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Yuan X, Wang LU, Xue J, et al. Endocrine MPA enhances the effects of TAC chemotherapy on improvement of prognosis and increase in long-term survival rates for patients with endometrial cancer. Oncol Lett. 2015;10(3):1902-1906doi: 10.3892/ol.2015.3395.
Yuan, X., Wang, L. U., Xue, J., Li, L. I., & Zhang, J. (2015). Endocrine MPA enhances the effects of TAC chemotherapy on improvement of prognosis and increase in long-term survival rates for patients with endometrial cancer. Oncology letters, 10(3), 1902-1906. https://doi.org/10.3892/ol.2015.3395
Yuan, Xiuhong, et al. "Endocrine MPA enhances the effects of TAC chemotherapy on improvement of prognosis and increase in long-term survival rates for patients with endometrial cancer." Oncology letters vol. 10,3 (2015): 1902-1906. doi: https://doi.org/10.3892/ol.2015.3395
Yuan X, Wang LU, Xue J, Li LI, Zhang J. Endocrine MPA enhances the effects of TAC chemotherapy on improvement of prognosis and increase in long-term survival rates for patients with endometrial cancer. Oncol Lett. 2015 Sep;10(3):1902-1906. doi: 10.3892/ol.2015.3395. Epub 2015 Jun 19. PMID: 26622772; PMCID: PMC4533712.
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Oncol Lett. 2015 Sep;10(3):1902-1906. doi: 10.3892/ol.2015.3395. Epub 2015 Jun 19.

Endocrine MPA enhances the effects of TAC chemotherapy on improvement of prognosis and increase in long-term survival rates for patients with endometrial cancer.

Oncology letters

Xiuhong Yuan, L U Wang, Juan Xue, L I Li, Jing Zhang

Affiliations

  1. Department of Gynecology and Obstetrics, The Affiliated Hospital of Yan'an University, Yan'an, Shaanxi 716000, P.R. China.
  2. Department of Neurobiology, Medical School of Yan'an University, Yan'an, Shaanxi 716000, P.R. China.

PMID: 26622772 PMCID: PMC4533712 DOI: 10.3892/ol.2015.3395

Abstract

The aim of the present study was to investigate the effect of taxol, adriamycin and carboplatin (TAC) chemotherapy combined with endocrine medroxyprogesterone acetate (MPA) therapy for the treatment of patients with endometrial cancer. A retrospective analysis of 124 patients with endometrial cancer was performed by dividing the cohort into an experimental and control group. The 64 patients in the experimental group received TAC and MPA chemotherapy, whereas the 60 patients in the control group were treated with TAC chemotherapy only. Tissue samples scraped from the uterus were used to extract the total proteins and RNAs for the western blot and reverse transcription-quantitative polymerase chain reaction analyses, respectively. All the patients were followed up for 20-45 months, during which time prognostic data, and one- to three-year survival rates were recorded and compared. The rate of recurrence or metastasis was significantly lower in the experimental group compared with that in the control group (P<0.05) and the three-year survival rate of the experimental group was significantly higher than that of the control group (P<0.05). Furthermore, the mean metastasis-associated 1 (MTA1) protein and RNA expression levels were significantly lower in the experimental group compared with the control group (P<0.05), exhibiting ~30 and ~15% of the levels in the control group, respectively. Therefore, a treatment strategy of TAC chemotherapy combined with endocrine MPA therapy appears to effectively improve the prognosis and increase the long-term survival rates of patients with endometrial cancer. Such an enhancing effect may be mediated by the transcriptional downregulation of MTA1 expression.

Keywords: adriamycin; carboplatin; chemotherapy; endocrine therapy; endometrial cancer; taxol

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