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Allen PS, Brown AW, Brown MM, et al. Taurine and vitamin E supplementations have minimal effects on body composition, hepatic lipids, and blood hormone and metabolite concentrations in healthy Sprague Dawley rats. Nutr Diet Suppl. 2015;7:77-85doi: 10.2147/NDS.S88888.
Allen, P. S., Brown, A. W., Brown, M. M., Hsu, W. H., & Beitz, D. C. (2015). Taurine and vitamin E supplementations have minimal effects on body composition, hepatic lipids, and blood hormone and metabolite concentrations in healthy Sprague Dawley rats. Nutrition and dietary supplements, 777-85. https://doi.org/10.2147/NDS.S88888
Allen, Portia S, et al. "Taurine and vitamin E supplementations have minimal effects on body composition, hepatic lipids, and blood hormone and metabolite concentrations in healthy Sprague Dawley rats." Nutrition and dietary supplements vol. 7 (2015): 77-85. doi: https://doi.org/10.2147/NDS.S88888
Allen PS, Brown AW, Brown MM, Hsu WH, Beitz DC. Taurine and vitamin E supplementations have minimal effects on body composition, hepatic lipids, and blood hormone and metabolite concentrations in healthy Sprague Dawley rats. Nutr Diet Suppl. 2015;7:77-85. doi: 10.2147/NDS.S88888. Epub 2015 Oct 20. PMID: 26752960; PMCID: PMC4706234.
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Nutr Diet Suppl. 2015;7:77-85. doi: 10.2147/NDS.S88888. Epub 2015 Oct 20.

Taurine and vitamin E supplementations have minimal effects on body composition, hepatic lipids, and blood hormone and metabolite concentrations in healthy Sprague Dawley rats.

Nutrition and dietary supplements

Portia S Allen, Andrew W Brown, Michelle M Bohan Brown, Walter H Hsu, Donald C Beitz

Affiliations

  1. Department of Animal Science, Iowa State University, Ames, Iowa, United States of America.
  2. Nutrition Obesity Research Center and Office of Energetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
  3. Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa, United States of America.
  4. Department of Biomedical Sciences, Iowa State University, Ames, Iowa, United States of America.

PMID: 26752960 PMCID: PMC4706234 DOI: 10.2147/NDS.S88888

Abstract

BACKGROUND: As prescriptions for off-label pharmaceutical use and autonomous administration of over-the-counter nutraceuticals become mainstream, thorough assessments of these compounds are warranted.

OBJECTIVE: To determine the effects of gemfibrozil, rosiglitazone, metformin, taurine, and vitamin E on body composition, hepatic lipids, and metabolic hormone and blood metabolite concentrations in a healthy, outbred rat cohort.

METHODS: Male Sprague Dawley rats were fed a purified 10 kcal% from fat diet for 56 days and assigned to diet alone (control) or diet plus oral administration of gemfibrozil (34 mg/kg), metformin (500 mg/kg), rosiglitazone (3 mg/kg), taurine (520 mg/kg), or vitamin E (200 mg/kg).

RESULTS: Rosiglitazone administration resulted in a 56% increase in carcass adiposity, cautioning potential prescriptive off-label use. Taurine supplementation had no adverse effects on evaluated parameters. A modest but significant increase in liver triacylglycerol content was observed with vitamin E supplementation compared with control (Δ 17.2 g triacylglycerol/100 g liver lipid).

CONCLUSIONS: The evaluated pharmaceuticals had effects in a healthy population similar to the reported effects in their target population and the nutraceuticals had minimal effects on the measured physiological parameters.

Keywords: animal model; gemfibrozil; metformin; thiazolidinedione

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