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Ansari B, Basiri K, Meamar R, et al. Association of Helicobacter pylori antibodies and severity of migraine attack. Iran J Neurol. 2015;14(3):125-9
Ansari, B., Basiri, K., Meamar, R., Chitsaz, A., & Nematollahi, S. (2015). Association of Helicobacter pylori antibodies and severity of migraine attack. Iranian journal of neurology, 14(3), 125-9.
Ansari, Behnaz, et al. "Association of Helicobacter pylori antibodies and severity of migraine attack." Iranian journal of neurology vol. 14,3 (2015): 125-9.
Ansari B, Basiri K, Meamar R, Chitsaz A, Nematollahi S. Association of Helicobacter pylori antibodies and severity of migraine attack. Iran J Neurol. 2015 Jul 06;14(3):125-9. PMID: 26622976; PMCID: PMC4662684.
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Iran J Neurol. 2015 Jul 06;14(3):125-9.

Association of Helicobacter pylori antibodies and severity of migraine attack.

Iranian journal of neurology

Behnaz Ansari, Keivan Basiri, Rokhsareh Meamar, Ahmad Chitsaz, Shahrzad Nematollahi

Affiliations

  1. Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  2. Isfahan Neurosciences Research Center, Al-zahra Hospital, Isfahan University of Medical Sciences AND Department of Medical Sciences, School of Medicine, Islamic Azad University, Najafabad Branch, Isfahan, Iran.
  3. Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.

PMID: 26622976 PMCID: PMC4662684

Abstract

BACKGROUND: Recent studies have shown a positive correlation between Helicobacter pylori infection and migraine headache. The aim of this study was to evaluate the role of H. pylori infection in migraine headache with (MA) and without aura (MO).

METHODS: This is a case-control study containing information on 84 patients (including MA, MO) and 49 healthy individuals. The enzyme-linked immunosorbent assay (ELISA) test was used to measure immunoglobulin G (IgG,) immunoglobulin M (IgM) titer in two groups. Headache severity was evaluated according to Headache Impact Test (HIT6) questionnaire.

RESULTS: Mean ± SD of IgM antibody in Migrainous patients 26.3 (23.1) showed significantly difference with control group 17.5 (11.2) (P = 0.004). In addition, the mean ± SD HIT6 in Migrainous patients differed significantly between MA and MO groups 65.5 (4.7), 54.9 (5.3) respectively, P < 0.001). The only significant correlation was found for IgG antibody and HIT6 in MA patients (r = 0.407, P = 0.011) and MO group (r = 0.499, P = 0.002). The risk of migraine occurrence in patients did not significantly associate with the level of IgG and IgM antibodies.

CONCLUSION: The results give a hope that definite treatment and eradication of this bacterium could be a cure or to reduce the severity and course of migraine headaches.

Keywords: Head Pain; Helicobacter Pylori; Migraine

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