Display options
Cite
Wang JB, Li H, Wang LL, et al. Role of IL-1β, IL-6, IL-8 and IFN-γ in pathogenesis of central nervous system neuropsychiatric systemic lupus erythematous. Int J Clin Exp Med. 2015;8(9):16658-63
Wang, J. B., Li, H., Wang, L. L., Liang, H. D., Zhao, L., & Dong, J. (2015). Role of IL-1β, IL-6, IL-8 and IFN-γ in pathogenesis of central nervous system neuropsychiatric systemic lupus erythematous. International journal of clinical and experimental medicine, 8(9), 16658-63.
Wang, Ji-Bo, et al. "Role of IL-1β, IL-6, IL-8 and IFN-γ in pathogenesis of central nervous system neuropsychiatric systemic lupus erythematous." International journal of clinical and experimental medicine vol. 8,9 (2015): 16658-63.
Wang JB, Li H, Wang LL, Liang HD, Zhao L, Dong J. Role of IL-1β, IL-6, IL-8 and IFN-γ in pathogenesis of central nervous system neuropsychiatric systemic lupus erythematous. Int J Clin Exp Med. 2015 Sep 15;8(9):16658-63. eCollection 2015. PMID: 26629199; PMCID: PMC4659087.
Copy Download .nbib Format: NLM
Share it on

Int J Clin Exp Med. 2015 Sep 15;8(9):16658-63. eCollection 2015.

Role of IL-1β, IL-6, IL-8 and IFN-γ in pathogenesis of central nervous system neuropsychiatric systemic lupus erythematous.

International journal of clinical and experimental medicine

Ji-Bo Wang, Hua Li, Li-Li Wang, Hong-Da Liang, Lei Zhao, Jing Dong

Affiliations

  1. Department of Rheumatology, Clinical Immunology, The Affiliated Hospital of Qingdao University Qingdao 266003, China.

PMID: 26629199 PMCID: PMC4659087

Abstract

We discussed the role of IL-1β, IL-6, IL-8 and IFN-γ in the pathogenesis of central nervous system neuropsychiatric systemic lupus erythematous (CNS-NPSLE). Serum and cerebrospinal fluid samples were collected from CNS-NPSLE patients, non-CNS SLE patients, patients with intracranial infection and normal subjects. Levels of IL-1β, IL-6, IL-8 and IFN-γ in serum and cerebrospinal fluid were detected by ELISA, and the results were compared across the groups. All subjects received cerebral MRI. The risk threshold for each cytokine in CNS-NPSLE group was set as 2.5%. The positive rates of cytokines for different lesions in cerebral MRI findings in CNS-NPSLE group were compared. The correlations between cytokine levels and cerebral MRI findings were analyzed. All groups did not show significant differences in age and gender (F=1.34, P>0.05; x (2)=2.05, P>0.05); The IL-1β, IL-6, IL-8 and IFN-γ levels of serum and cerebrospinal fluid in CNS-NPSLE group were obviously higher than those of the normal control (serum Z14 =6.22, 6.04, 6.22, 5.70; cerebrospinal fluid Z14 =6.38, 7.10, 6.97, 6.34, P<0.0083); IL-1β, IL-6 and IL-8 levels of cerebrospinal fluid of CNS-NPSLE group were higher than those of the non-CNS SLE group (Z12 =2.73, Z12 =3.18, Z12 =3.86; P<0.0083); IL-1β, IL-6, IL-8 and IFN-γ levels of cerebrospinal fluid of CNS-NPSLE group were higher than those of the serum (Z=3.19, 6.30, 5.44, 3.19, P<0.05); IL-6>20.0679 pg/ml and IL-8>87.1811 pg/ml in the cerebrospinal fluid predicted a higher risk of CNS-NPSLE (x (2)=11.98, P<0.05; x (2)=4.65, P<0.05); The positive rates of IL-1β and IL-6 in the cerebrospinal fluid of CNS-NPSLE patients with demyelinating diseases were considerably higher than those of CNS-NPSLE patients with normal MRI findings (x (2)=10.89, P<0.005; x (2)=18.47, P<0.005). The positive rates of IL-6 and IFN-γ in the cerebrospinal fluid of CNS-NPSLE patients presenting with multiple ischemic foci were significantly higher than those with normal MRI findings (x (2)=5.56, P<0.005; x (2)=14.59, P<0.005). Some cytokines are involved in the pathogenesis of CNS-NPSLE and correlated with cerebral MRI findings in CNS-NPSLE.

Keywords: Neuropsychiatric systemic lupus erythematous (NPSLE); central nervous system (CNS); cytokines; logistic regression analysis

References

  1. Iran J Radiol. 2011 Nov;8(3):157-60 - PubMed
  2. J Rheumatol. 2004 Nov;31(11):2156-62 - PubMed
  3. J Immunol. 2009 Jan 15;182(2):1192-201 - PubMed
  4. Arthritis Rheum. 2009 May;60(5):1463-71 - PubMed
  5. Autoimmun Rev. 2005 Jul;4(6):329-44 - PubMed
  6. Arthritis Rheum. 1999 Apr;42(4):599-608 - PubMed
  7. Mod Rheumatol. 2009;19(5):457-68 - PubMed
  8. Autoimmun Rev. 2008 Feb;7(4):297-304 - PubMed
  9. Semin Arthritis Rheum. 2011 Aug;41(1):1-11 - PubMed
  10. Br J Rheumatol. 1997 Feb;36(2):190-3 - PubMed
  11. Curr Pharm Des. 2005;11(8):963-72 - PubMed
  12. Arthritis Rheum. 1982 Nov;25(11):1271-7 - PubMed
  13. Arthritis Rheum. 2007 Apr;56(4):1242-50 - PubMed
  14. Curr Pharm Des. 2008;14(13):1261-9 - PubMed
  15. Curr Opin Rheumatol. 2004 Sep;16(5):527-33 - PubMed
  16. J Rheumatol. 2003 Mar;30(3):485-92 - PubMed

Publication Types