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Nakajima T, Yagi H, Baba H, et al. Complete Resolution of Pseudomalignant Erosion in a Reflux Gastroesophageal Polyp with Proton Pump Inhibitor. Case Rep Pathol. 2015;2015:657059doi: 10.1155/2015/657059.
Nakajima, T., Yagi, H., Baba, H., Minamisaka, T., Miwa, S., Hayashi, S., Nishida, T., Hatta, H., Tsuneyama, K., & Imura, J. (2015). Complete Resolution of Pseudomalignant Erosion in a Reflux Gastroesophageal Polyp with Proton Pump Inhibitor. Case reports in pathology, 2015657059. https://doi.org/10.1155/2015/657059
Nakajima, Takahiko, et al. "Complete Resolution of Pseudomalignant Erosion in a Reflux Gastroesophageal Polyp with Proton Pump Inhibitor." Case reports in pathology vol. 2015 (2015): 657059. doi: https://doi.org/10.1155/2015/657059
Nakajima T, Yagi H, Baba H, Minamisaka T, Miwa S, Hayashi S, Nishida T, Hatta H, Tsuneyama K, Imura J. Complete Resolution of Pseudomalignant Erosion in a Reflux Gastroesophageal Polyp with Proton Pump Inhibitor. Case Rep Pathol. 2015;2015:657059. doi: 10.1155/2015/657059. Epub 2015 Nov 24. PMID: 26688768; PMCID: PMC4672133.
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Case Rep Pathol. 2015;2015:657059. doi: 10.1155/2015/657059. Epub 2015 Nov 24.

Complete Resolution of Pseudomalignant Erosion in a Reflux Gastroesophageal Polyp with Proton Pump Inhibitor.

Case reports in pathology

Takahiko Nakajima, Haruo Yagi, Hayato Baba, Takashi Minamisaka, Shigeharu Miwa, Shinichi Hayashi, Takeshi Nishida, Hideki Hatta, Koichi Tsuneyama, Johji Imura

Affiliations

  1. Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
  2. Department of Surgery, Kouseiren Namerikawa Hospital, 119 Tokiwa-cho, Namerikawa 936-8585, Japan.
  3. Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan ; Department of Molecular and Environmental Pathology, Institute of Health Biosciences, University of Tokushima Graduate School, 3-8-15 Kuramotomachi, Tokushima 770-8503, Japan.

PMID: 26688768 PMCID: PMC4672133 DOI: 10.1155/2015/657059

Abstract

Pseudomalignant erosion is a diagnostic pitfall for pathologists in the differential diagnosis of malignant neoplasms. Here, we present a challenging case of a biopsy specimen from the eroded head of a polyp at the esophagogastric junction. A malignant neoplasm could not be ruled out due to the presence of bizarre stromal cells. A second biopsy performed after the administration of a proton pump inhibitor (PPI) for 4 weeks revealed endoscopic resolution of the polyp along with the complete histological resolution of the bizarre stromal cells and led to the diagnosis of pseudomalignant erosion in a reflux gastroesophageal polyp. In conclusion, histological and endoscopic response to PPI therapy is an important clue for the correct diagnosis of reflux gastroesophageal polyps with pseudomalignant erosion.

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