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Singh N, Gupta M, Kriplani A, et al. Role of Embryo Glue as a transfer medium in the outcome of fresh non-donor in-vitro fertilization cycles. J Hum Reprod Sci. 2015;8(4):214-7doi: 10.4103/0974-1208.170398.
Singh, N., Gupta, M., Kriplani, A., & Vanamail, P. (2015). Role of Embryo Glue as a transfer medium in the outcome of fresh non-donor in-vitro fertilization cycles. Journal of human reproductive sciences, 8(4), 214-7. https://doi.org/10.4103/0974-1208.170398
Singh, Neeta, et al. "Role of Embryo Glue as a transfer medium in the outcome of fresh non-donor in-vitro fertilization cycles." Journal of human reproductive sciences vol. 8,4 (2015): 214-7. doi: https://doi.org/10.4103/0974-1208.170398
Singh N, Gupta M, Kriplani A, Vanamail P. Role of Embryo Glue as a transfer medium in the outcome of fresh non-donor in-vitro fertilization cycles. J Hum Reprod Sci. 2015 Oct-Dec;8(4):214-7. doi: 10.4103/0974-1208.170398. PMID: 26752856; PMCID: PMC4691973.
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J Hum Reprod Sci. 2015 Oct-Dec;8(4):214-7. doi: 10.4103/0974-1208.170398.

Role of Embryo Glue as a transfer medium in the outcome of fresh non-donor in-vitro fertilization cycles.

Journal of human reproductive sciences

Neeta Singh, Monica Gupta, Alka Kriplani, Perumal Vanamail

Affiliations

  1. Department of Obstetrics and Gynaecology, AIIMS, New Delhi, India.

PMID: 26752856 PMCID: PMC4691973 DOI: 10.4103/0974-1208.170398

Abstract

BACKGROUND: EmbryoGlue is a hyaluronan-enriched embryo transfer (ET) medium which aids in implantation of embryos, hence, improves pregnancy rates in in-vitro fertilization-ET cycles (IVF-ET).

AIM: To evaluate the role of EmbryoGlue in improving implantation and pregnancy rates.

DESIGN AND SETTING: A prospective case-control study conducted at assisted reproductive center of a tertiary care hospital.

METHOD: In 42 women undergoing IVF, embryos were transferred into 50 μL of EmbryoGlue for 10 min prior to transfer inside uterine cavity. In the control group (n = 42), embryos were transferred to conventional blastocyst culture medium. Statistical analysis was performed using SPSS IBM version 19.0.

RESULTS: Clinical pregnancy rate in the study group was 7% higher than the control group. The difference, however, was not statistically significant. In addition, no improvement in implantation rates was observed in the study group. However, significant difference (P = 0.04) in clinical pregnancy rate was observed with the EmbryoGlue in patients with previous IVF failure. In the study group, 50% patients (6/12) with previous IVF failure had successful implantation, but in the control group none of the patients (0/11) with previous implantation failure could achieve pregnancy.

CONCLUSION: It is difficult to conclude a favourable role of EmbryoGlue in IVF-ET cycles with a good prognosis. However, in patients with recurrent implantation failure, it may be considered as a useful transfer medium.

Keywords: Embryo transfer; hyaluronan; implantation; in-vitro fertilization; pregnancy; recurrent implantation failure

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