Primary effusion lymphoma (PEL) is a subtype of non-Hodgkin lymphoma that presents as serous effusions without detectable masses or organomegaly. Here we report a case of PEL-like lymphoma in a patient with past asbestos exposure. A 65-year-old man was referred to our hospital due to dyspnea upon exertion. He had been exposed to asbestos for three years in the construction industry. Chest X-ray and CT images demonstrated left pleural effusion. Cytological analysis of the pleural effusion revealed large atypical lymphocytes with distinct nuclear bodies and high nucleus-to-cytoplasm ratio. Immunohistochemical analyses showed that the cells were CD20(+), CD3(-), CD5(-), and CD10(-). These findings led to a diagnosis of diffuse large B-cell lymphoma. PEL or PEL-like lymphoma should be considered a potential cause of pleural effusion in subjects with past asbestos exposure.

Keywords: Asbestos; CT, computed tomography; DLBCL, diffuse large B-cell lymphoma; HHV, human herpesvirus; Lymphoma; Mesothelioma; PEL, primary effusion lymphoma; Pleural effusion; Thoracoscopy

References

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