Display options
Cite
Indu TH, Basutkar RS. Hypersensitivity reaction associated with phenytoin. J Basic Clin Pharm. 2015;6(4):119-21doi: 10.4103/0976-0105.168054.
Indu, T. H., & Basutkar, R. S. (2015). Hypersensitivity reaction associated with phenytoin. Journal of basic and clinical pharmacy, 6(4), 119-21. https://doi.org/10.4103/0976-0105.168054
Indu, T H, and Basutkar, Roopa Satyanarayan. "Hypersensitivity reaction associated with phenytoin." Journal of basic and clinical pharmacy vol. 6,4 (2015): 119-21. doi: https://doi.org/10.4103/0976-0105.168054
Indu TH, Basutkar RS. Hypersensitivity reaction associated with phenytoin. J Basic Clin Pharm. 2015 Sep;6(4):119-21. doi: 10.4103/0976-0105.168054. PMID: 26692739; PMCID: PMC4660484.
Copy Download .nbib Format: NLM
Share it on

J Basic Clin Pharm. 2015 Sep;6(4):119-21. doi: 10.4103/0976-0105.168054.

Hypersensitivity reaction associated with phenytoin.

Journal of basic and clinical pharmacy

T H Indu, Roopa Satyanarayan Basutkar

Affiliations

  1. Department of Pharmacy Practice, JSS College of Pharmacy (Affiliated to JSS University, Mysore, Karnataka, India), Ootacamund, Ooty, Tamil Nadu, India.

PMID: 26692739 PMCID: PMC4660484 DOI: 10.4103/0976-0105.168054

Abstract

Hypersensitivity reactions with antiepileptic drugs (AEDs) are generally associated with aromatic AEDs. We present a case of hypersensitivity reactions followed by administration of phenytoin with diazepam and ranitidine in a patient with generalized tonic-clonic seizures. Antigen-antibody reactions or decreased levels of epoxide hydrolase are well known with phenytoin. Increased level of serum phenytoin causing toxicities due to competitive inhibition with diazepam on co-administration was also reported in the literature. Prevention of the adverse effects with AEDs is a multi-stage process, which requires implementation of preventive measures through careful monitoring and prompts interventions.

Keywords: Antiepileptics; hypersensitivity reaction; phenytoin

References

  1. Arch Dermatol. 1978 Sep;114(9):1350-3 - PubMed
  2. Drug Intell Clin Pharm. 1988 Dec;22(12):979-80 - PubMed
  3. Br Med J (Clin Res Ed). 1981 May 9;282(6275):1512 - PubMed
  4. Drug Saf. 1999 Dec;21(6):489-501 - PubMed
  5. Epilepsy Res. 2004 Apr-May;59(2-3):155-65 - PubMed
  6. Clin Pharm. 1987 Sep;6(9):728-34 - PubMed
  7. Ann Pharmacother. 2003 May;37(5):659-63 - PubMed
  8. Ann Intern Med. 1981 Aug;95(2):244-5 - PubMed
  9. Br J Clin Pharmacol. 1979 Jul;8(1):33-6 - PubMed
  10. Ann Pharmacother. 1993 Dec;27(12):1448-51 - PubMed

Publication Types