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Merghni A, Marzouki H, Hentati H, et al. Antibacterial and antibiofilm activities of Laurus nobilis L. essential oil against Staphylococcus aureus strains associated with oral infections. Pathol Biol (Paris). 2015;doi: 10.1016/j.patbio.2015.10.003.
Merghni, A., Marzouki, H., Hentati, H., Aouni, M., & Mastouri, M. (2015). Antibacterial and antibiofilm activities of Laurus nobilis L. essential oil against Staphylococcus aureus strains associated with oral infections. Pathologie-biologie, . https://doi.org/10.1016/j.patbio.2015.10.003
Merghni, A, et al. "Antibacterial and antibiofilm activities of Laurus nobilis L. essential oil against Staphylococcus aureus strains associated with oral infections." Pathologie-biologie vol. (2015). doi: https://doi.org/10.1016/j.patbio.2015.10.003
Merghni A, Marzouki H, Hentati H, Aouni M, Mastouri M. Antibacterial and antibiofilm activities of Laurus nobilis L. essential oil against Staphylococcus aureus strains associated with oral infections. Pathol Biol (Paris). 2015 Dec 04; doi: 10.1016/j.patbio.2015.10.003. Epub 2015 Dec 04. PMID: 26657812.
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Pathol Biol (Paris). 2015 Dec 04; doi: 10.1016/j.patbio.2015.10.003. Epub 2015 Dec 04.

Antibacterial and antibiofilm activities of Laurus nobilis L. essential oil against Staphylococcus aureus strains associated with oral infections.

Pathologie-biologie

A Merghni, H Marzouki, H Hentati, M Aouni, M Mastouri

Affiliations

  1. Laboratory of infectious diseases and biological agents (LR99ES27), faculty of pharmacy, Monastir university, avenue Avicenne, 5000 Monastir, Tunisia. Electronic address: [email protected].
  2. Laboratory of infectious diseases and biological agents (LR99ES27), faculty of pharmacy, Monastir university, avenue Avicenne, 5000 Monastir, Tunisia.
  3. Buccodental surgery department of Monastir dental clinic, laboratory of oral health and orofacial rehabilitation (LR12ES11), Monastir, Tunisia.
  4. Laboratory of infectious diseases and biological agents (LR99ES27), faculty of pharmacy, Monastir university, avenue Avicenne, 5000 Monastir, Tunisia; Laboratory of microbiology, university hospital of Fattouma Bourguiba, Monastir, Tunisia.

PMID: 26657812 DOI: 10.1016/j.patbio.2015.10.003

Abstract

BACKGROUND: Laurus nobilis L. is an aromatic herb with relevant medicinal properties due to its important chemical composition and its potential therapeutic effects. In this study, we investigate the chemical composition, the antibacterial and the antibiofilms activities of Tunisian L. nobilis L. essential oils against clinical Staphylococcus aureus strains.

METHODS: The chemical composition of L. nobilis L. essential oils was analysed by Gas Chromatography-Mass Spectrometry (GC-MS). The antibacterial activity of L. nobilis L. essential oils was evaluated in vitro against oral S. aureus (n=21) strains using broth microdilution method. The antibiofilm activity was assessed via Crystal Violet staining and MTT assays.

RESULTS: Our results revealed that GC-MS assay exhibited 1.8-Cineole, methyl eugenol and α-terpinyl acetate as the major compounds in the essential oils. Moreover, the essential oil from Sousse exhibited the best bactericidal activity (MICs values ranged from 3.91 to 15.62mgm

CONCLUSION: Our finding demonstrated that L. nobilis L. essential oils are able to inhibit oral S. aureus strains with important antibiofilm efficacy. It could have a promising role in the prevention of oral diseases.

Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Keywords: Activité anti-staphylococcique; Activité antibiofilm; Anti-staphylococcal activity; Antibiofilm activity; CG–SM; Essential oil; GC–MS analysis; Huile essentielle; Laurus nobilis L.

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