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Zheng M, Zang S, Xie L, et al. Rheb phosphorylation is involved in p38-regulated/activated protein kinase-mediated tumor suppression in liver cancer. Oncol Lett. 2015;10(3):1655-1661doi: 10.3892/ol.2015.3406.
Zheng, M., Zang, S., Xie, L., Fang, X., Zhang, Y. U., Ma, X., Liu, J., Lin, D., & Huang, A. (2015). Rheb phosphorylation is involved in p38-regulated/activated protein kinase-mediated tumor suppression in liver cancer. Oncology letters, 10(3), 1655-1661. https://doi.org/10.3892/ol.2015.3406
Zheng, Min, et al. "Rheb phosphorylation is involved in p38-regulated/activated protein kinase-mediated tumor suppression in liver cancer." Oncology letters vol. 10,3 (2015): 1655-1661. doi: https://doi.org/10.3892/ol.2015.3406
Zheng M, Zang S, Xie L, Fang X, Zhang YU, Ma X, Liu J, Lin D, Huang A. Rheb phosphorylation is involved in p38-regulated/activated protein kinase-mediated tumor suppression in liver cancer. Oncol Lett. 2015 Sep;10(3):1655-1661. doi: 10.3892/ol.2015.3406. Epub 2015 Jun 22. PMID: 26622727; PMCID: PMC4533698.
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Oncol Lett. 2015 Sep;10(3):1655-1661. doi: 10.3892/ol.2015.3406. Epub 2015 Jun 22.

Rheb phosphorylation is involved in p38-regulated/activated protein kinase-mediated tumor suppression in liver cancer.

Oncology letters

Min Zheng, Shengbing Zang, Linna Xie, Xueting Fang, Y U Zhang, Xiaojie Ma, Jingfeng Liu, Dexin Lin, Aimin Huang

Affiliations

  1. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350004, P.R. China ; Translational Medicine Institute, Fujian Medical University, Fuzhou, Fujian 350004, P.R. China.
  2. Department of Pathology and Institute of Oncology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350004, P.R. China.
  3. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350004, P.R. China ; Department of Bioengineering, Fujian Vocational College of Bioengineering, Fuzhou, Fujian 350007, P.R. China.
  4. Liver Center of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, P.R. China.
  5. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350004, P.R. China.

PMID: 26622727 PMCID: PMC4533698 DOI: 10.3892/ol.2015.3406

Abstract

Ras homolog enriched in brain (Rheb) is a key regulator of mammalian target of rapamycin complex 1 (mTORC1). The Rheb-mTORC1 axis is a pivotal pathway that mediates cell growth. It was previously reported that upon energy-stress stimulation, the phosphorylation of Rheb at serine 130 by p38-regulated/activated protein kinase (PRAK) results in the impaired nucleotide binding ability of Rheb and inhibits Rheb-mediated mTORC1 activation. However, the role of Rheb phosphorylation in cancer development remains to be elucidated. The aim of the present study was to determine the effect of Rheb phosphorylation on tumor growth

Keywords: Ras; Rheb phosphorylation; liver cancer; p38-regulated/activated protein kinase

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