Display options
Share it on

Case Rep Pulmonol. 2015;2015:370462. doi: 10.1155/2015/370462. Epub 2015 Nov 26.

Untreated Active Tuberculosis in Pregnancy with Intraocular Dissemination: A Case Report and Review of the Literature.

Case reports in pulmonology

Shadi Rezai, Stephen LoBue, Daniel Adams, Yewande Oladipo, Ramses Posso, Tiffany Mapp, Crystal Santiago, Manisha Jain, William D Marino, Cassandra E Henderson

Affiliations

  1. Department of Obstetrics and Gynecology, Lincoln Medical and Mental Health Center, Bronx, NY 10451, USA.
  2. St. George's University, School of Medicine, Grenada.
  3. Coney Island Hospital, Pulmonary Medicine, Brooklyn, NY 11235, USA.
  4. Department of Obstetrics and Gynecology, Lincoln Medical and Mental Health Center, Bronx, NY 10451, USA ; Cornell Medical College, NY 10065, USA.

PMID: 26693374 PMCID: PMC4674577 DOI: 10.1155/2015/370462

Abstract

Background. Tuberculosis (TB) is a disease that affects hundreds of millions of people across the world. However, the incidence in developed countries has decreased over the past decades causing physicians to become unfamiliar with its unspecific symptoms. Pregnant individuals are especially difficult because many symptoms of active TB can mimic normal physiological changes of pregnancy. We present a case report of a 26-year-old multiparous woman, G4P3003, at 38-week gestation with a history of positive PPD who emigrated from Ghana 6 years ago. She came to the hospital with an initial complaint of suprapubic pain, pressure, and possible leakage of amniotic fluid for the past week. Patient also complained of a productive cough for the past 3 to 4 months with a decrease in vision occurring with the start of pregnancy. Visual acuity was worse than 20/200 in both eyes. Definitive diagnosis of active TB was delayed due to patient refusal of chest X-ray. Fortunately, delay in diagnosis was minimized since patient delivered within 24 hours of admission. Active TB was confirmed with intraocular dissemination. Patient had optic atrophy OS (left eye) and papillitis, choroiditis, and uveitis OD (right eye) due to TB infiltration. Fetus was asymptomatic and anti-TB therapy was started for both patients.

References

  1. Ann Otol Rhinol Laryngol. 2004 Aug;113(8):648-51 - PubMed
  2. J Immunol. 1997 Jun 15;158(12):5589-95 - PubMed
  3. Clin Obstet Gynecol. 2010 Jun;53(2):311-21 - PubMed
  4. N Engl J Med. 1999 Aug 26;341(9):645-9 - PubMed
  5. Arch Ophthalmol. 1986 Mar;104(3):444-6 - PubMed
  6. Emerg Infect Dis. 2013 Mar;19(3):514-6 - PubMed
  7. BMC Infect Dis. 2014 Nov 19;14:617 - PubMed
  8. Clin Endocrinol (Oxf). 1990 Aug;33(2):279-89 - PubMed
  9. Int J Tuberc Lung Dis. 2004 Jan;8(1):59-69 - PubMed
  10. J Immunol. 1998 Mar 1;160(5):2231-7 - PubMed
  11. Clin Infect Dis. 2007 Jul 15;45(2):241-9 - PubMed
  12. J Immunol. 1996 Apr 1;156(7):2406-12 - PubMed
  13. Int J Gynaecol Obstet. 1994 Feb;44(2):119-24 - PubMed
  14. PLoS One. 2013 Sep 30;8(9):e76552 - PubMed
  15. J Clin Microbiol. 2011 Apr;49(4):1202-5 - PubMed
  16. Ophthalmic Epidemiol. 2002 Oct;9(4):239-49 - PubMed
  17. Clin Infect Dis. 2012 Dec;55(11):1532-49 - PubMed
  18. Curr Opin Immunol. 1999 Jun;11(3):346-51 - PubMed
  19. Lancet Infect Dis. 2005 Jul;5(7):415-30 - PubMed
  20. Int Ophthalmol. 1996-1997;20(4):223-8 - PubMed
  21. J Clin Microbiol. 2013 Feb;51(2):644-6 - PubMed
  22. Medicine (Baltimore). 1997 Jan;76(1):53-61 - PubMed
  23. Am J Respir Crit Care Med. 2012 Apr 1;185(7):779-84 - PubMed
  24. Int J Gynaecol Obstet. 2003 Mar;80(3):247-53 - PubMed
  25. Immunology. 2001 May;103(1):1-9 - PubMed
  26. MMWR Morb Mortal Wkly Rep. 2010 Mar 19;59(10):289-94 - PubMed
  27. Int J Infect Dis. 2015 Mar;32:124-7 - PubMed
  28. Surv Ophthalmol. 2007 Nov-Dec;52(6):561-87 - PubMed
  29. J Emerg Med. 2013 Aug;45(2):e27-30 - PubMed
  30. Proc Assoc Am Physicians. 1996 Sep;108(5):374-81 - PubMed
  31. Int J Tuberc Lung Dis. 2004 Dec;8(12):1443-7 - PubMed
  32. Int Ophthalmol. 1995-1996;19(5):293-8 - PubMed
  33. Ocul Immunol Inflamm. 2003 Dec;11(4):277-86 - PubMed
  34. Pan Afr Med J. 2012;12:65 - PubMed
  35. Neth J Med. 1998 Mar;52(3):100-6 - PubMed
  36. BJOG. 2010 Apr;117(5):585-90 - PubMed
  37. J Clin Endocrinol Metab. 2011 May;96(5):1533-40 - PubMed
  38. BMJ Case Rep. 2012 Sep 12;2012:null - PubMed

Publication Types