Display options
Cite
Kanazawa I. Osteocalcin as a hormone regulating glucose metabolism. World J Diabetes. 2015;6(18):1345-54doi: 10.4239/wjd.v6.i18.1345.
Kanazawa, I. (2015). Osteocalcin as a hormone regulating glucose metabolism. World journal of diabetes, 6(18), 1345-54. https://doi.org/10.4239/wjd.v6.i18.1345
Kanazawa, Ippei. "Osteocalcin as a hormone regulating glucose metabolism." World journal of diabetes vol. 6,18 (2015): 1345-54. doi: https://doi.org/10.4239/wjd.v6.i18.1345
Kanazawa I. Osteocalcin as a hormone regulating glucose metabolism. World J Diabetes. 2015 Dec 25;6(18):1345-54. doi: 10.4239/wjd.v6.i18.1345. PMID: 26722618; PMCID: PMC4689779.
Copy Download .nbib Format: NLM
Share it on

World J Diabetes. 2015 Dec 25;6(18):1345-54. doi: 10.4239/wjd.v6.i18.1345.

Osteocalcin as a hormone regulating glucose metabolism.

World journal of diabetes

Ippei Kanazawa

Affiliations

  1. Ippei Kanazawa, Department of Internal Medicine 1, Shimane University Faculty of Medicine, Shimane 693-8501, Japan.

PMID: 26722618 PMCID: PMC4689779 DOI: 10.4239/wjd.v6.i18.1345

Abstract

The number of patients with osteoporosis and diabetes is rapidly increasing all over the world. Bone is recently recognized as an endocrine organ. Accumulating evidence has shown that osteocalcin, which is specifically expressed in osteoblasts and secreted into the circulation, regulates glucose homeostasis by stimulating insulin expression in pancreas and adiponectin expression in adipocytes, resulting in improving glucose intolerance. On the other hand, insulin and adiponectin stimulate osteocalcin expression in osteoblasts, suggesting that positive feedforward loops exist among bone, pancreas, and adipose tissue. In addition, recent studies have shown that osteocalcin enhances insulin sensitivity and the differentiation in muscle, while secreted factors from muscle, myokines, regulate bone metabolism. These findings suggest that bone metabolism and glucose metabolism are associated with each other through the action of osteocalcin. In this review, I describe the role of osteocalcin in the interaction among bone, pancreas, brain, adipose tissue, and muscle.

Keywords: Adiponectin; Diabetes mellitus; Glucagon-like peptide-1; Glucose; Insulin; Osteocalcin; Undercarboxylated osteocalcin

References

  1. J Cell Biochem. 2006 Oct 15;99(3):824-34 - PubMed
  2. J Biol Chem. 1994 Dec 2;269(48):30659-67 - PubMed
  3. Bone. 2012 Feb;50(2):568-75 - PubMed
  4. J Bone Miner Res. 2015 Apr;30(4):596-605 - PubMed
  5. Diabetes Res Clin Pract. 2011 Jun;92 (3):393-9 - PubMed
  6. Cell Signal. 2015 Mar;27(3):532-44 - PubMed
  7. Cell. 2002 Nov 1;111(3):305-17 - PubMed
  8. Diabetes. 2002 Jun;51(6):1737-44 - PubMed
  9. Eur J Endocrinol. 2009 Feb;160(2):265-73 - PubMed
  10. J Bone Miner Res. 2006 Oct;21(10):1648-56 - PubMed
  11. BMC Cell Biol. 2007 Nov 29;8:51 - PubMed
  12. J Biol Chem. 2012 Mar 16;287(12 ):8757-68 - PubMed
  13. Cell. 2007 Aug 10;130(3):456-69 - PubMed
  14. J Bone Miner Res. 2009 May;24(5):785-91 - PubMed
  15. Clin Endocrinol (Oxf). 2001 Sep;55(3):341-7 - PubMed
  16. Horm Metab Res. 2014 May;46(5):341-7 - PubMed
  17. Am J Physiol Endocrinol Metab. 2000 Jan;278(1):E1-E14 - PubMed
  18. J Clin Invest. 2010 Jan;120(1):357-68 - PubMed
  19. Biochem Biophys Res Commun. 2012 Feb 3;418(1):134-9 - PubMed
  20. Bone. 2014 Dec;69:68-79 - PubMed
  21. Cell Metab. 2010 Feb 3;11(2):147-60 - PubMed
  22. J Biol Chem. 2011 May 27;286(21):19149-58 - PubMed
  23. Bone. 2011 Apr 1;48(4):720-5 - PubMed
  24. Cell. 2000 Jan 21;100(2):197-207 - PubMed
  25. Biochem Biophys Res Commun. 2015 Apr 10;459(3):437-42 - PubMed
  26. Bone. 2000 Mar;26(3):207-13 - PubMed
  27. J Clin Endocrinol Metab. 2009 Mar;94(3):827-32 - PubMed
  28. Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5266-70 - PubMed
  29. Nature. 2001 Jan 18;409(6818):307-12 - PubMed
  30. J Neurochem. 2005 Apr;93(2):383-91 - PubMed
  31. J Bone Miner Res. 1989 Dec;4(6):853-62 - PubMed
  32. Exp Cell Res. 2005 Sep 10;309(1):99-109 - PubMed
  33. J Endocrinol. 1992 Sep;134(3):485-92 - PubMed
  34. Gene. 2004 Jun 23;335:37-46 - PubMed
  35. Diabetes Metab Res Rev. 2009 Nov;25(8):768-72 - PubMed
  36. Gene. 1997 May 6;190(2):227-35 - PubMed
  37. J Clin Endocrinol Metab. 2009 Jan;94(1):237-45 - PubMed
  38. Diabetes Care. 2006 Jul;29(7):1573-8 - PubMed
  39. J Clin Invest. 2007 Oct;117(10):2860-8 - PubMed
  40. J Biol Chem. 2012 Apr 6;287(15):11616-28 - PubMed
  41. Clin Endocrinol (Oxf). 2005 Aug;63(2):131-8 - PubMed
  42. Biochim Biophys Acta. 1991 May 30;1078(1):31-4 - PubMed
  43. Genes Dev. 2010 Oct 15;24(20):2330-42 - PubMed
  44. J Biol Chem. 2005 Dec 2;280(48):40201-9 - PubMed
  45. Bone. 2004 Sep;35(3):792-8 - PubMed
  46. Osteoporos Int. 2011 Jan;22(1):187-94 - PubMed
  47. Cell. 2009 Sep 4;138(5):976-89 - PubMed
  48. Cell. 2010 Jul 23;142(2):296-308 - PubMed
  49. J Bone Miner Res. 2011 Jul;26(7):1680-3 - PubMed
  50. Nat Rev Genet. 2003 Aug;4(8):638-49 - PubMed
  51. Osteoporos Int. 2012 Feb;23 (2):761-70 - PubMed
  52. J Endocrinol Invest. 2000 May;23(5):295-303 - PubMed
  53. Endocrinology. 1985 Jan;116(1):296-302 - PubMed
  54. Cell. 2010 Jul 23;142(2):309-19 - PubMed
  55. J Biol Chem. 1994 Jan 14;269(2):1183-90 - PubMed
  56. J Bone Miner Res. 1993 May;8(5):567-73 - PubMed
  57. PLoS One. 2013;8(2):e57375 - PubMed
  58. J Cell Biol. 2008 Dec 29;183(7):1235-42 - PubMed
  59. Curr Diab Rep. 2009 Jun;9(3):208-14 - PubMed
  60. Nature. 1996 Aug 1;382(6590):448-52 - PubMed
  61. J Clin Endocrinol Metab. 2009 Jan;94(1):45-9 - PubMed

Publication Types