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Hatzoglou V, Karimi S, Diamond EL, et al. Nonenhancing Leptomeningeal Metastases: Imaging Characteristics and Potential Causative Factors. Neurohospitalist. 2016;6(1):24-8doi: 10.1177/1941874415591702.
Hatzoglou, V., Karimi, S., Diamond, E. L., Lis, E., Krol, G., Holodny, A. I., & Young, R. J. (2016). Nonenhancing Leptomeningeal Metastases: Imaging Characteristics and Potential Causative Factors. The Neurohospitalist, 6(1), 24-8. https://doi.org/10.1177/1941874415591702
Hatzoglou, Vaios, et al. "Nonenhancing Leptomeningeal Metastases: Imaging Characteristics and Potential Causative Factors." The Neurohospitalist vol. 6,1 (2016): 24-8. doi: https://doi.org/10.1177/1941874415591702
Hatzoglou V, Karimi S, Diamond EL, Lis E, Krol G, Holodny AI, Young RJ. Nonenhancing Leptomeningeal Metastases: Imaging Characteristics and Potential Causative Factors. Neurohospitalist. 2016 Jan;6(1):24-8. doi: 10.1177/1941874415591702. PMID: 26753054; PMCID: PMC4680901.
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Neurohospitalist. 2016 Jan;6(1):24-8. doi: 10.1177/1941874415591702.

Nonenhancing Leptomeningeal Metastases: Imaging Characteristics and Potential Causative Factors.

The Neurohospitalist

Vaios Hatzoglou, Sasan Karimi, Eli L Diamond, Eric Lis, George Krol, Andrei I Holodny, Robert J Young

Affiliations

  1. Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
  2. Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

PMID: 26753054 PMCID: PMC4680901 DOI: 10.1177/1941874415591702

Abstract

The diagnosis of leptomeningeal metastasis (LM) has increased in frequency, as new therapies have lengthened the survival of patients with cancer. Early diagnosis and intervention help improve quality of life and prevent further neurological deterioration in LM. The detection of LM is often established by magnetic resonance imaging examinations, cerebrospinal fluid analysis, or both. We present a series of cases where LM was identified on fluid-attenuated inversion recovery or T2-weighted image but was nonenhancing on the traditionally more sensitive postcontrast T1-weighted sequences. Nonenhancing LM is unusual and not yet fully understood but should be considered in the appropriate clinical context and may become more common with increased utilization of antiangiogenic therapies.

Keywords: brain neoplasms; imaging; meningeal neoplasms; nervous system neoplasms; techniques

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