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Holschneider DP, Guo Y, Mayer EA, et al. Early life stress elicits visceral hyperalgesia and functional reorganization of pain circuits in adult rats. Neurobiol Stress. 2016;3:8-22doi: 10.1016/j.ynstr.2015.12.003.
Holschneider, D. P., Guo, Y., Mayer, E. A., & Wang, Z. (2016). Early life stress elicits visceral hyperalgesia and functional reorganization of pain circuits in adult rats. Neurobiology of stress, 38-22. https://doi.org/10.1016/j.ynstr.2015.12.003
Holschneider, D P, et al. "Early life stress elicits visceral hyperalgesia and functional reorganization of pain circuits in adult rats." Neurobiology of stress vol. 3 (2016): 8-22. doi: https://doi.org/10.1016/j.ynstr.2015.12.003
Holschneider DP, Guo Y, Mayer EA, Wang Z. Early life stress elicits visceral hyperalgesia and functional reorganization of pain circuits in adult rats. Neurobiol Stress. 2016 Jun 01;3:8-22. doi: 10.1016/j.ynstr.2015.12.003. PMID: 26751119; PMCID: PMC4700548.
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Neurobiol Stress. 2016 Jun 01;3:8-22. doi: 10.1016/j.ynstr.2015.12.003.

Early life stress elicits visceral hyperalgesia and functional reorganization of pain circuits in adult rats.

Neurobiology of stress

D P Holschneider, Y Guo, E A Mayer, Z Wang

Affiliations

  1. Department of Psychiatry and Behavioral Sciences, University of Southern California, Los Angeles, CA, USA; Departments of Neurology, Cell and Neurobiology, Biomedical Engineering, University of Southern California, Los Angeles, CA, USA; Center for Neurobiology of Stress, Department of Medicine, University of California Los Angeles, Los Angeles, California, USA.
  2. Department of Psychiatry and Behavioral Sciences, University of Southern California, Los Angeles, CA, USA.
  3. Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, California, United States of America; Center for Neurobiology of Stress, Department of Medicine, University of California Los Angeles, Los Angeles, California, USA; Departments of Physiology, Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California, USA.
  4. Department of Psychiatry and Behavioral Sciences, University of Southern California, Los Angeles, CA, USA; Center for Neurobiology of Stress, Department of Medicine, University of California Los Angeles, Los Angeles, California, USA.

PMID: 26751119 PMCID: PMC4700548 DOI: 10.1016/j.ynstr.2015.12.003

Abstract

Early life stress (ELS) is a risk factor for developing functional gastrointestinal disorders, and has been proposed to be related to a central amplification of sensory input and resultant visceral hyperalgesia. We sought to characterize ELS-related changes in functional brain responses during acute noxious visceral stimulation. Neonatal rats (males/females) were exposed to limited bedding (ELS) or standard bedding (controls) on postnatal days 2-9. Age 10-11 weeks, animals were implanted with venous cannulas and transmitters for abdominal electromyography (EMG). Cerebral blood flow (rCBF) was mapped during colorectal distension (CRD) using [

Keywords: brain mapping; early life stress; nesting behavior; nociception; sex differences; visceral pain

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