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Salah S, El-Masry SA, Sheba HF, et al. Bone Mineral Density in Egyptian Children with Familial Mediterranean Fever. Iran J Med Sci. 2016;41(1):2-8
Salah, S., El-Masry, S. A., Sheba, H. F., El-Banna, R. A., & Saad, W. (2016). Bone Mineral Density in Egyptian Children with Familial Mediterranean Fever. Iranian journal of medical sciences, 41(1), 2-8.
Salah, Samia, et al. "Bone Mineral Density in Egyptian Children with Familial Mediterranean Fever." Iranian journal of medical sciences vol. 41,1 (2016): 2-8.
Salah S, El-Masry SA, Sheba HF, El-Banna RA, Saad W. Bone Mineral Density in Egyptian Children with Familial Mediterranean Fever. Iran J Med Sci. 2016 Jan;41(1):2-8. PMID: 26722138; PMCID: PMC4691266.
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Iran J Med Sci. 2016 Jan;41(1):2-8.

Bone Mineral Density in Egyptian Children with Familial Mediterranean Fever.

Iranian journal of medical sciences

Samia Salah, Sahar A El-Masry, Hala Fathy Sheba, Rokia A El-Banna, Walaa Saad

Affiliations

  1. Rheumatology Department, Abo El-Rish Children Hospital, Cairo University, Giza, Egypt.
  2. Biological Anthropology Department, Medical Research Division, National Research Centre, Giza, Egypt.
  3. Clinical Pathology Department, Kasr El-Aini Hospital, Cairo University, Giza, Egypt.

PMID: 26722138 PMCID: PMC4691266

Abstract

BACKGROUND: Familial Mediterranean fever (FMF) has episodic or subclinical inflammation that may lead to a decrease in bone mineral density (BMD). The objective of this study was to assess BMD in Egyptian children with FMF on genetic basis.

METHODS: A cross sectional study included 45 FMF patients and 25 control children of both sexes in the age range between 3-16 years old. The patients were reclassified into two groups, namely group I(A) with 23 cases using colchicine for 1 month or less, and group I(B) with 22 cases using colchicine for more than 6 months. For both the patients and control groups, MEFV mutations were defined using molecular genetics technique and BMD was measured by DXA at the proximal femur and lumbar spines.

RESULTS: Four frequent gene mutations were found in the patient group E148Q (35.6%), V726A (33.3%), M680I (28.9%), and M694V (2.2%). There were also four heterozygous gene mutations in 40% of the control children. Patients receiving colchicine treatment for less than 1 month had highly significant lower values of BMD at the femur and lumbar spines than the control children (P=0.007, P<0.001). Patients receiving colchicine treatment for more than 6 months had improved values of BMD at femur compared with the control, but there were still significant differences between them in lumbar spine (P=0.036). There were insignificant effect of gene mutation type on BMD and the risk of osteopenia among the patients.

CONCLUSION: FMF had a significant effect on BMD. However, regular use of colchicine treatment improves this effect mainly at the femur.

Keywords: Bone density; Children; Familial mediterranean fever; Genes

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