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Zerehpoosh FB, Sabeti S, Sharifi G, et al. Demographic study of pituitary adenomas undergone trans-sphenoidal surgery in Loghman Hakim Hospital, Tehran, Iran 2001-2013. Indian J Endocrinol Metab. 2015;19(6):791-6doi: 10.4103/2230-8210.167551.
Zerehpoosh, F. B., Sabeti, S., Sharifi, G., Shakeri, H., Alipour, S., & Arman, F. (2015). Demographic study of pituitary adenomas undergone trans-sphenoidal surgery in Loghman Hakim Hospital, Tehran, Iran 2001-2013. Indian journal of endocrinology and metabolism, 19(6), 791-6. https://doi.org/10.4103/2230-8210.167551
Zerehpoosh, Farahnaz Bidari, et al. "Demographic study of pituitary adenomas undergone trans-sphenoidal surgery in Loghman Hakim Hospital, Tehran, Iran 2001-2013." Indian journal of endocrinology and metabolism vol. 19,6 (2015): 791-6. doi: https://doi.org/10.4103/2230-8210.167551
Zerehpoosh FB, Sabeti S, Sharifi G, Shakeri H, Alipour S, Arman F. Demographic study of pituitary adenomas undergone trans-sphenoidal surgery in Loghman Hakim Hospital, Tehran, Iran 2001-2013. Indian J Endocrinol Metab. 2015 Nov-Dec;19(6):791-6. doi: 10.4103/2230-8210.167551. PMID: 26693430; PMCID: PMC4673808.
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Indian J Endocrinol Metab. 2015 Nov-Dec;19(6):791-6. doi: 10.4103/2230-8210.167551.

Demographic study of pituitary adenomas undergone trans-sphenoidal surgery in Loghman Hakim Hospital, Tehran, Iran 2001-2013.

Indian journal of endocrinology and metabolism

Farahnaz Bidari Zerehpoosh, Shahram Sabeti, Guive Sharifi, Hania Shakeri, Setareh Alipour, Farid Arman

Affiliations

  1. Department of Pathology, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  2. Department of Neurosurgery, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

PMID: 26693430 PMCID: PMC4673808 DOI: 10.4103/2230-8210.167551

Abstract

BACKGROUND: Pituitary adenomas (PAs) are abnormal benign tumors that develop in the pituitary gland. This study aimed to assess the prevalence of different types of PAs with an indication for trans-sphenoidal surgery in a well-defined population referred to Loghman Hakim Hospital during 2001-2013.

SUBJECTS AND METHODS: In this retrospective study, the prevalence rate and symptoms associated with pituitary mass and hormone excess in operated patients were investigated. The diagnosis was verified after retrieval of clinical, hormonal, radiological, and pathological data. Demographic data were collected in all cases. Descriptive analysis, t-test, one-way analysis of variance and Fischer exacts test were used.

RESULTS: A total of 278 patients with PAs who underwent surgical interventions were evaluated. Most of the patients were aged 40-50 years with an average of 41 ± 14. The most prominent complaint was pressure effect, which was detected in 153 cases (55.2%). At the second place, hormonal disorders were observed in 125 cases (44.8%). Type of pituitary tumors were: Prolactinomas (29.1%), growth hormone (GH)-producing tumors (25%), nonfunctioning PAs (28.4%), adrenocorticotropic hormone (ACTH)-producing tumors (2.1%), thyroid stimulating hormone (TSH)-producing tumors (0.7%), GH/prolactin (13.6%), GH/ACTH (0.3%), and TSH/ACTH (0.3%). Fifty-seven patients presented with recurrent adenomas. Pituitary apoplexy was found in 11 patients. One case of Sheehan syndrome was recorded among these. The correlations between clinical symptoms and patients, age and sex were not significant.

CONCLUSION: The overview of demographic characteristics in Iranian patients with PAs with surgical indication has been discussed in the present investigation. The prevalence of different types of PAs and the most common clinical symptoms have been demonstrated.

Keywords: Clinical symptoms; pituitary adenomas; prevalence

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