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Latchana N, Peck JR, Whitson BA, et al. Preservation solutions used during abdominal transplantation: Current status and outcomes. World J Transplant. 2015;5(4):154-64doi: 10.5500/wjt.v5.i4.154.
Latchana, N., Peck, J. R., Whitson, B. A., Henry, M. L., Elkhammas, E. A., & Black, S. M. (2015). Preservation solutions used during abdominal transplantation: Current status and outcomes. World journal of transplantation, 5(4), 154-64. https://doi.org/10.5500/wjt.v5.i4.154
Latchana, Nicholas, et al. "Preservation solutions used during abdominal transplantation: Current status and outcomes." World journal of transplantation vol. 5,4 (2015): 154-64. doi: https://doi.org/10.5500/wjt.v5.i4.154
Latchana N, Peck JR, Whitson BA, Henry ML, Elkhammas EA, Black SM. Preservation solutions used during abdominal transplantation: Current status and outcomes. World J Transplant. 2015 Dec 24;5(4):154-64. doi: 10.5500/wjt.v5.i4.154. PMID: 26722644; PMCID: PMC4689927.
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World J Transplant. 2015 Dec 24;5(4):154-64. doi: 10.5500/wjt.v5.i4.154.

Preservation solutions used during abdominal transplantation: Current status and outcomes.

World journal of transplantation

Nicholas Latchana, Joshua R Peck, Bryan A Whitson, Mitchell L Henry, Elmahdi A Elkhammas, Sylvester M Black

Affiliations

  1. Nicholas Latchana, Department of Surgery, the Ohio State University Wexner Medical, Columbus, OH 43210, United States.

PMID: 26722644 PMCID: PMC4689927 DOI: 10.5500/wjt.v5.i4.154

Abstract

Organ preservation remains an important contributing factor to graft and patient outcomes. During donor organ procurement and transportation, cellular injury is mitigated through the use of preservation solutions in conjunction with hypothermia. Various preservation solutions and protocols exist with widespread variability among transplant centers. In this review of abdominal organ preservation solutions, evolution of transplantation and graft preservation are discussed followed by classification of preservation solutions according to the composition of electrolytes, impermeants, buffers, antioxidants, and energy precursors. Lastly, pertinent clinical studies in the setting of hepatic, renal, pancreas, and intestinal transplantation are reviewed for patient and graft survival as well as financial considerations. In liver transplants there may be some benefit with the use of histidine-tryptophan-ketoglutarate (HTK) over University of Wisconsin solution in terms of biliary complications and potential cost savings. Renal grafts may experience increased initial graft dysfunction with the use of Euro-Collins thereby dissuading its use in support of HTK which can lead to substantial cost savings. University of Wisconsin solution and Celsior are favored in pancreas transplants given the concern for pancreatitis and graft thrombosis associated with HTK. No difference was observed with preservation solutions with respect to graft and patient survival in liver, renal, and pancreas transplants. Studies involving intestinal transplants are sparse but University of Wisconsin solution infused intraluminally in combination with an intra-vascular washout is a reasonable option until further evidence can be generated. Available literature can be used to ameliorate extensive variation across centers while potentially minimizing graft dysfunction and improving associated costs.

Keywords: Graft preservation; Intestine; Kidney; Liver; Pancreas

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