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Mizar P, Niebuhr R, Hutchings M, et al. Thioamination of Alkenes with Hypervalent Iodine Reagents. Chemistry. 2016;22(5):1614-7doi: 10.1002/chem.201504636.
Mizar, P., Niebuhr, R., Hutchings, M., Farooq, U., & Wirth, T. (2016). Thioamination of Alkenes with Hypervalent Iodine Reagents. Chemistry (Weinheim an der Bergstrasse, Germany), 22(5), 1614-7. https://doi.org/10.1002/chem.201504636
Mizar, Pushpak, et al. "Thioamination of Alkenes with Hypervalent Iodine Reagents." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 22,5 (2016): 1614-7. doi: https://doi.org/10.1002/chem.201504636
Mizar P, Niebuhr R, Hutchings M, Farooq U, Wirth T. Thioamination of Alkenes with Hypervalent Iodine Reagents. Chemistry. 2016 Jan 26;22(5):1614-7. doi: 10.1002/chem.201504636. Epub 2016 Jan 07. PMID: 26660291; PMCID: PMC4725223.
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Chemistry. 2016 Jan 26;22(5):1614-7. doi: 10.1002/chem.201504636. Epub 2016 Jan 07.

Thioamination of Alkenes with Hypervalent Iodine Reagents.

Chemistry (Weinheim an der Bergstrasse, Germany)

Pushpak Mizar, Rebecca Niebuhr, Matthew Hutchings, Umar Farooq, Thomas Wirth

Affiliations

  1. School of Chemistry, Cardiff University, Park Place, Main Building, Cardiff, CF10 3AT, UK), Fax.
  2. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad, Pakistan.
  3. School of Chemistry, Cardiff University, Park Place, Main Building, Cardiff, CF10 3AT, UK), Fax. [email protected].

PMID: 26660291 PMCID: PMC4725223 DOI: 10.1002/chem.201504636

Abstract

An efficient thioamination of alkenes mediated by iodine(III) reagents is described. The use of different sulfur nucleophiles allows the flexible synthesis of 1,2-aminothiols from alkenes. By employing chiral iodine(III) reagents, a stereoselective version of the thioamination protocol has also been developed.

© 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

Keywords: addition; alkenes; amination; heterocycles; iodine

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